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| 1 | A novel nonviral nanoparticle gene vector: Poly-L-lysine- silica nanoparticles显示文摘DNA delivery is a core technology for gene structure and function research as well as clinical settings. The ability to safely and efficiently targeted transfer foreign DNA into cells is a fundamental goal in biotechnology. With the development of nanobiotechnology, nanoparticle gene vectors brought about new hope to reach the goal. In our research, silica nanoparticles (SiNP) were synthesized first in a microemulsion system polyoxyethylene nonylphenyl ether (OP-10)/cyclohexane/ammonium hydroxide, at the same time the effects of SiNP size and its distribution were elucidated by orthogonal analysis; then poly-L-lysine (PLL) was linked on the surface of SiNP by nanoparticle surface energy and electrostatically binding; lastly a novel complex nanomate-rial-poly-L-lysine-silica nanoparticles (PLL-SiNP) wasprepared. The analysis of plasmid DNA binding and DNase I enzymatic degradation discovered that PLL-SiNP could bind DNA, and protect it against enzymatic degradation. Cell transfection showed that | Shiguo Zhu Hongbin Lu Juanjuan Xiang Ke Tang Bicheng Zhang Ming Zhou Chen Tan Guiyuan Li | 2002 | Chinese Science Bulletin2002，47，8： | 9 |
| 2 | Preparation of continuous alumina gel fibres by aqueous sol–gel process显示文摘 | HONGBIN TAN XIAOLING MA MINGXING FU | 2013 | Bulletin of Materials Science2013，，1： | 1 |
| 3 | Mullite fi-bers prepared from an inorganic sol-gel precursor显示文摘 | Tan Hongbin Ding Yaping Yang Jianfeng | 2010 | Journal of Sol-Gel Science and Technology2010，53，2： | 1 |
| 4 | Mullite fibers prepared from an inorganic sol–gel precursor显示文摘 | Hongbin Tan Yaping Ding Jianfeng Yang | 2010 | Journal of Sol - Gel Science and Technology2010，，2： | 1 |
| 5 | Boundedness of multilinear singular integrals on central Morrey spaces with variable exponents显示文摘We prove the boundedness for a class of multi-sublinear singular integral operators on the product of central Morrey spaces with variable exponents.Based on this result,we obtain the boundedness for the multilinear singular integral operators and two kinds of multilinear singular integral commutators on the above spaces. | Hongbin WANG Jingshi XU Jian TAN | 2020 | Frontiers of Mathematics in China2020，15，5： | 1 |
| 6 | PBWA:A Provenance-Based What-If Analysis Approach for Data Mining Processes显示文摘This paper presents a Provenance-based what-if analysis approach(PBWA) for data mining processes,so decision makers can examine the latest mining result under hypothetical business contexts.It fills the gap that data mining only reveals past status of enterprises with historical data.Provenance information is a kind of metadata of data mining processes.PBWA uses it to identify relevant operation path and intermediate results that is affected by hypothetical business contexts.It refreshes the mining result by partially rerunning the affected portions.Different from previous studies only for relational operations,PBWA can take more general operations into account.Besides,it focuses on the whole mining processes.Experiments demonstrate that when the affected ratio is less than 74% and 87% in different contexts,PBWA can achieve better time performance. | KE Jie DONG Hongbin TAN Chengyu LIANG Yiwen | 2017 | Chinese Journal of Electronics2017，26，5： | 1 |
| 7 | Mid-Holocene Climate Variations Recorded by Palaeolake in Marginal Area of East Asian Monsoon: A Multi-proxy Study显示文摘Traditionally, the mid-Holocene in most parts of China was thought to be warmer with higher precipitation, resulting from a strong Asian summer monsoon. However, some recent researches have proposed a mid-Holocene drought interval of millennial-scale in East Asian monsoon margin areas. Thus whether mid-Holocene was dry or humid remains an open issue. Here, Zhuyeze palaeolake, the terminal lake of the Shiyang River Drainage lying in Asian monsoon marginal areas, was selected for reconstructing the details of climate variations during the Holocene, especially mid-Holocene, on the basis of a sedimentological analysis. Qingtu Lake (QTL) section of 6.92m depth was taken from Zhuyeze palaeolake. Multi-proxy analysis of QTL section, including grain size, carbonate, TOC, C/N and δ13C of organic matter, was used to document regional climatic changes during 9-3 cal ka B.P. The record shows a major environmental change at 9.0-7.8 cal ka B.P., attributed to a climate trend towards warmth and humidity. This event was followed by a typical regional drought event which occurred during 7.8-7.5 cal ka B.P. And a warm and humid climate prevailed from 7.5 to 5.0 cal ka B.P., attributed to the warm/humid Holocene Optimum in this region. After that, the climate gradually became drier. Moreover, comparison of the climate record from this paper with the summer insolation at 30°N indicates that the climate pattern reflecting the Asian monsoon changes was caused by insolation change. | LONG Hao TAN Hongbin WANG Naiang TAN Liangcheng LI Yu | 2007 | Chinese Geographical Science2007，17，4： | 1 |
| 8 | Effect of aluminium sulphate on phase formation and morphology development of mullite whiskers 显示文摘 | TAN Hongbin | 2010 | Clay Minerals2010，45，： | 1 |
| 9 | LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma显示文摘This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma(HCC),further,to explore the effect of LPCAT1 on overall survival(OS)in patients with HCC,and its possible mechanism.Bioinformatics analysis using high throughput RNA-sequencing data from TCGA was utilized to explore the differential expression of LPCAT1 between normal and tumor tissues,and the associations between LPCAT1 expression and clinicopathological parameters.Survival analyses and subgroup survival analyses were utilized to elucidate the effect of LPCAT1 on OS in patients with HCC.Univariate analysis and multivariate analysis were used to investigate the prognostic factors.Potential LPCAT1 related tumor genes were identified by the methodology of differentially expressed genes(DEGs)screening.GO term enrichment analysis,KEGG pathway analysis and the PPI network were used to explore the potential mechanism.LPCAT1 was significantly overexpressed in HCC tumor tissues compared with normal tissues.The LPCAT1 expression was related to tumor grade,ECOG score,AFP and TNM stage,with P values of 0.000,0.000,0.007 and 0.000,respectively.Multivariate analysis demonstrated that LPCAT1 expression was independently associated with OS,with an HR of 1.04(CI:1.01–1.06,P=0.003).The KEGG pathway enrichment analyses showed that overlapped DEGs mainly participate in the cell cycle.Finally,we identified a hub gene,CDK1,which has been reported to act on the cell cycle,consistent with the result of KEGG enrichment analysis.Collectively,these data confirmed LPCAT1 was upregulated in HCC,and was an independent predictor of the prognosis. | Hongbin Zhang Ke Xu Qin Xiang Lijuan Zhao Benxu Tan Ping Ju Xiufu Lan Yi Liu Jian Zhang Zheng Fu Chao Li Jinzhi Wang Jixiang Song Yun Xiao Zhaobo Cheng Yan Wang Shu Zhang Tingxiu Xiang | 2022 | Genes & Diseases2022，9，1： | 0 |
| 10 | Research and Exploration of Future Optical Communication Technology显示文摘With the development and implementation of concepts such as triple play, mobile Internet, Internet of things, cloud computing and intelligent city, China is launching the 'broadband China' national development strategy. This will further accelerate the development of broadband in China, and further promote the related industries, especially optical communications technology, systems and devices and the rapid development of electronic information industry, while promoting the metro and trunk optical transport network construction and expansion, and FTTx optical network construction and bandwidth speed. Under the guidance and promotion of the strategy of 'broadband China', China is entering the new period of broadband construction. The three major telecom operators have further accelerated the construction of FTTx optical access network. In order to meet the needs of this development, ultra-high-speed, large capacity, ultra-long distance optical transport network technology research will accelerate;fi ber access technology will be the next generation of broadband optical access network NG PON technology development and evolution. This paper mainly discusses the development history and development status of optical fi ber communication technology, the technology used and its future development trend. | Hongbin Gu Jungui Xu Kaitao Tan Yejun Xie | 2019 | Insight-Information2019，1，1： | 0 |
| 11 | Research and Exploration of Future Optical Communication Technology显示文摘With the development and implementation of concepts such as triple play, mobile Internet, Internet of things, cloud computing and intelligent city, China is launching the 'broadband China' national development strategy. This will further accelerate the development of broadband in China, and further promote the related industries, especially optical communications technology, systems and devices and the rapid development of electronic information industry, while promoting the metro and trunk optical transport network construction and expansion, and FTTx optical network construction and bandwidth speed. Under the guidance and promotion of the strategy of 'broadband China', China is entering the new period of broadband construction. The three major telecom operators have further accelerated the construction of FTTx optical access network. In order to meet the needs of this development, ultra-high-speed, large capacity, ultra-long distance optical transport network technology research will accelerate;fi ber access technology will be the next generation of broadband optical access network NG PON technology development and evolution. This paper mainly discusses the development history and development status of optical fi ber communication technology, the technology used and its future development trend. | Hongbin Gu Jungui Xu Kaitao Tan Yejun Xie | 2018 | Computer System Networking and Telecommunications2018，1，1： | 0 |
| 12 | Preparation of Long Alumina Fibers in Aqueous Solution Using Oxalic Acid and Aluminum Nitrate显示文摘Long alumina fibers with 60 cm in length were prepared by sol-gel method. The spinning sol was obtained by mixing aluminum nitrate, oxalic acid, and polyvinylpyrrolidone with a mass ratio of 10∶3∶2. Fourier transform infrared (FTIR) spectra, X-ray diffraction (XRD), and scanning electron microscopy (SEM) were used to characterize the properties of the gel and ceramic fibers. The fibers with uniform diameter and smooth surface were obtained by sintering at 1 200 ℃ for 1 h, and their main phase was indentified as α-Al2O3. | GUO Congsheng FU Mingxing TAN Hongbin | 2011 | China's Refractories2011，20，2： | 0 |
| 13 | A Totally Depleted Au-silicon Surface-barrier Charged Particle Telescope System显示文摘In nuclear physics experiments, the depleted Au-silicon surface-barrier charged particle telescope△E-E system detectors in various thickness are the important tools, which are used not only to measure the energies of particles, and also identify the various kinds of particles. When the charged particles pass | Wang Zhusheng, Tan Jilian, Xiao Guoqing, Li Zhankui, Bao Zhiqin Lu Ziwei, Li Longcan, Zhang Ling and Zhang Hongbin | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 14 | A GaAs Nuclear Radiation Detector显示文摘The nuclear detectors of semiconductor germanium and silicon are widely used in nuclear radiation detect, which have a small volume, a short rise time, and a high energy resolution. But the germanium and silicon materials have the narrow forbidden energy gap (Ge:Eg= 0. 665 eV, Si:Eg=1.12 eV) and atomic number (Ge:Z=32, Si:Z=14). Therefore, they have the limitation in applications. The gallium arsenic material has the preponderance of wide forbidden energy gap(Eg=1.45 eV and high atomic number | Wang Zhusheng, Xiao Guoqing, Tan Jilian, Li Zhankui, Lu Ziwei Bao Zhiqin, Zhang Ling, Li Longcan and Zhang Hongbin | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 15 | Identification of positive cofactor 4 as a diagnostic and prognostic biomarker associated with immune infiltration in hepatocellular carcinoma显示文摘Background and aims:Human positive cofactor 4(PC4)is associated with the development and therapeutic resistance of several malignancies.However,the role of PC4 in hepatocellular carcinoma(HCC)remains obscure.Methods:The expression status of PC4 was explored in Gene Expression Omnibus and The Cancer Genome Atlas datasets.Subsequently,the prognostic and diagnostic significance of PC4 in HCC patients was analyzed.Functional enrichment analyses were conducted to explore biological functions and potential mechanisms.The CIBERSORT algorithm was used for immune infiltration analysis.The risk signature was constructed by LASSO-Cox regression and was validated with the International Cancer Genome Consortium dataset.Quantitative real-time polymerase chain reaction was used to verify the expression levels of all genes.Tumor Immune Dysfunction and Exclusion analysis evaluated immunotherapy response.Finally,using online databases,PC4-related competing endogenous RNA networks were constructed.Results:PC4 levels were significantly upregulated in HCC and positively correlated with the pathological grade and clinical stage.The PC4-high expression group showed worse prognosis.In addition,PC4 could distinguish between tumor and normal tissues with an area under the curve of 0.965.The PC4 level was associated with immune checkpoints and immune cell infiltration.In the training and validation sets,the eight-gene risk signature strongly correlated with HCC patient prognosis.Tumor Immune Dysfunction and Exclusion analysis showed that patients in both the PC4-low and low-risk groups were more likely to benefit from immunotherapy.Finally,an lncRNA/microRNA-101-3p/PC4 network was constructed.Conclusion:We confirmed PC4 as a diagnostic and prognostic biomarker in HCC patients.We also developed and validated an eight-gene risk signature,which will help in clinical decision-making.The competing endogenous RNA network could help explore the regulatory mechanisms of PC4 in HCC. | Liangliang Bai Guan Liu Gang Dou Xiaojun He Chenyu Gong Hongbin Zhang Kai Tan Xilin Du | 2023 | iLIVER2023，2，4： | 0 |
| 16 | 多块巨大柿子粪石引起的胃出口梗阻病例显示文摘A phytobezoar is a bezoar or trapped mass in the gastrointestinal system that consists of indigestible plant material such as fibers,skins and seeds.A persimmon phytobezoar(considered to be harder than other types of phytobezoars)is formed after frequent consumption of persimmons.The complication of gastrointestinal tract obstruction from bezoars was found to exist in the intestines but was rarely reported in the gastric tract because of its flexible volume.Here we present a 57-yearold man with persimmon phytobezoars,which ultimately led to gastric outlet obstruction. | Fengbo Tan Hongbin Mo Xiao He Haiping Pei | 2019 | Gastroenterology Report2019，7，1： | 0 |
| 17 | Effects of Buffer Layer on Hetero-Epi-Growth of SiCGe on 6H-SiC显示文摘Growth of SiCGe ternary alloy on 6H-SiC in a conventional hot-wall CVD system was initially studied. SiH4, GeH4 and C3H8 were employed as silicon, germanium and carbon source, respectively, while H2 was employed as the carrier gas. To reduce the heavy lattice mismatch between the film and the substrate, a 3C-SiC buffer layer was inserted between them in a CVD process. Optimizing the growth conditions was discussed. The samples were measured by means of SEM, SAXRD (Small Angle X-Ray Diffraction). It is shown that use of the 3C-SiC buffer layer is an effective way to improve the quality of the ternary alloy. | Tan Changxing Chen Zhiming Pu Hongbin Lu Gang Li Lianbi | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
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