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| 1 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 2 | Dorsal branches of superficial radial nerve:an anatomic study with potential clinical applications显示文摘 | Tellioglu A T Tekdemir I Ersoy M | 2000 | Eur J Plast Surg2000，23，： | 2 |
| 3 | Temporoparietal fascia:an anatomic and histologic reinvestigation with new potential clinical applications显示文摘 | Tellioglu A Tekdemir I ErdemliEA | 2000 | Plast Reconstr Surg2000，105，： | 1 |
| 4 | Temporoparietal fascia : an anatomic and histologic reinvestigatian with new potential clinical applications 显示文摘 | Tellioglu AT Tekdemir I Erdemli EA | 2000 | Plast Reconstr Surg2000，105，： | 1 |
| 5 | The dorsal branch of the digital nerve:an anatomic study and clinical applications显示文摘 | Tellioglu AT Sensoz O | 1998 | Ann Plast Surg1998，40，： | 1 |
| 6 | Ankylosing spondylitis and multiple sclerosis in an HLA-B27 negative patient显示文摘 | Tan FU Tellioglu S Aydin G | 2004 | Acta Neurol Belg2004，104，4： | 1 |
| 7 | Temporoparietal fascia:an anatomic and histologic reinvcstigation with new potential clinical applications显示文摘 | Tellioglu AT Tekdemir L Erdemli EA | 2000 | Plast Reconstr Surg2000，105，1： | 1 |
| 8 | Upper lip augmentation with doub-le-row subcutaneous pedicled V-Y flaps in Mobius syn-drome显示文摘 | Eker E Tellioglu AT | | 0，，5： | 1 |
| 9 | Comparison of laparoscopic transabdominal lateral versus posterior retroperitoneal adrenalectomy显示文摘 | Berber E Tellioglu G Harvey A | 2009 | Surgery2009，146，4： | 1 |
| 10 | Comparison of laparoseopie transabdominal lateral versus posterior retroper- itoneal adrenaleetomy显示文摘 | BERBER E TELLIOGLU G HARVEY A | 2009 | Surgeryi2009，146，4： | 1 |
| 11 | Reconstruction of proximal nasal defects with island composite nasal flaps 显示文摘 | Tellioglu AT Tekdemir I Saray A | 2005 | Plast Reconstr Surg2005，115，2： | 1 |
| 12 | Resection versus laparoscopic radiofrequency thermal ablation of solitary colorectal liver metastasis显示文摘 | Berber E Tsinberg M Tellioglu G | 2008 | J Gastrointest Surg2008，12，11： | 1 |
| 13 | Temporoparietal fascia:an anatomic and histologic reinvestigation with new potential clinical applications显示文摘 | Tellioglu A T Tekdemir I Erdemli E A | 2000 | Plast Reconstr Surg2000，105，1： | 1 |
| 14 | Temoproparietal fascia plieation in rhytidectomy显示文摘 | Tellioglu AT Hosaka Y | 2006 | Aesth Plast Surg2006，30，： | 1 |
| 15 | Surgical treatment of urologic complications after renal transplantation显示文摘 | Yigit B Tellioglu G Berber I | 2008 | Transplantation Proceedings2008，40，6： | 1 |
| 16 | Comparison of laparoscopic transabdominal lateral versus posterior retroperitoneal adrenalectomy 显示文摘 | Berber E Tellioglu G Harvey A | 2009 | Surgery2009，146，4： | 1 |
| 17 | The dorsal borsal branch of the digital nerve:an anatomic study and clinical applications 显示文摘 | Tellioglu AT Sensoz O | 1998 | Ann Plast Surg1998，40，： | 1 |
| 18 | Doppler ultrasonography-guided surgery for high-flow hemodialysis vascular access : preliminary results显示文摘 | Tellioglu G Berber I Kilicoglu G | 2008 | Transplant Proc2008，40，1： | 1 |
| 19 | Quality of Life Analysis of Renal Donors显示文摘 | G. Tellioglu I. Berber I. Yatkin B. Yigit T. Ozgezer S. Gulle G. Isitmangil M. Caliskan I. Titiz | 2008 | Transplantation Proceedings2008，，1： | 1 |
| 20 | Resection versus laparoscopic radiofrequency thermal ablation of solitary colorectal liver metastasis显示文摘 | BERBER E TSINBERG M TELLIOGLU G | 2008 | J Gastrointest Surg2008，12，11： | 1 |
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