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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 3 | Maryland's Green Infrastructure Assessment:Development of a comprehensive approach to land conservation显示文摘 | Ted W Anne S John W | | 0，，： | 1 |
| 4 | Environmental influence on behavior and nerve growth factor in the brain 显示文摘 | Mohammed AK Bengt W Ted E | 1990 | Brain Research1990，528，： | 1 |
| 5 | Maryland's Green Infrastructure Assessment: Development of a comprehensive approach to land conservation显示文摘 | TED W SLOAN A | | Landscape and Urban Planning0，77，12： | 1 |
| 6 | Molybdenum phosphide: a novel catalyst for hydrodeuitrogenation显示文摘 | Li W Dhandapani B Ted O S | 1998 | Chem Lett1998，1998，3： | 1 |
| 7 | Chaos in ocean ambient ‘noise’显示文摘 | Ted W Frison Henry D I Aharbanel Joan Cernbrola BertNeales | 1996 | J Acoust Soc Am1996，99，3： | 1 |
| 8 | A Multifeature Decision Space Approach to Radar Target Identifiea- tion显示文摘 | Ted J G Gorman R P Berger W A | 1996 | IEEE Trans on Aerospace and Electronic Sys*ems1996，32，1： | 1 |
| 9 | , a critical role of IRF-I显示文摘 | JARUGA B HONG F KIM W H et aL IFN-gamma/ STAT 1 acts as a proinflamrnatory signal in T cell-media- ted hepatitis via induction of multiple chemokines and ad- hesion molecules | 2004 | Am J Physiol Gastrointest Liver Physiol2004，287，： | 1 |
| 10 | Optimizing protein extraction from plant tissues for enhanced proteomics analysis显示文摘 | Wang W Ted F Chen S | 2008 | J Sep Sci2008，31，： | 1 |
| 11 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet2013，，9867： | 1 |
| 12 | Adsorption studies of natural gas storage in Devonian shales显示文摘 | Xiao Chun L Fan Chang L Ted W A | | 0，，02： | 1 |
| 13 | Expansion of the fragile X CGG repeat in females with pre-mutation or intermediate alleles显示文摘 | Sarah L Nolin W Ted Brown | 2003 | Am J Hum Genet2003，72，： | 1 |
| 14 | Computer-aided diagnosis of lung nodules on CT scans:ROC study of its effect on radiologists' performance显示文摘 | Ted W Heang-Ping C Lubomir H | 2010 | Acad Radiol2010，17，3： | 1 |
| 15 | Manipulated Synchronization: Beam Steering in Phased Arrays 显示文摘 | Ted H Kurt W Robert A Y | 2000 | Int J Bifurc Chaos (S0218-1274)2000，10，11： | 1 |
| 16 | The effect of exposure of the H-storage system(Li NH2+Mg H2)to watersaturated air显示文摘 | Luo S Flanagan Ted B Luo W | 2007 | Journal of Alloys and Compounds2007，440，： | 1 |
| 17 | Valproic acid inhibits growth induces apoptosis, and modulates apoptosis-regulatory and dif fcrentiation gene expression in human thyroid cancer cells显示文摘 | Wentao S Mei D Teds W | 2005 | Surgery2005，6，138： | 1 |
| 18 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet2013，，9867： | 1 |
| 19 | Recent improvements in SPH modeling of hypervelocity impact 显示文摘 | Larry Libersky D Phil Randles W Ted Carney C David Dickinson L | 1997 | International Journal of Impact Engineering1997，20，： | 1 |
| 20 | Landscape ecological assessment of the Chesapeake bay watershed显示文摘 | TED W | 2004 | Environmental Monitoring and Assessment2004，94，13： | 1 |
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