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87篇 您的检索式:作者名="Theoleyre"
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1Downregulation of the Spi-1/PU.1 oncogene induces the expression of TRIM10/HERF1, a key factor required for terminal erythroid cell differentiation and survival显示文摘Spi-1/PU.1 和 Fli-1 oncoproteins 的持续表示在老鼠 erythroleukemia 房间堵住 globin 基因激活;然而,仅仅 Spi-1/PU.1 表示禁止 exon 的包括 16 在成熟 4.1R mRNA。这个拼接的事件为红血房间膜正直为功能的 4.1R 蛋白质并且,因此是关键的。这份报告证明 Spi-1/PU.1 downregulation 导致 TRIM10/hematopoietic 戒指手指 1 的激活(HERF1 ) ,分成三部分的主题(修剪) 的一个成员为 globin 基因抄写需要的 /RBCC 蛋白质家庭。另外,我们证明 TRIM10/HERF1 为 exon 拼接调整被要求 16 在迟了的 erythroid 区别期间。用可诱导的 overexpression 和 silencing 途径,我们发现了那:(1 ) TRIM10/HERF1 击倒在导致的 dimethylsulfoxide (DMSO ) 禁止拼接的血红素生产和 exon 和扳机房间 apoptosis 房间;(2 ) TRIM10/HERF1 upregulation 被要求,但是在它的自己上是不够的激活 exon 保留;(3 ) Fli-1 没在 TRIM10/HERF1 表示上有效果,而也导致 DMSO 的 downregulation 或 Spi-1/PU.1 shRNA 击倒表示是足够的激活 TRIM10/HERF1 表示;并且(4 ) Spi-1/PU.1 击倒的扳机抄写和拼接的事件独立于化学正式就职。总的来说,这些数据显示主要 Spi-1/PU.1 downregulation 通过至少二条小径,其一条要求 TRIM10/HERF1 upregulation 和平行对迟了的 erythroid 区别起作用 Spi-1/PU.1-induced Fli-1 用以遮闭之物规章的串联。Rand Blaybel Orianne Theoleyre Alexandre Douablin Faouzi Baklouti 2008Cell Research2008,18,8:3
2Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities显示文摘Y Wittrant S Theoleyre S Couillaud C Dunstan D Heymann F Rédini 2003Experimental Cell Research2003,,2:2
3IL-6, RANKL, TNF- alpha/IL-1: inte-rrelations in hone resorption pathophysiology 显示文摘Kwan TS Padrines M Theoleyre S 2004Cytokine Growth Factor Rev2004,15,1:1
4IL-6,RANKL,TNF -alpha/ IL-1:interrelations in bone resorption pathophysiology显示文摘Kwan TS Padrines M Theoleyre S 0,,01:1
5The molecular triad OPG/RANK/RANKL:involvement in the orchestration of pathophysiological bone remodeling显示文摘Theoleyre S Wittrant Y Tat SK 0,,06:1
6The molecular triad OPG/RANK/RANKL: involvement in the or- chestration of pathophysiological bone remodeling 显示文摘Theoleyre S Wittrant Y Tat S K 2004Cytokine Growth Factor Rev2004,15,6:1
7Cellular activity and signaling induced by ostoprotegerin in os- teoclasts:involvement of receptor activator of nuclear factor κB ligand and MAPK 显示文摘Theoleyre S Wittrant Y Couillaud S 2004Biochimica et Bio- physica Acta2004,1644,1:1
8Osteoprotegerin differentially regulates protease expression in osteoclast cultures 显示文摘Wittrant Y Couillaud S Theoleyre S 2002Biochem Biophys Res Commun2002,293,1:1
9Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-κB ligand and osteoprotegerin biological activities显示文摘Wittrant Y Theoleyre S Couillaud S 2004Exp Cell Res2004,293,4:1
10The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling显示文摘THEOLEYRE S WITTRANT Y TAT S K 2004Cytokine Growth Fact or Rev2004,15,:1
11IL-6, RANKL, TNF-alpha/IL- 1: interrelations in bone resorption pathophysiology显示文摘Kwan Tat S Padrines M Theoleyre S 2004Cytokine Growth Factor Rev2004,15,:1
12IL-6 , RANKL, TNF- alpha/IL-1 : interrelations in bone resorption pathophysiology 显示文摘Kwan TS Padrines M Theoleyre S 2004Cytokine Growth Facter Rev2004,15,1:1
13Regulation of osteoclast protease expression by RANKL显示文摘Y Wittrant S Theoleyre S Couillaud C Dunstan D Heymann F Rédini 2003Biochemical and Biophysical Research Communications2003,,3:1
14A Self-Organization Structure for Hybrid Networks显示文摘Theoleyre F Valois F 2008Ad Hoc Networks2008,6,3:1
15The molecular triad OPG/RANK/ RANKL:involvement in the orchestration of pathophysiological bone re- modeling 显示文摘Theoleyre S Wittrant Y Tat SK 2004Cytokine Growth Factor Rev2004,15,7:1
16The molecular triad OPG/RANK/RANKL:involvement in the orchestration of pathophysiological bone remodeling显示文摘Theoleyre S Wittrant Y Tat SK 2004Cytokine Growth Factor Rev2004,15,6:1
17Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF- κ B ligand and osteoprotegerin biological activities 显示文摘Theoleyre S Couillaud C Dunstan D 2004Experimental Cell Research2004,293,2:1
1811-6, rankl, Tnf-alpha/il-1: Interrelations in bone resorption pathophysiology 显示文摘Kwan tat S Padfines M Theoleyre S 2004Cytokine Growth Factor Rev2004,15,1:1
19IL-6,RANKL,TNF-alpha/IL-1:interrelations in bone resorption pathophysiology显示文摘Kwan Tat S Padrines M Theoleyre S 2004Cytokine Growth Factor Rev2004,15,1:1
20RANKL/RANK/ OPG:new therapeutic targets in bone tumours and associated osteolysis显示文摘Wittrant Y Theoleyre S Chipoy C 2004Biochimicaet Biophysica Acta2004,1704,2:1
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