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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Drug induced acute pancreatitis: Does it exist?显示文摘As the incidence of acute pancreatitis continues to rise, establishing the etiology in order to prevent recurrence is important. Although the etiology of acute pancreatitis is not difficult in the majority of patients, almost a quarter of patients are initially labeled as having idiopathic acute pancreatitis. When confronted with a patient with acute pancreatitis and no clear etiology defined as an absence alcoholism, gallstones(ultrasound and/or MRI), a normal triglyceride level, and absence of tumor, it often appears reasonable to consider a drug as the cause of acute pancreatitis. Over 100 drugs have been implicated by case reports as causing acute pancreatitis. While some of these case reports are well written, many case reports represent poorly written experiences of the clinician simply implicating a drug without a careful evaluation. Over-reliance on case reports while ignoring randomized clinical trials and large pharmacoepidemiologic surveys has led to confusion about drug induced acute pancreatitis. This review will explain that drug induced acute pancreatitis does occur, but it is rare, and over diagnosis leads to misconceptions about the disease resulting in inappropriate patient care, increased litigation and a failure to address the true entity: idiopathic acute pancreatitis. | Scott Tenner | 2014 | World Journal of Gastroenterology2014，20，44： | 6 |
| 3 | Lensless diffractive imaging with ultra-broadbandtable-top sources: from infrared to extreme-ultravioletwavelengths显示文摘Lensless imaging is an approach to microscopy in which a high-resolution image of an object is reconstructed from one or more measured diffraction patterns,providing a solution in situations where the use of imaging optics is not possible.However,current lensless imaging methods are typically limited by the need for a light source with a narrow,stable and accurately known spectrum.We have developed a general approach to lensless imaging without spectral bandwidth limitations or sample requirements.We use two time-delayed coherent light pulses and show that scanning the pulse-to-pulse time delay allows the reconstruction of diffraction-limited images for all the spectral components in the pulse.In addition,we introduce an iterative phase retrieval algorithm that uses these spectrally resolved Fresnel diffraction patterns to obtain high-resolution images of complex extended objects.We demonstrate this two-pulse imaging method with octave-spanning visible light sources,in both transmission and reflection geometries,and with broadband extreme-ultraviolet radiation from a high-harmonic generation source.Our approach enables effective use of low-flux ultra-broadband sources,such as table-top high-harmonic generation systems,for high-resolution imaging. | Stefan Witte Vasco T Tenner Daniel WE Noom Kjeld SE Eikema | 2014 | Light(Science & Applications)2014，3，1： | 5 |
| 4 | Drug-Induced Acute Pancreatitis: An Evidence-Based Review显示文摘 | Nison Badalov Robin Baradarian Kadirawel Iswara Jianjun Li William Steinberg Scott Tenner | 2007 | Clinical Gastroenterology and Hepatology2007，，6： | 2 |
| 5 | Acute pancreatitis : nonsurgical management显示文摘 | Tenner S Banks PA | 1997 | World J Surg1997，21，2： | 1 |
| 6 | Acute pancreatitis显示文摘 | Steinberg W Tenner S | 1994 | N Engl Med1994，33，12： | 1 |
| 7 | Acute pancreatitis: nonsurgical management显示文摘 | Tenner S Banks PA | 1997 | World J Surg1997，21，： | 1 |
| 8 | β-amyloid converts an acute phase injury response to chronic injury显示文摘 | Cotman CW Tenner AJ Cummings | 1996 | Nurobio Ageing1996，17，5： | 1 |
| 9 | Predicting gallstone pancreatitis with laboratory parameters:a meta-analysis显示文摘 | Tenner S Dubner H Steinberg W | | 0，，10： | 1 |
| 10 | Complement proteins Clq and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions显示文摘 | Fraser DA Tenner AJ | 2007 | Mol Immunol2007，44，13： | 1 |
| 11 | Acute pancreatitis显示文摘 | Steinberg W Tenners S | 1994 | N Engl J Med1994，330，： | 1 |
| 12 | Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitides serogroup B显示文摘 | Read RC Tenner AJ | 2001 | J Infect Dis2001，184，9： | 1 |
| 13 | Acute pancreatitis显示文摘 | SteinGerg W Tenner S | 1994 | N Engl J Med1994，330，： | 1 |
| 14 | Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm显示文摘 | Tenner MS Gottfried ON | 2004 | J Neurosurg2004，100，： | 1 |
| 15 | Acute Pancreatitis 显示文摘 | Steinbey W Tenner S | 1994 | N Eng J Med1994，330，： | 1 |
| 16 | A health-care data model based on the HL7 Reference Information Model显示文摘 | Eggebraaten T J Tenner J W Dubbels J C | 2007 | IBM System Journal2007，46，1： | 1 |
| 17 | The role of the anaphylatoxins in health and disease显示文摘 | Klos A Tenner A J Johswich K O | 2009 | Mol Immunol2009，46，14： | 1 |
| 18 | Reversal of radiographically impending stroke with multiple intraarterial papaverine infusions in severe diffuse cerebral vasospasm induced by subarachnoid hemorrhage显示文摘 | Tenner MS Oestreich HM | 2001 | Acta Neurochir (wien)2001，143，： | 1 |
| 19 | Acutepancreatitis:nonsurgicalmanagement显示文摘 | TennerS BanksPA | 1997 | WorldJSurg1997，21，： | 1 |
| 20 | Efficacy of multiple intraarterial papaverine infusions for improvement in cerebral circulation time in patients with recurrent cerebral vasospasm显示文摘 | LIU JK TENNER MS GOTrFRIED ON | 2004 | J Neurosurg2004，100，： | 1 |
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