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| 1 | Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation显示文摘AIM To explore the expression of perform andgranzyme B genes mRNA to judge the effect ofimmunosuppression in acute rejection of livertransplantation.METHODS The expression of perform andgranzyme B genes mRNA was examined byreverse transcriptase-polymerase chain reaction(RT--PCR) in hamster to rat liver grafts under theimmunosuppression of cyclosporine or/andsplenectomy. Histological findings were studiedcomparatively.RESULTS Cyclosporine could obviouslydecrease the cellular infiltration, and completelyrepress the expression of mRNA for perform andgranzyme B, but could not change severehepatocyte necrosis and hemorrhage.SPlenectomy could significantly lightenhepatocyte necrosis, and completely eliminatehemorrhage, but not atfect the cellularinfiltration and the expression of perform andgranzyme B genes mRNA. Cyclosporine orsplenectomy alone could not prolong theSurvival time, however, their combination couldcompletely repress the rejection of liver grafts.The survival time of animals were significantlyprolonged (37.1 days ). The architecture ofhepatic lobules was preserved. There was slightcellular infiltration in the portal tracts and noexpression of perform and granzyme B genesmRNA could be seen in three weeks aftertransplantation.CONCLUSION Perform and granzyme B genesare valuable in judging the effect ofimmunosuppression in liver transplantation. | Zhang SG Wu MC Tan JW Chen H Yang JM Qian QJ | 1999 | World Journal of Gastroenterology1999，5，3： | 15 |
| 2 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 3 | N ADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Peri- cytes in Early Diabetic Retinopathy 显示文摘 | Mustapha N M Tan' JM Kohner EM | 2010 | J Ophthalmol2010，2010，74： | 1 |
| 4 | Interleukin-1 induce tubular epithelia-myofibroblast transdifferentiation throngh a transforming growth factor-betal dependent mechanism in vitro显示文摘 | Tan JM Huarg XR Ng YY | 2001 | Am J Kidney Dis2001，37，7： | 1 |
| 5 | The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes 显示文摘 | Tan GD Fielding BA Currie JM | 2005 | Diabetologia2005，48，1： | 1 |
| 6 | Incidence and clinical course of thrombocytopenic purpura due to ticlopidine following coronary stenting显示文摘 | Steinhubl SR Tan WA Foody JM | 1999 | JAMA1999，281，9： | 1 |
| 7 | Age, rage and ROS in diabetic nephropathy 显示文摘 | Tan AL Forbes JM Cooper ME | 2007 | Semin Nephrol2007，27，2： | 1 |
| 8 | AGE, RAGE and ROS in diabetic nephropathy显示文摘 | Tan AI Forbes JM Cooper ME | 2007 | Semin Nephrol2007，27，2： | 1 |
| 9 | Clesed versus partially ventilated endotracheal suction in extremely preterm neonates:physiologic consequences显示文摘 | Tan AM Gornez JM Mathews J | 2005 | Intensive Crit Care Nuts2005，21，4： | 1 |
| 10 | Dose-response of remifentanil for tracheal intubation in infants显示文摘 | Crawford MW Hayes J Tan JM | 2005 | Anesth Analg2005，100，： | 1 |
| 11 | Dose - response of remifentanil for tracheal intubation in infants 显示文摘 | Crawford MW Hayes J Tan JM | 2005 | Anesth Analg2005，100，： | 1 |
| 12 | Arterial spin-labeledMR perfusion imaging : clinical applications 显示文摘 | Pollock JM Tan H Kraft RA | 2009 | MagnReson Imaging Clin N Am2009，17，2： | 1 |
| 13 | Inter levkin-1 induce tubular epithelia-myofibroblast transdifferentiation throngh a transforming growth factor-beta 1 dependent machanism in vitro 显示文摘 | Tan JM Huarg XR Ng YY | 2001 | Am J Kidney Dis2001，37，7： | 1 |
| 14 | Generalized epilepsy with febrile seizure plus (GEFS + ) spectrum: Novel de novo mutation of SCN! A detected in a Malaysian patient 显示文摘 | Tan EH Yusoff AA Abdullah JM | 2012 | J Pediatr Neurosci2012，7，2： | 1 |
| 15 | The tissue effects of ultrasound--assisted lipoplasty 显示文摘 | Robinson JB Beran SJ Tan J Howard BK Zocchi ML Rohrich RJ | 1998 | Plast Reconstr Surg1998，102，1： | 1 |
| 16 | Role of the ubiquitin proteasome system in Parkinson's disease显示文摘 | Lim KL Tan JM | 2007 | BMC Biochem2007，，： | 1 |
| 17 | Presence of cellular renin-angiotensin system in chromaffin cells of bovine adrenal medulla 显示文摘 | Wang JM Slembrouck D Tan J | 2002 | Am J Physiol Heart Circ Physiol2002，283，5： | 1 |
| 18 | A practical approach to guide clinicians in the evaluation of male patients with breast masses 显示文摘 | Hines SL Tan W Larson JM | 2008 | Geriatrics2008，63，6： | 1 |
| 19 | Closed versus partially venti- lated endotracheal suction in extremely preterra neonates : physiologic consequences显示文摘 | Tan AM Gomez JM Mathews J | 2005 | Intensive Crit Care Nurs2005，21，4： | 1 |
| 20 | Protein misfolding and aggregation in parkinson' s disease 显示文摘 | Tan JM Wong ES Lira KL | 2009 | Antioxid Redox Signal2009，11，： | 1 |
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