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| 1 | On self-nonself discrimination in pattern recognition显示文摘Wide distribution and broad reactivity are cardinal features of pattern recognition receptors that allow rapid mobiliza-tion of large numbers of effectors to deal with pathogens.However, these features come with significant baggage as the receptors have been shown to interact with many intra-cellular components, collectively called | LIU Yang1,2,CHEN GuoYun2,ZHENG Pan2 & TANG Jie11 Key Laboratory of Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2Departments of Surgery,Internal Medicine and Pathology,University of Michigan at Ann Arbor,MI48109,USA | 2010 | Science China(Life Sciences)2010，53，2： | 7 |
| 2 | VEGF-specific siRNAs modified with 2′-deoxy effectively suppress VEGF expression and inhibit growth of nasopharyngeal carcinoma xenograft in a mouse model显示文摘Vascular endothelial growth factor (VEGF) is up-regulated in the vast majority of human tumors. The up-regulation of VEGF not only plays important roles in tumor angiogenesis, but also provides a target for tumor treatment with small interfering RNA (siRNA) that targets VEGF; however, it is unclear whether a quite high up-regulation of VEGF will affect the efficiency of RNA interference strategies targeting VEGF. A high level expression of VEGF was found in CNE cells from a nasopharyngeal carcinoma cell line. In this study, we investigate whether VEGF-specific siRNAs can effectively suppress VEGF expression in CNE cells, and study the methods for the use of VEGF-specific siRNAs as potential therapeutic agents. CNE cells with high VEGF expression induced by hypoxia were transfected with VEGF-specific siRNAs. The expression of VEGF was effectively suppressed by VEGF-specific siRNAs, measured by ELISA, Western blot analysis and RT-PCR. Furthermore, experiments in nude mice bearing nasopharyngeal carcinoma xenograft were initiated 5 d after injection of CNE cells. VEGF-specific siRNAs were modified with 2′-deoxy, then injected into the tumors, and a liposome-mediated siRNA transfection system and ultrasound exposure were used to help delivery of the siRNAs. Tumor growth was reduced significantly after 3 weeks' treatment. These studies suggest that VEGF-specific siRNAs still can effectively suppress VEGF expression even in tumor cell lines with a relatively high level of VEGF expression, such as CNE, and VEGF-specific siRNAs modified with 2′-deoxy can be used as potential agents for tumor therapy. | CHEN ShanYi1, GAO GuoFeng1, CHEN Wei1, Lü Qing2, TANG Shen2, HUA Zhong2, YE WenBin2, GU DaYong2, WANG ShaYan1 & ZHANG YaOu2 1 Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen 518020, China 2 Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2008 | Science China(Life Sciences)2008，51，2： | 6 |
| 3 | A novel synthetic route for LiFePO_4/C cathode materials by addition of starch for lithium-ion batteries显示文摘LiFePO4/Carbon composite cathode material was prepared using starch as carbon source by spray-pelleting and subsequent pyrolysis in N2. The samples were characterized by XRD, SEM, Raman, and their electrochemical performance was investigated in terms of cycling behavior. There has a special micro-morphology via the process, which is favorable to electrochemical properties. The discharge capacity of the LiFePO4.C composite was 170 mAh g-1, equal to the theoretical specific capacity at 0.1 C rate. At 4 C current density, the specific capacity was about 80 mAh g-1, which can satisfy for transportation applications if having a more flat discharge flat. | Shao Hua Luo, Zi Long Tang, Jun Biao Lu, Zhong Tai Zhang State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2007 | Chinese Chemical Letters2007，18，2： | 5 |
| 4 | Equal contributions anti credit given to authors in critical care medicine journals during a 10-yr )eriod显示文摘 | Wang F Tang L Bo L L et at | 2012 | Critieal Care Medieine2012，40，3： | 1 |
| 5 | Novel application of vacuum assisted closure technique to the treatment of sternotomy wound infection 显示文摘 | Tang AT Ohri SK Haw MP | 2000 | Eur J Cardiothorac Surg2000，17，4： | 1 |
| 6 | Hepatocyte growth fac- tor (HGF) upregulates heparanase expression via the PI3K/Akl/ NF-K B signaling pathway for gastric cancer metastasis显示文摘 | HAO N B TANG B WANG G Z et at | 2015 | Can- cer Lett2015，361，1： | 1 |
| 7 | Strength analysis of bamboo by microscopic investigation of bamboo fiber 显示文摘 | Tommy Y L Cui H Z Tang P W C at el | 2008 | Con- struction and Building Materials2008，22，： | 1 |
| 8 | Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy alone显示文摘 | Yeh SA Tang Y Lui CC et at | | 0，，03： | 1 |
| 9 | Inhibitory effect of mieroRNA-34a on retinal pigment epithelial cell proliferation and migration 显示文摘 | Hou Q Tang J Wang Z et at | 2013 | Invest Ophthalmol Vis Sci2013，54，10： | 1 |
| 10 | Molecular diagnosis of Prader-Willi and Angelman syndromes by methylation-specific melting analysis and methylation-specific multiplex ligation-dependent probe amplification 显示文摘 | Procter M Chou L S Tang W at al | 2006 | Clin Chem2006，52，7： | 1 |
| 11 | Overexpreession of lymphangiogenic growth factor VEGF-C in human pancreatic Cancer显示文摘 | Tang RF Itakura J A Kaw aT | 2001 | Pancreas2001，22，3： | 1 |
| 12 | Simultaneous formation of nanoerystalline and (100) textured and { 111 } facet dominated microcrystalline diamond films using CH4/H2/O2 plasma 显示文摘 | TANG C J FERNANDES A J JIANG X F et at | 2012 | Dia- mond and Related Materials2012，24，： | 1 |
| 13 | Chondroblastoma of bone 显示文摘 | Ramappa AT Lee FY Tang P | 2000 | Bone Jonit Surg2000，，： | 1 |
| 14 | Role of HCN channels in neuronal hyperexcitability after subarachnoid hemorrhage in rats显示文摘 | LI B LUO C TANG W et at | 2012 | J Neurosci2012，32，9： | 1 |
| 15 | A prospective,randomised trial comparing closed intramedullary nailing with percutaneous plating in the treatment of distal metaphyseal fractures of the tibia 显示文摘 | Guo JJ Tang N Yang HL at al | 2010 | J Bone Joint Surg(Br)2010，92，7： | 1 |
| 16 | Apelin and its receptor APJ in cardiovascular diseases 显示文摘 | YU X H TANG Z B LIU L J et at | 2014 | Clin Chim Acta2014，428，： | 1 |
| 17 | Novel application of vacuumassisted closure technique to the treamtent of sternotomy wound infection显示文摘 | Tang AT Ohri SK Haw MP | 2000 | Eur J Cardiothorac Surg2000，17，4： | 1 |
| 18 | Cerebral cavernous malforma- tions arise from endothelial gain of MEKK3-KLF2/4 signalling显示文摘 | Zhou Z Tang AT Wong WY | 2016 | Nature2016，532，7597： | 1 |
| 19 | Streptococcal toxic shock syndrome caused by Streptococcus suis serotype 2显示文摘 | Tang J Wang C Feng Y et at | 2006 | PLoS Med2006，3，5： | 1 |
| 20 | Post-transplant small cell carcinoma arising in the native kidney of renal transplant recipient显示文摘 | Tang W Ma L Hou X et at | 2009 | Indi- an J Urol2009，25，2： | 1 |
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