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| 1 | Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration显示文摘The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property.Bone marrow stem cells(BMSCs)derived exosomes(Exos)contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions.Herein,we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation.BMSC-derived Exos were reversibly incorporated on tannic acid(TA)modified sulfonated polyetheretherketone(SPEEK)via the strong interaction of TA with biomacromolecules.The slowly released Exos from SPEEK can be phagocytosed by co-cultured cells,which could efficiently improve the biocompatibilities of SPEEK.In vitro results showed the Exos loaded SPEEK promoted macrophage M2 polarization via the NF-κB pathway to enhance BMSCs osteogenic differentiation.Further in vivo rat air-pouch model and rat femoral drilling model assessment of Exos loaded SPEEK revealed efficient macrophage M2 polarization,desirable new bone formation,and satisfactory osseointegration.Thus,BMSC-derived Exos-functionalized implant exerted osteoimmunomodulation effect to promote osteogenesis. | Lei Fan Pengfei Guan Cairong Xiao Huiquan Wen Qiyou Wang Can Liu Yian Luo Limin Ma Guoxin Tan Peng Yu Lei Zhou Chengyun Ning | 2021 | Bioactive Materials2021，6，9： | 11 |
| 2 | Corrosion mechanism of micro-arc oxidation treated biocompatible AZ31 magnesium alloy in simulated body fluid显示文摘The rapid degradation of magnesium(Mg) based alloys has prevented their further use in orthopedic trauma fixation and vascular intervention,and therefore it is essential to investigate the corrosion mechanism for improving the corrosion resistance of these alloys. In this work, the effect of applied voltage on the surface morphology and the corrosion behavior of micro-arc oxidation(MAO) with different voltages were carried out to obtain biocompatible ceramic coatings on AZ31 Mg alloy. The effects of applied voltage on the surface morphology and the corrosion behavior of MAO samples in the simulated body fluid(SBF) were studied systematically. Scanning electron microscope(SEM) and X-ray diffractometer(XRD)were employed to characterize the morphologies and phase compositions of coating before and after corrosion. The results showed that corrosion resistance of the MAO coating obtained at 250 V was better than the others in SBF. The dense layer of MAO coating and the corrosion precipitation were the key factors for corrosion behavior. The corrosion of precipitation Mg(OH)2and the calcium phosphate(Ca–P) minerals on the surface of MAO coatings could enhance their corrosion resistance effectively. In addition, the mechanism of MAO coated Mg alloys was proposed. | Ying Li Fang Lu Honglong Li Wenjun Zhu Haobo Pan Guoxin Tan Yonghua Lao Chengyun Ning Guoxin Ni | 2014 | Progress in Natural Science:Materials International2014，24，5： | 7 |
| 3 | Promoting Bone Mesenchymal Stem Cells and Inhibiting Bacterial Adhesion of Acid-Etched Nanostructured Titanium by Ultraviolet Functionalization显示文摘Titanium(Ti) and its alloys are used extensively in orthopedic implants because of their excellent biocompatibility,mechanical properties and corrosion resistance. However,titanium-based implant materials face many severe complications,such as implant loosening due to poor osseointegration and bacterial infections,which may lead to implant failure. Hence,preparing a biomaterial surface,which enhances the interactions with host cells and inhibits bacterial adhesion,may be an optimal strategy to reduce the incidence of implant failure. This study aims to improve osseointegration and confer antibacterial properties on Ti through a combination of two surface modifications including nanostructuring generated by acid etching and ultraviolet(UV) light treatment.Our results showed that without UV treatment,the acid etching treatment of Ti surface was effective at both improving the adhesion of bone mesenchymal stem cells(BMSCs) and increasing bacterial adhesion. A further UV treatment of the acid-etched surface however,not only significantly improved the cell adhesion but also inhibited bacterial adhesion. The acid-etched nanostructured titanium with UV treatment also showed a significant enhancement on cell proliferation,alkaline phosphatase(ALP) activity and mineralization. These results suggest that such nanostructured materials with UV treatment can be expected to have a good potential in orthopedic applications. | Guobo Lan Mei Li Ying Tan Lihua Li Xiaoming Yang Limin Ma Qingshui Yin Hong Xia Yu Zhang Guoxin Tan Chengyun Ning | 2015 | Journal of Materials Science & Technology2015，31，2： | 7 |
| 4 | A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform显示文摘The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier(NLC) drug delivery platform. An ophthalmic antiinflammatory drug, baicalin(BN) was chosen as the model drug. BN –NLC was prepared using melt-emulsification combined with ultra-sonication technique. Additionally, a dual pH-and thermo-sensitive hydrogel composed of carboxymethyl chitosan(CMCS) and poloxamer 407(F127) was fabricated by a cross-linking reaction with a nontoxic crosslinker genipin(GP). GP-CMCS/F127 hydrogel was characterized by FTIR, NMR, XRD and SEM. The swelling studies showed GP-CMCS/F127 hydrogel was both pH-and thermo-sensitive. The results of in vitro release suggested BN –NLC gel can prolong the release of baicalin comparing with BN eye drops and BN –NLC. Ex vivo cornea permeation study was evaluated using Franz diffusion cells. The apparent permeability coefficient(Papp) of BN –NLC gel was much higher(4.46-fold) than that of BN eye drops. Through the determination of corneal hydration levels, BN –NLC gel was confirmed that had no significant irritation to cornea. Ex vivo precorneal retention experiments were carried out by a flow-through approach. The results indicated that the NLC-based hydrogel can prolong precorneal residence time. In conclusion, the hybrid NLCbased hydrogel has a promising potential for application in ocular drug delivery. | Yibin Yu Ruoxi Feng Jinyu Li Yuanyuan Wang Yiming Song Guoxin Tan Dandan Liu Wei Liu Xinggang Yang Hao Pan Sanming Li | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 3 |
| 5 | Room thermal load prediction based on analytic hierarchy process and back-propagation neural networks显示文摘Accurate prediction of the heat load is the basic premise of intelligent regulation of the heating system,which helps to realize effective management of heating,ventilation,air conditioning system.For the problem that the weight of each influencing factor is not taken into account in the current heat load prediction and is not highly targeted,this article deeply explores the influence of different factors on the room heat load,and we propose a method to calculate room heat load prediction based on the combination of analytic hierarchy process(AHP)and back-propagation(BP)neural network.Firstly,eight environmental factors affecting the heat load are selected as prediction inputs through parametric analysis,and then the weights of each input are determined by AHP and normalize the prediction data by combining expert opinions,and finally do one-to-one training the quantified score and the room heat load to predict the future heat load by BP neural network.The simulation tests show that the mean absolute relative error(MARE)of the proposed prediction method is 5.40%.This article also verifies the influence of different expert opinions on the stability of the model.The results show that the proposed method can guarantee higher prediction accuracy and stability. | Xin Tan Zhenjing Zhu Guoxin Sun Linfeng Wu | 2022 | Building Simulation2022，15，11： | 2 |
| 6 | An injectable,self-healing,electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury显示文摘Injectable biomaterial-based treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury(SCI)by bridging cavity spaces.However,there are limited reports of injectable,electroconductive hydrogels with self-healing properties being employed for the treatment of traumatic SCI.Hence,a natural extracellular matrix(ECM)biopolymer(chondroitin sulphate and gelatin)-based hydrogel containing polypyrrole,which imparted electroconductive properties,is developed for traumatic SCI repair.The resulting hydrogels showed mechanical(~928 Pa)and conductive properties(4.49 mS/cm)similar to natural spinal cord tissues.Moreover,the hydrogels exhibited shear-thinning and self-healing abilities,which allows it to be effectively injected into the injury site and to fill the lesion cavity to accelerate the tissue repair of traumatic SCI.In vitro,electroconductive ECM hydrogels promoted neuronal differentiation,enhanced axon outgrowth,and inhibited astrocyte differentiation.The electroconductive ECM hydrogel activated endogenous neural stem cell neurogenesis in vivo(n=6),and induced myelinated axon regeneration into the lesion site via activation of the PI3K/AKT and MEK/ERK pathways,thereby achieving significant locomotor function restoration in rats with spinal cord injury(p<0.001,compared to SCI group).Overall,the injectable self-healing electroconductive ECM-based hydrogels developed in this study are ideal biomaterials for treatment of traumatic SCI. | Yian Luo Lei Fan Can Liu Huiquan Wen Shihuan Wang Pengfei Guan Dafu Chen Chengyun Ning Lei Zhou Guoxin Tan | 2022 | Bioactive Materials2022，7，1： | 2 |
| 7 | Controllable Protein Adsorption and Bacterial Adhesion on Polypyrrole Nanocone Arrays显示文摘In this research, polypyrrole nanocone arrays doped with β-Naphthalene sulphonic acid(PPy-NSA) were built. This film was expected to control protein adsorption and bacterial adhesion by potential-induced reversibly redox. The scanning Kelvin probe microscopy(SKPM) and surface contact angles(SCA) tests suggested that the surface potential and wettability of PPy-NSA nanocone arrays could be controlled by simply controlling its redox property via applying potential. The controllable surface potential and wettability in return controlled the adsorption of protein and adhesion of bacteria. The proposed material might find application in the preparation of smart biomaterial surfaces that can regulate proteins and bacterial adhesion by a simple potential switching. | Zhengnan Zhou Weiping Li Tianrui He Peng Yu Guoxin Tan Chengyun Ning | 2016 | Journal of Materials Science & Technology2016，32，9： | 2 |
| 8 | Global estimation of crop productivity and the impacts of global wanning by GIS and EPIC integration显示文摘 | Guoxin Tan | 2003 | 75(4):409 - 4162003，75，4： | 1 |
| 9 | Influence of water states in hydrogels on the transmissibility and permeability of oxygen in contact lens materials显示文摘 | Yingjun Wang Guoxin Tan Shujiang Zhang | 2008 | Applied surface science2008，255，： | 1 |
| 10 | Synthe-sis and characterization of injectable photocrosslinkingpoly(ethylene glycol)diacrylate based hydrogels显示文摘 | TAN Guoxin WANG Yingjun LI Jun | 2008 | Polymer Bulletin2008，61，1： | 1 |
| 11 | Global estimation of crop productivity and the impacts of global warming by GIS and EPIC integration显示文摘 | Tan Guoxin Shibasaki R | 2003 | Ecological Modelling2003，168，： | 1 |
| 12 | Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation显示文摘To improve the osteointegration property of biomedical titanium,nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and pyrrole.The highly binding affinity of Ca2t to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral ions.The results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body fluid.The PPy/PDA nanowires coating could be applied to promote the osteointegration of titanium implant. | Zhengao Wang Jinquan Zeng Guoxin Tan Jingwen Liao Lei Zhou Junqi Chen Peng Yu Qiyou Wang Chengyun Ning | 2018 | Bioactive Materials2018，3，1： | 1 |
| 13 | Increased levels of SLP-2 correlate with poor prognosis in gastric cancer显示文摘 | Dongning Liu Lei Zhang Zhiyong Shen Fei Tan Yanfeng Hu Jiang Yu Guoxin Li | 2013 | Gastric Cancer2013，，4： | 1 |
| 14 | Effect of Amino-,Methyl- and Epoxy-Silane Coupling as a Molecular Bridge for Formatting a Biomimetic Hydroxyapatite Coating on Titanium by Electrochemical Deposition显示文摘The objective of this study was to determine the role of functional groups of silane coupling on bioactive titanium(Ti) surface by electrochemical deposition, and calcium phosphate(CaP) coating, as well as bone cell adhesion and proliferation. Methyl group(—CH_3), amino group(—NH_2), and epoxy group(—glyph name—C(O)C) were introduced onto the bioactive Ti surface using self-assembled monolayers(SAMs)with different silane coupling agents as molecular bridges. The effect of the surface functional groups on the growth features of the CaP crystals was analyzed(including chemical compositions, element content,minerals morphology and crystal structure etc.). CH_3- terminated SAMs showed a hydrophobic surface and others were hydrophilic by contact angle measurement; NH_2-terminated SAMs showed a positive charge and others were negatively charged using zeta-potential measurement. Scanning electron microscopy results confirmed that flower-like structure coatings consisting of various pinpoint-like crystals were formatted by different functional groups of silane coupling, and the CaP coatings were multicrystalline consisting of hydroxyapatite(HA) and precursors. Ca P coating of CH_3- terminated SAMs exhibited more excellent crystallization property as compared to coatings of —NH_2 and —C(O)C groups. In vitro MC3T3-E1 cells adhesion and proliferation were performed. The results showed that CaP coatings on silane coupling functionalized surfaces supported cell adhesion and proliferation. Thus, these functional groups of silane coupling on Ti can form homogeneous and oriented nano-CaP coatings and provide a more biocompatible surface for bone regeneration and biomedical applications. | Guoxin Tan Kongyou Ouyang Hang Wang Lei Zhou Xiaolan Wang Yan Liu Lan Zhang Chengyun Ning | 2016 | Journal of Materials Science & Technology2016，32，9： | 1 |
| 15 | Wireless electrical stimulation at the nanoscale interface induces tumor vascular normalization显示文摘Pathological angiogenesis frequently occurs in tumor tissue, limiting the efficiency of chemotherapeutic drug delivery and accelerating tumor progression. However, traditional vascular normalization strategies are not fully effective and limited by the development of resistance. Herein, inspired by the intervention of endogenous bioelectricity in vessel formation, we propose a wireless electrical stimulation therapeutic strategy, capable of breaking bioelectric homeostasis within cells, to achieve tumor vascular normalization. Polarized barium titanate nanoparticles with high mechano-electrical conversion performance were developed, which could generate pulsed open-circuit voltage under low-intensity pulsed ultrasound. We demonstrated that wireless electrical stimulation significantly inhibited endothelial cell migration and differentiation in vitro. Interestingly, we found that the angiogenesis-related eNOS/NO pathway was inhibited, which could be attributed to the destruction of the intracellular calcium ion gradient by wireless electrical stimulation. In vivo tumor-bearing mouse model indicated that wireless electrical stimulation normalized tumor vasculature by optimizing vascular structure, enhancing blood perfusion, reducing vascular leakage, and restoring local oxygenation. Ultimately, the anti-tumor efficacy of combination treatment was 1.8 times that of the single chemotherapeutic drug doxorubicin group. This work provides a wireless electrical stimulation strategy based on the mechano-electrical conversion performance of piezoelectric nanoparticles, which is expected to achieve safe and effective clinical adjuvant treatment of malignant tumors. | Changhao Li Cairong Xiao Lizhen Zhan Zhekun Zhang Jun Xing Jinxia Zhai Zhengnan Zhou Guoxin Tan Jinhua Piao Yahong Zhou Suijian Qi Zhengao Wang Peng Yu Chengyun Ning | 2022 | Bioactive Materials2022，7，12： | 1 |
| 16 | Self-curling electroconductive nerve dressing for enhancing peripheral nerve regeneration in diabetic rats显示文摘Conductive scaffolds have been shown to exert a therapeutic effect on patients suffering from peripheral nerve injuries(PNIs).However,conventional conductive conduits are made of rigid structures and have limited applications for impaired diabetic patients due to their mechanical mismatch with neural tissues and poor plasticity.We propose the development of biocompatible electroconductive hydrogels(ECHs)that are identical to a surgical dressing in this study.Based on excellent adhesive and self-healing properties,the thin film-like dressing can be easily attached to the injured nerve fibers,automatically warps a tubular structure without requiring any invasive techniques.The ECH offers an intimate and stable electrical bridge coupling with the electrogenic nerve tissues.The in vitro experiments indicated that the ECH promoted the migration and adhesion of the Schwann cells.Furthermore,the ECH facilitated axonal regeneration and remyelination in vitro and in vivo through the MEK/ERK pathway,thus preventing muscle denervation atrophy while retaining functional recovery.The results of this study are likely to facilitate the development of non-invasive treatment techniques for PNIs in diabetic patients utilizing electroconductive hydrogels. | Can Liu Lei Fan Zhenming Tian Huiquan Wen Lei Zhou Pengfei Guan Yian Luo Chuncheung Chan Guoxin Tan Chengyun Ning Limin Rong Bin Liu | 2021 | Bioactive Materials2021，6，11： | 1 |
| 17 | Global estimation of crop productivity and the impacts of global warming by GIS and EPIC integration 显示文摘 | Tan Guoxin Shibasaki Ryosuke | 2003 | Ecological Modelling2003，168，： | 1 |
| 18 | Global estimation of crop productivity and the impacts of global warming by GIS and EPIC integration显示文摘 | Guoxin Tan Ryosuke S | 2003 | Ecological Modelling2003，168，： | 1 |
| 19 | Global estimation of crop productivity and the impacts of global warming by GIS and EPIC integration显示文摘 | Tan Guoxin Shibasaki R | 2003 | Ecological Modeling2003，168，： | 1 |
| 20 | Global estimation of crop productivity and the impacts of globalwarming by GIS and EPIC integration 显示文摘 | Guoxin Tan Ryosuke Shibasaki | 2003 | Ecological Modelling2003，168，： | 1 |
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