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| 1 | Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury显示文摘AIM To investigate the hepatic microcirculatory changes due to Haemoxygenase(HO),effect of HO inhibition on remote ischemic preconditioning(RIPC) and modulation of CINC.METHODS Eight groups of animals were studied- Sham,ischemia reperfusion injury(IRI) the animals were subjected to 45 min of hepatic ischemia followed by three hours of reperfusion,RIPC(remote ischemic preconditioning) + IRI group,remote ischemic preconditioning in sham(RIPC + Sham),PDTC + IR(Pyridodithiocarbamate,HO donor),Zn PP + RIPC + IRI(Zinc protoporphyrin prior to preconditioning),IR-24(45 min of ischemia followed by 24 h of reperfusion),RIPC+IR-24(preconditioning prior to. After 3 and 24 h of reperfusion the animals were killed by exsanguination and samples were taken. RESULTS Velocity of flow(160.83 ± 12.24 μm/s),sinusoidal flow(8.42 ± 1.19) and sinusoidal perfusion index(42.12 ± 7.28) in hepatic IR were lower(P < 0.05) in comparison to RIPC and PDTC(HO inducer). RIPC increased velocity of flow(328.04 ± 19.13 μm/s),sinusoidal flow(17.75 ± 2.59) and the sinusoidal perfusion index(67.28 ± 1.82)(P < 0.05). PDTC(HO induction) reproduced the effects of RIPC in hepatic IR. PDTC restored RBC velocity(300.88 ± 22.109 μm/s),sinusoidal flow(17.66 ± 3.71) and sinusoidal perfusion(82.33 ± 3.5) to near sham levels. Zn PP(HO inhibition) reduced velocity of flow of RBC in the RIPC group(170.74 ± 13.43 μm/s and sinusoidal flow in the RIPC group(9.46 ± 1.34). Zn PP in RIPC(60.29 ± 1.82) showed a fall in perfusion only at 180 min of reperfusion. Neutrophil adhesion in IR injury is seen in both postsinusoidal venules(769.05 ± 87.48) and sinusoids(97.4 ± 7.49). Neutrophil adhesion in RIPC + IR injury is reduced in both postsinusoidal venules(219.66 ± 93.79) and sinusoids(25.69 ± 9.08)(P < 0.05). PDTC reduced neutrophil adhesion in both postsinusoidal venules(89.58 ± 58.32) and sinusoids(17.98 ± 11.01)(P < 0.05) reproducing the effects of RIPC. Zn PP(HO inhibition) increased venular(589.04 ± 144.36) and sinusoidal neutrophil adhesion in preconditioned animals(121.39 ± 30.65)(P < 0.05). IR after 24 h of reperfusion increased venular and sinusoidal neutrophil adhesion in comparison to the early phase and was significantly reduced by RIPC. Hepatocellular cell death in IRI(80.83 ± 13.03),RIPC + IR(17.35 ± 2.47),and PTDC+IR(11.66 ± 1.17) Zn PP + RIPC + IR(41.33 ± 3.07) reduced hepatocellular death. Zn PP significantly increased hepatocellular death(P < 0.05 PTDC/RIPC vs Zn PP and IR). The CINC cytokine levels in sham(101.32 ± 6.42). RIPC + sham(412.18 ± 65.24) as compared to sham(P < 0.05). Hepatic IR(644.08 ± 181.24)(P < 0.05). RIPC CINC-1 levels in the early phase(401.62 ± 78.56). And PDTC(HO inducer) CINC-1 levels in hepatic IR(413.36 ± 63.06) were significantly lower. HO inhibition in preconditioned animals with Zinc protoporphyrin increased serum CINC levels(521.81 ± 74.9)(P < 0.05). The serum CINC levels were high in the late phase of hepatic IR(15306 ± 1222.04). RIPC reduced CINC levels in the late phase of IR(467.46 ± 26.06),P < 0.05.CONCLUSION RIPC protects hepatic microcirculation by induction of HO and modulation of CINC in hepatic IR. | Niteen Tapuria Sameer Junnarkar Mahmoud Abu-amara Barry Fuller Alexander M Seifalian Brian R Davidson | 2016 | World Journal of Gastroenterology2016，22，33： | 3 |
| 2 | Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury-a review 显示文摘 | Tapuria N Kumar Y Habib MM | 2008 | J Surg Res2008，150，2： | 1 |
| 3 | Tumor M2-pyiuvate ki- nase: a gastrointestinal cancer marker 显示文摘 | Kumar Y Tapuria N Kimani N | 2007 | Eur J Gastroenter- ol Hepatol2007，19，3： | 1 |
| 4 | Liver ischemi-a/reperfusion injury: processes in inflammatory networks -a re-view显示文摘 | ABU -AMARA M YANG SY TAPURIA N | 2010 | Liver Transpl2010，16，9： | 1 |
| 5 | Liver Isehemia/Reperfusion Injury: Processes in Inflammatory Net- works- A Review 显示文摘 | Mahmoud Abu-Amara Shi Yu Yang Niteen Tapuria | 2010 | Liver Transplantation2010，16，： | 1 |
| 6 | LiverIschemia/Reperfusion Injury : Processes in Inflammatory Networks-A Review显示文摘 | Mahmoud Abu - Amara Shi Yu Yang Niteen Tapuria | 2010 | Liver Transplantation2010，16，： | 1 |
| 7 | Effect of remote ischemie preconditioning on hepatic microcirculation and function in a rat model of hepatic isehemia reperfusinn injury显示文摘 | Tapuria N Junnarkar SP Dutt N | 2009 | HPB2009，1，2： | 1 |
| 8 | Tumour M2-pyruvate kinase: a gastrointestinal cancer marker 显示文摘 | Kumar Y Tapuria N Kirmani N | 2007 | Eur J Gastroenterol Hepatol2007，19，3： | 1 |
| 9 | Remote ischemic preconditioning:a novel protective method from ischemia reperfusion injury-a review显示文摘 | Tapuria N Kumar Y Habib MM | 2008 | J Surg Res2008，150，2： | 1 |
| 10 | Tumour M2-pyruvale kinase: a gastrointestinal cancer marker显示文摘 | Kumar Y Tapuria N Kirmani N | 2007 | Eur J Gastroenterol Hepatol2007，19，： | 1 |
| 11 | Effect of remote ischemic preconditioning on liver ischemia/reperfusion injury using a new mouse model显示文摘 | Mahmoud Abu‐Amara Shi Yu Yang Alberto Quaglia Peter Rowley Niteen Tapuria Alexander M. Seifalian Barry J. Fuller Brian R. Davidson | 2011 | Liver Transpl2011，，1： | 1 |
| 12 | Remote Ischemic Preconditioning: A Novel Protective Method From Ischemia Reperfusion Injury—A Review显示文摘 | Niteen Tapuria Yogesh Kumar Meer Mohammad Habib Mahmoud Abu Amara Alexander M. Seifalian Brian R. Davidson | 2008 | Journal of Surgical Research2008，，2： | 1 |
| 13 | Liver isehemia/reperfu- sion injury: processes In inflammatory networks -a review显示文摘 | Abu-Amara M Yang SY Tapuria N | 2010 | Liv- er Transp12010，16，9： | 1 |
| 14 | Effect of remote ischemic preconditioning on hepatic microcirculation and function in a rat model of hepatic ischemia reperfusion injury显示文摘 | Tapuria N Junnarkar SP Dutt N | 2009 | HPB2009，11，2： | 1 |
| 15 | Liver ischemia/reperfusion injury:processes in inflammatory networks--a review显示文摘 | Abu-Amara M Yang SY Tapuria N | | 0，，09： | 1 |
| 16 | Liver ischemia/reper- fusion injury: processes in inflammatory networks--a review显示文摘 | Abu-Amara M Yang SY Tapuria N | 2010 | Liver Transpl2010，16，9： | 1 |
| 17 | Remote Ischemic Preconditioning: A Novel Protective Method From Ischemia Reperfusion Injury—A Review显示文摘 | Niteen Tapuria Yogesh Kumar Meer Mohammad Habib Mahmoud Abu Amara Alexander M. Seifalian Brian R. Davidson | 2008 | Journal of Surgical Research2008，，2： | 1 |
| 18 | Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury - a review显示文摘 | Tapuria N Kumar Y Habib MM | 2008 | J Surg Res2008，150，2： | 1 |
| 19 | TumorM2-pyruvatekinase: a gastrointestinal cancer marker显示文摘 | Kumar Y Tapuria N Kirmani N | 2007 | Eur J Gastroenterol Hepatol2007，19，3： | 1 |
| 20 | Remote ischemic pre-conditioning:a novel protective method from ischemia reperfu-sion injury-a review显示文摘 | Tapuria N Kumar Y Habib MM | 2008 | J Surg Res2008，150，2： | 1 |
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