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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Charaterization of novel eircovims DNAs associated with wasting Syn- dromes in pigs显示文摘 | Mechan B M McNeilly F Ted D | 1998 | J Gen Viral1998，79，： | 1 |
| 3 | Market-oriented health care reforms and policy learning in the Netherlands显示文摘 | Helderman J K Schut F T van de Grinten TED | 2005 | Journal of Health Politics Policy and Law2005，30，12： | 1 |
| 4 | , a critical role of IRF-I显示文摘 | JARUGA B HONG F KIM W H et aL IFN-gamma/ STAT 1 acts as a proinflamrnatory signal in T cell-media- ted hepatitis via induction of multiple chemokines and ad- hesion molecules | 2004 | Am J Physiol Gastrointest Liver Physiol2004，287，： | 1 |
| 5 | Optimizing protein extraction from plant tissues for enhanced proteomics analysis显示文摘 | Wang W Ted F Chen S | 2008 | J Sep Sci2008，31，： | 1 |
| 6 | 显示文摘 | Clair Todd P St Oyama S Ted Cox David F | 1999 | Surface Science1999，426，2： | 1 |
| 7 | Nitric oxide synthase in models of focal Ischemia显示文摘 | Amer F Ted M Valina L | 1997 | Stroke1997，28，： | 1 |
| 8 | Tectonic wedging, back-thrusting and basin development in the frontal parts of the Mesoproterozoic Karagwe - Ankole belt in NW Tanzania显示文摘 | elopment events 2012 KOEGELENBERG C KISTERS A F M | 2014 | Journal of African Earth Sciences2014，97，： | 1 |
| 9 | Shear strengthening of reinforeed concrete beams using extemally applied composite fabries显示文摘 | Chajes M J Ted F Januszka | 1995 | ACI Struetural Joumal1995，87，： | 1 |
| 10 | Credit assigned CMAC and its application to online learning robust controllers显示文摘 | Shun F S Ted T Hung T H | 2003 | IEEE Trans on Systems Man and Cybernetics2003，333，2： | 1 |
| 11 | Kinetic model for photocatalytic degradation of organic contaminants in a thin-film TiO2 catalyst显示文摘 | Ted C H Wu N M Zhu F Q | 2000 | Water Research2000，34，2： | 1 |
| 12 | Mapping and monitoring electrical resistivity with surface and subsurface electrode arrays显示文摘 | ASCH Ted and MORRISON H F | 1989 | Geophysics1989，54，2： | 1 |
| 13 | Renin increases mesangi& B, and m&trix proteins through receptor- mech&nisms显示文摘 | Huang Y Wongamorntham cell tr&nsforming growth f&ctor medi&ted angiotensin II-independent ]15 $ Kasting J et &l | 2006 | Kidney Int2006，69，1： | 1 |
| 14 | Characterization of novel circovirus DNAs associated with wasting syndromes in pigs显示文摘 | MEEHAN B M MCNEILLY F TED D | 1998 | J Gen Virol1998，79，9： | 1 |
| 15 | Charaterization of novel circovirus DNAs associated with wasting Syndromes in pigs显示文摘 | Meehan BM MeNeilly F Ted D | 1998 | J Gen Virol1998，79，： | 1 |
| 16 | Credit Assigned CMAC and Its Ap- plication to Online Learning Robust Controllers显示文摘 | Shun F S Ted T Huang T H | 2003 | IEEE Transac- tions on Systems Man and Cybernetics Part B: Cybernetics2003，33，2： | 1 |
| 17 | Nitric oxidesynthase in models of focal ischemia 显示文摘 | Amer F Samdani MD Ted M | 1997 | Stroke1997，28，6： | 1 |
| 18 | Studies of the effect of pressure and hydrogen permeance on the ethanol steam reforming reaction with palladium-and silica-based membranes显示文摘 | Lim H Gu Y F Ted Oyama S | 2012 | Journal of Membrane Science2012，396，： | 1 |
| 19 | Three - dimensional results for an electrical hole - to - surface method: application to the interpretation of field survey 显示文摘 | Le Masne Poirmeur Asch Ted Mprrison H F | 1987 | Geophysics1987，52，4： | 1 |
| 20 | Carbon and nitrogen pools of southern high plains cropland and grassland soils显示文摘 | KEVIN F B TED M Z TERESITA T C | 2004 | Soil Science Society of America Journal2004，68，5： | 1 |
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