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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Discrepancy in the preferences of place of death between terminally ill cancer patienls and their primary family caregivers in Taiwan显示文摘 | Tang ST Liu TW Lai MS | 2005 | Soc Sci Mecl2005，61，7： | 1 |
| 3 | The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma 显示文摘 | CHI-MAN TANG T TUNG-PING POON R FAN ST | 2005 | Biomed Pharmacother2005，59，2： | 1 |
| 4 | Increased level oflL-32 during human immunodeficiency virus infection suppresses HIV replication 显示文摘 | Rasool ST Tang H Wu J | 2008 | Immunol Lett2008，117，2： | 1 |
| 5 | Predictive chemotherapy of advanced breast cancer directed by MTT assay in vitro 显示文摘 | Xu JM Song ST Tang ZM | 1999 | Breast Cancer Res Treat1999，53，1： | 1 |
| 6 | Discrepancy in the preferences for place of death between terminally ill patients and their primary family caregivers in Taiwan显示文摘 | Tang ST Liu TW Lai MS | 2005 | Soc Sci Med2005，61，： | 1 |
| 7 | Minimally differentiated acute myeloid leukemia in Taiwan: predominantly occurs in children less than 3 years and adults between 51 and 70 years显示文摘 | Huang SY Tang JL Jou ST | 1999 | Leukemia1999，13，10： | 1 |
| 8 | Single-incision laparoscopic versus conventional laparoscopic endorectal pull-through for Hirschsprung' s disease: A comparison of short-term surgical results 显示文摘 | Tang ST Yang Y Li SW | 2013 | J Pediatr Surg2013，48，9： | 1 |
| 9 | Meaning of dying at home for Chinese patients in Taiwan with terminal cancer:a literature review显示文摘 | Tang ST | 2000 | Canc Nurs2000，23，5： | 1 |
| 10 | Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication显示文摘 | Rasool ST Tang H Wu J | 2008 | Immunol lett2008，117，2： | 1 |
| 11 | Epiga]locatechin-3- gallate induced primary cultures of rat hippocampa] neurons death linked to calcium overload and oxidative stress显示文摘 | Yin ST Tang ML Deng HM | 2009 | NaunynSchmiedeberg''s Arch Pharmacol2009，379，： | 1 |
| 12 | Community-based interventions in hypertensive patients: a comparison of three health education strategies 显示文摘 | Lu CH Tang ST Lei YX | 2015 | BMC Public Health2015，15，1： | 1 |
| 13 | Laparoscopic choledochal cyst excision, hepaticojejunostomy, and extracorporeal Roux-en-Y anastomosis: a technical skill and intermediate-term report in 62 cases 显示文摘 | Tang ST Yang Y Wang Y | 2011 | Surg Endosc2011，25，2： | 1 |
| 14 | Endoscopic transaxillary ap- proach for congenital muscular torticollis 显示文摘 | Tang ST Yang Y Mao YZ | 2010 | J Pediatr Surg2010，45，11： | 1 |
| 15 | Optimisation of antioxidant peptide from com gluten meal显示文摘 | Zhuang H Tang N Dong ST | 2013 | Journal of the Science of Food and Agriculcural(2013，93，13： | 1 |
| 16 | Calcified, minimally fat - contained an- giomyolipoma clinically indistinguishable from a renal cell carcino- ma显示文摘 | Chen Sh Tang ST Wu En | 2013 | BMC nephrology2013，14，12： | 1 |
| 17 | Single-incision laparoscopic versus conventional laparoscopic endorectal pull- through for Hirschsprung's disease: a comparison of short-term surgical results 显示文摘 | Tang ST Yang Y Li SW | 2013 | J Pediatr Surg2013，48，9： | 1 |
| 18 | Laparoscopic extensive colectomy with transanal Soave pull - through for intestinal neuronal dysplasia in 17 children 显示文摘 | Tang ST Yang Y Wang GB eta1 | 2010 | WoAd J Pediatr2010，6，1： | 1 |
| 19 | Course and predictors of depressive symptoms among family caregivers of terminally Ⅲ cancer patients until their death显示文摘 | Tang ST Chang WC Chen JS | 2013 | Psych oncology2013，22，6： | 1 |
| 20 | Predictive chemotherapy of advanced breast cancer directed by MTT assay in vitro显示文摘 | Xu JM Song ST Tang ZM | 1999 | Breast Cancer Res Treat1999，53，1： | 1 |
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