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| 1 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
| 2 | Hepatitis C virus therapy with peg-interferon and ribavirin in Myanmar: A resource-constrained country显示文摘AIM To investigate peg-interferon(peg-IFN) and ribavirin(RBV) therapy in Myanmar and to predict sustained virologic response(SVR).METHODS This single-center, open-label, study was conducted in Myanmar between 2009 and 2014. A total of 288 patients infected with HCV genotypes 1, 2, 3 and 6 were treated with peg-IFN alpha-2a(180 μg/wk) or alpha-2b(50 to 100 μg as a weight-based dose) and RBV as a weight-based dose(15 mg/kg/d). Treatment duration was 48 wk for genotypes 1 and 6, 24 wk for genotype 2, and 24 or 48 wk for genotype 3 based on rapid virologic response(RVR). Those co-infected with hepatitis B received 48 wk of therapy.RESULTS Overall, SVR was achieved for 82% of patients and the therapy was well tolerated. All patients achieved SVR at equivalent rates regardless of HCV genotype(P = 0.314). Low fibrosis scores(P < 0.001), high baseline albumin levels(P = 0.028) and low baseline viral loads(P = 0.029) all independently predicted SVR. On the other hand, IL-28 B TT and CC genotypes were not found to significantly predict SVR(P = 0.634; P = 0.618). Among those who completed treatment, the occurrence of RVR showed a > 96% positive predictive value for achieving SVR. Treatment duration did not significantly impact the likelihood of achieving SVR for patients infected with genotype 3 HCV(P = 0.371). The most common adverse events were fatigue(71%) and poor appetite(60%). Among patients with genotype 3 HCV, more patients in the 48-wk treatment group required erythropoietin than in the 24-wk treatment group(61.1% vs 49.2%).CONCLUSION SVR rates were high with peg-IFN and RBV therapy in Myanmar. Fibrosis scores, baseline albumin, HCV RNA levels and RVR independently predicted SVR. | Naomi Khaing Than Hlaing Debolina Banerjee Robert Mitrani Soe Htet Arker Kyaw San Win Nyan Lin Tun Zaw Thant Khin Maung Win K Rajender Reddy | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 3 | 一种考虑损伤的沥青路面本构关系在冲击载荷作用下的应用显示文摘在经典Burgers模型的基础上,基于所有元器件均发生同一程度损伤的假设,引入了与应变和材料参数相关的损伤变量D,建立了可以描述沥青混合料损伤的Burgers模型,用于模拟沥青路面的损伤行为。修正的损伤Burgers模型经过与参考文献中的试验数据对比得到了验证。在此基础上,通过C++软件编程,完成了修正的损伤Burgers模型在FLAC3D数值计算程序中的嵌套开发和应用,计算了某种路面在冲击载荷作用下的弯沉变形和应力分布。结果表明:修正的损伤Burgers模型能够描述冲击载荷作用下沥青路面从加载变形到失稳破坏的整体阶段,计算得到的弯沉盆以及路面和基层的破坏形式与现场试验结果吻合良好,具有较高的精度;通过对计算得到的应力和应变进行后处理,可以获得损伤变量D与应变以及时间的关系曲线,对于评价沥青路面性能具有很好的指导作用;通过采用修正的损伤Burgers模型进行数值计算,在结合现场试验数据的基础上,可以得知低等级公路用于战备使用时,应充分考虑使用前的冲击载荷降压措施,以及使用后的快速修补和维护措施,在可选的情况下,应尽可能选择高等级公路,避免低等级公路段,如三级及以下的公路。 | 冯锦艳 Thant Yee Mon SAN | 2020 | 公路交通科技2020，37，4： | 2 |
| 4 | CD90 is Identified as a Candidate Marker for Cancer Stem Cells in Primary High-Grade Gliomas Using Tissue Microarrays显示文摘 | Jintang He Yashu Liu Thant Zhu Jianhui Zhu Francesco DiMeco Angelo L. Vescovi Jason A. Heth Karin M. Muraszko Xing Fan David M. Lubman | 2012 | Molecular & Cellular Proteomics2012，，6： | 1 |
| 5 | CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays显示文摘 | JINTANG HE YASHU LIU THANT ZHU | 2012 | Mol Cell Proteomics2012，11，6： | 1 |
| 6 | The genetics of sporadic ruptured and uuruptured intracranial aneurysms: a genetic meta-analysis of 8 genes and 13 polymorphisms in approximately 20,000 individuals显示文摘 | McColgan P Thant KZ Sharma P | 2010 | J Neurosurg2010，112，4： | 1 |
| 7 | F-spondin regulates chondrocyte terminal differentiation and endochondral bone formation显示文摘 | Palmer GD Piton AH Thant LM | 2010 | J Orthop Res2010，28，10： | 1 |
| 8 | Constitutive activation of MAP kinase kinase(MEK1) is critical and sufficient for for the activation of MMP-2 显示文摘 | Kurata H Thant AA Matsuo S | 2000 | Exp Cell Res2000，254，1： | 1 |
| 9 | Emerging therapeutic applications of butulinum toxin 显示文摘 | Thant ZS Tan EK | 2003 | Med Sci Monit2003，9，2： | 1 |
| 10 | A role for FAK in the Concanavalin A-dependent secretion of matrix metalloproteinase-2 and-9 显示文摘 | Sein T T Thant A A Hiraiwa Y | 2000 | Oncogene2000，19，48： | 1 |
| 11 | Sequences of E/NS1 gene junction from four Dengue-2 viruses of northeastern Thailand and their evolutionary relationships with other Dengue-2 viruses显示文摘 | Morita K Igarashi A | 1995 | Microbio Immunol1995，39，： | 1 |
| 12 | Constitutive activation of MAP kinase ( MEK1 ) is critical and sufficient for the activation of MMP-2显示文摘 | Kurata H Thant AA Matsuo S | 2000 | Exp Cell Res2000，254，1： | 1 |
| 13 | The genetics of sporadicruptured and unruptured intracranial aneurysms: a geneticmeta-analysis of 8 genes and 13 polymorphisms in approximately20 000 individuals显示文摘 | McColgan P Thant KZ Sharma P | 2010 | J Neurosurg2010，112，4： | 1 |
| 14 | Magnetostriction trend of non-oriented 6.5% Si–Fe显示文摘 | Thant P.P. Phway Anthony J. Moses | 2008 | Journal of Magnetism and Magnetic Materials2008，，20： | 1 |
| 15 | Sequences of E/NS1 gene junctionfrom four Dengue-2 viruses of northeastern Thailand and theirevolutionary relationships with other Dengue-2 viruses 显示文摘 | Thant KZ Morita K Igarashi A | 1995 | Microbio Immunol1995，39，： | 1 |
| 16 | A role for focal adhesion kinase in hyluronan-dependent MMP-2 secretion in a human small cell lung carcinoma cell line 显示文摘 | Zhang Y Thant AA Hiraiwa Y | 2002 | Biochem Biophys Res Commun2002，290，3： | 1 |
| 17 | Cancer invasion and angio-genesis by IGF-1-induced MMP-2 and VEGF in human breast canc-er cells显示文摘 | Thant AA Wu YY Vadgama JV | 2004 | AACR Meeting Abs2004，202，： | 1 |
| 18 | Hyaluronan CD44 signaling regulates matrix metalloproteinase 2 secretion in a human lung carcinoma cell line显示文摘 | Zhang Y Thant AA Machida K | 2002 | Cancer Res2002，62，14： | 1 |
| 19 | The genetics of sporadic ruptured and unruptured intracranial aneurysms: a genetic meta analysis of 8 genes and 13 polymorphisms in approximately 20, 000 individuals 显示文摘 | McColgan P Thant KZ Sharma P | 2010 | J Neurosurg2010，112，： | 1 |
| 20 | Foxo1,a novel regulator of osteoblast differentiation and skeletogenesis 显示文摘 | Teixeira CC Liu Y Thant LM | 2010 | J Biol Chem2010，285，31： | 1 |
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