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| 1 | 膜联蛋白A2与肿瘤进展的相关性显示文摘膜联蛋白A2(ANXA2)是众所周知的钙离子依赖性磷脂结合蛋白,广泛分布于各种真核细胞的胞核、胞质及细胞外膜。它作为功能多样的蛋白质影响多种细胞和分子功能活动。ANXA2的表达或调节失常涉及一系列疾病,包括自身免疫性疾病、神经系统退行性变、抗磷脂抗体综合征、炎症、糖尿病及各种肿瘤。 | 侯俊杰 周颖 谭岩 方艳秋 许一多 | 2015 | 中国免疫学杂志2015，31，11： | 9 |
| 2 | 骨髓单个核细胞移植对大鼠溃疡性结肠炎的作用显示文摘目的:探讨同种异体骨髓单个核细胞(BM-MNCs)移植大鼠溃疡性结肠炎模型的作用。方法:将DAPI标记的同种异体大鼠骨髓单个核细胞(BM-MNCs)经尾静脉注射移植到大鼠溃疡性结肠炎(UC)模型体内(模型组),以尾静脉注射等量PBS的UC大鼠作为对照组。光镜观察大鼠结肠组织病变改变,荧光显微镜观察标记DAPI的BM-MNCs在结肠组织中的定植及分布情况,免疫荧光检测BM-MNCs中CK19、CD34的表达情况。结果:移植组大鼠结肠组织可见新生黏膜上皮及腺体,黏膜下有新鲜至成熟肉芽组织生成,明显优于对照组;移植14天,大鼠结肠组织中可观察到DAPI标记的BM-MNCs细胞;DAPI标记的细胞可表达血管内皮细胞特异性表达蛋白CD34或黏膜上皮细胞特异性表达蛋白CK19。结论:BM-MNCs可向受损病变部位结肠组织迁移和定植,且分化为血管内皮细胞和黏膜上皮细胞。 | 陈刚 邱冰 颜玉 鲍秀琦 韩宇鹏 吴宇 王雪 姜威 | 2018 | 现代生物医学进展2018，18，1： | 2 |
| 3 | A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing显示文摘Vogt–Koyanagi–Harada(VKH)disease is a leading cause of blindness in young and middle-aged people.However,the etiology of VKH disease remains unclear.Here,we performed the first trio-based whole-exome sequencing study,which enrolled 25 VKH patients and 50 controls,followed by a study of 2081 VKH patients from a Han Chinese population to uncover detrimental mutations.A total of 15 de novo mutations in VKH patients were identified,with one of the most important being the membrane palmitoylated protein 2(MPP2)p.K315N(MPP2-N315)mutation.The MPP2-N315 mutation was highly deleterious according to bioinformatic predictions.Additionally,this mutation appears rare,being absent from the 1000 Genome Project and Genome Aggregation Database,and it is highly conserved in 10 species,including humans and mice.Subsequent studies showed that pathological phenotypes and retinal vascular leakage were aggravated in MPP2-N315 mutation knock-in or MPP2-N315 adeno-associated virus-treated mice with experimental autoimmune uveitis(EAU).In vitro,we used clustered regularly interspaced short palindromic repeats(CRISPR‒Cas9)gene editing technology to delete intrinsic MPP2 before overexpressing wild-type MPP2 or MPP2-N315.Levels of cytokines,such as IL-1β,IL-17E,and vascular endothelial growth factor A,were increased,and barrier function was destroyed in the MPP2-N315 mutant ARPE19 cells.Mechanistically,the MPP2-N315 mutation had a stronger ability to directly bind to ANXA2 than MPP2-K315,as shown by LC‒MS/MS and Co-IP,and resulted in activation of the ERK3/IL-17E pathway.Overall,our results demonstrated that the MPP2-K315N mutation may increase susceptibility to VKH disease. | Xianyang Liu Jiayu Meng Xingyun Liao Yusen Liu Qian Zhou Zongren Xu Shuming Yin Qingfeng Cao Guannan Su Siyuan He Wanqian Li Xiaotang Wang Guoqing Wang Dali Li Peizeng Yang Shengping Hou | 2023 | Cellular & Molecular Immunology2023，20，11： | 0 |
| 4 | ANXA2介导的免疫反应在肠黏膜屏功能障碍中的研究进展显示文摘由于胃肠道在人体器官功能的作用中扮演着消化和免疫的双重重要角色,在危重症疾病的应激作用下容易出现胃肠功能障碍(gastrointestinal dysfunction,GID),并且出现常提示危重症患者的病情恶化[1]。急性胃肠损伤(acute gastrointestinal injury,AGI)是危重症患者在急性疾病(如休克、重症感染、严重烧伤、严重颅脑损伤等)应激情况下因机体发生缺血、缺氧、微循环功能障碍等导致的[2],病情危急的可进展为胃肠功能衰竭。 | 张琪 张馗 通耀威 姜梦娜 宋云林 | 2023 | 中华急诊医学杂志2023，32，5： | 0 |
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