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| 1 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 2 | Mid-infrared dual-comb spectroscopy with electro-optic modulators显示文摘Absorption spectroscopy of fundamental ro-vibrational transitions in the mid-infrared region provides a powerful tool for studying the structure and dynamics of molecules in the gas phase and for sensitive and quantitative gas sensing.Laser frequency combs permit novel approaches to perform broadband molecular spectroscopy.Multiplex dual-comb spectroscopy without moving parts can achieve particularly high speed,sensitivity and resolution.However,achieving Doppler-limited resolution in the mid-infrared still requires overcoming instrumental challenges.Here we demonstrate a new approach based on difference-frequency generation of frequency-agile near-infrared frequency combs that are produced using electro-optic modulators.The combs have a remarkably flat intensity distribution,and their positions and line spacings can be freely selected by simply dialing a knob.Using the proposed technique,we record,in the 3-μm region,Doppler-limited absorption spectra with resolved comb lines within milliseconds,and precise molecular line parameters are retrieved.Our technique holds promise for fast and sensitive time-resolved studies of,for example,trace gases. | Ming Yan Pei-Ling Luo Kana Iwakuni Guy Millot Theodor W Hänsch Nathalie Picqué | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 3 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 4 | Development of a laser capture microscope-based single-cell-type proteomics tool for studying proteomes of individual cell layers of plant roots显示文摘Single-cell-type proteomics provides the capability to revealing the genomic and proteomics information at cell-level resolution.However,the methodology for this type of research has not been well-developed.This paper reports developing a workflow of laser capture microdissection(LCM)followed by gel-liquid chromatography-tandem mass spectrometry(GeLC-MS/MS)-based proteomics analysis for the identification of proteomes contained in individual cell layers of tomato roots.Thin-sections(~10-μm thick,10 sections per root tip)were prepared for root tips of tomato germinating seedlings.Epidermal and cortical cells(5000–7000 cells per tissue type)were isolated under a LCM microscope.Proteins were isolated and then separated by SDS–polyacrylamide gel electrophoresis followed by in-gel-tryptic digestion.The MS and MS/MS spectra generated using nanoLC-MS/MS analysis of the tryptic peptides were searched against ITAG2.4 tomato protein database to identify proteins contained in each single-cell-type sample.Based on the biological functions,proteins with proven functions in root hair development were identified in epidermal cells but not in the cortical cells.Several of these proteins were found in Al-treated roots only.The results demonstrated that the cell-type-specific proteome is relevant for tissue-specific functions in tomato roots.Increasing the coverage of proteomes and reducing the inevitable cross-contamination from adjacent cell layers,in both vertical and cross directions when cells are isolated from slides prepared using intact root tips,are the major challenges using the technology in proteomics analysis of plant roots. | Yingde Zhu Hui Li Sarabjit Bhatti Suping Zhou Yong Yang Tara Fish Theodore W Thannhauser | 2016 | Horticulture Research2016，3，1： | 2 |
| 5 | Inflammation-related gene expression profiles of salivary extracellular vesicles in patients with head trauma显示文摘At present,there is no reliable biomarker for the diagnosis of traumatic brain injury(TBI).Studies have shown that extracellular vesicles released by damaged cells into biological fluids can be used as potential biomarkers for diagnosis of TBI and evaluation of TBI severity.We hypothesize that the genetic profile of salivary extracellular vesicles in patients with head trauma differs from that in uninjured subjects.Findings from this hypothesis would help investigate the severity of TBI.This study included 19 subjects,consisting of seven healthy controls who denied history of head trauma,six patients diagnosed with concussion injury from an outpatient concussion clinic,and six patients with TBI who received treatment in the emergency department within 24 hours after injury.Real-time PCR analysis of salivary extracellular vesicles in participants was performed using TaqMan Human Inflammation array.Gene expression analysis revealed nine upregulated genes in emergency department patients(LOX5,ANXA3,CASP1,IL2RG,ITGAM,ITGB2,LTA4H,MAPK14,and TNFRSF1A)and 13 upregulated genes in concussion clinic patients compared with healthy participants(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,LTB4R2,LTB4R,PTAFR,CYSLTR1,CES1,KLK1,MC2R,and PTGER3).Each patient group had a unique profile.Comparison between groups showed that 15 inflammation-related genes had significant expression change.Our results indicate that inflammation biomarkers can be used for diagnosis of TBI and evaluation of disease severity.This study was approved by the Institutional Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16). | Yan Cheng Mandy Pereira Neha P.Raukar John L.Reagan Mathew Quesenberry Laura Goldberg Theodor Borgovan W Curt LaFrance Jr Mark Dooner Maria Deregibus Giovanni Camussi Bharat Ramratnam Peter Quesenberry | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 6 | Metabolic adaptations of plant respiration to nutritional phosphate deprivation 显示文摘 | Theodorou M E Plaxton W C | 1993 | Plant Physiol1993，101，： | 1 |
| 7 | Detailed molecular structure of a vinyl polymer glass 显示文摘 | THEODOROU D N SUTER U W | 1985 | Macromolecules1985，18，7： | 1 |
| 8 | Level-of-service model for pedestrians at signalized intersections显示文摘 | Theodore A Petritsch Bruce W Landis Peyton S McLeod | 2005 | Journal of Transportation Research Board2005，，1： | 1 |
| 9 | Investment in Human Capital显示文摘 | Theodore Sehultz W | 1961 | The American Economist1961，，： | 1 |
| 10 | The Value of the Ability to Deal with Disequilibria显示文摘 | Schultz Theodore W | 1975 | Journal of Economic Literature1975，13，3： | 1 |
| 11 | The High Value of Human Time: Population Equilibrium 显示文摘 | Schultz Theodore W | 1974 | Journal of Political Economy1974，，2： | 1 |
| 12 | H(A)ansch,and Immanuel Bloch,Collapse and revival of the matter wave field of a Bose-Einstein condensate显示文摘 | Markus Greiner Olaf Mandel Theodor W | 2002 | Nature(London)2002，419，： | 1 |
| 13 | Carbon/Carbon Composite Bipolar Plate for PEM Fuel Cells显示文摘 | Theodore M Besmann James W Klett John J Henry | 2000 | Journal of the Electrochemical Society2000，，11： | 1 |
| 14 | Genetic algorithms for autonomous robot navigation显示文摘 | Theodore W M Kaveh A Roger L W | 2007 | IEEE Instrumentation and Mea- surement Magazine2007，12，1： | 1 |
| 15 | Institutions and the Rising Economic Value of Man 显示文摘 | Theodore W Schuhz | 1968 | American Journal of Agricultural Economics1968，，18： | 1 |
| 16 | HIF-1 reduces ischaemi- a-reperfusion injury in the heart by targeting the mitochondrial per- meability transition pore 显示文摘 | Ong S G Lee W H Theodorou L | 2014 | Cardiovasc Res2014，104，1： | 1 |
| 17 | Institutions and the rising economic value of man显示文摘 | | 1968 | American Journal of Agricultural Economics1968，，6： | 1 |
| 18 | Protein metabolism in rat gastrocnemius muscle after stimulated chronic concentric exercise显示文摘 | Theodore S W Booth F W | 1990 | J Appl Physiol1990，，： | 1 |
| 19 | Opportunities and challenges in targeting HIV entry显示文摘 | MARK J B THEODORE C P ROBERT W D | 2002 | Curr Opin Pharmacol2002，2，： | 1 |
| 20 | Invest ment in human cap ital显示文摘 | Schultz Theodore W | 1961 | American Economic Rview1961，，51： | 1 |
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