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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 3 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 4 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 5 | Seeing is believing:anti-PD-1/PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy显示文摘Structural immunology,focusing on structures of host immune related molecules,enables the immunologists to see what the molecules look like,and more importantly,how they work together.Antibody-based PD-1/PD-L1 blockade therapy has achieved brilliant successes in clinical applications.The recent breakthrough of the complex structures of checkpoint blockade antibodies with their counterparts,pembrolizumab with PD-1 and avelumab with PD-L1,have made it clear how these monoclonal antibodies compete the binding of PD-1/PD-L1 and function to blockade the receptor-ligand interaction.Herein,we summarize the structural findings of these two reports and look into the future for how this information would facilitate the development of more efficient PD-1/PD-L1 targeting antibodies,small molecule drugs,and other protein or non-protein inhibitors. | Shuguang Tan Catherine W-H Zhang George F Gao | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 8 |
| 6 | Cultivation-dependent and cultivation-independent characterization of the microbial community in acid mine drainage associated with acidic Pb/ Zn mine tailings at Lechang, Guangdong, China显示文摘 | Tan GL Shu WS Hallberg KB Li F Lan CY Huang LN | 2007 | 中国生物学文摘2007，21，7： | 3 |
| 7 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 8 | Activity of β-C2S under different sintering conditions 显示文摘 | Lu Z Y Tan K F | 1997 | Cement and Concrete Research1997，27，7： | 1 |
| 9 | Identification and occurrence of tetrad-forming Alphaproteobacteria in anaerobic-aerobic activated sludge processes 显示文摘 | WONG M T TAN F M NG W J | 2004 | Microbiology2004，150，： | 1 |
| 10 | A Novel Strategy to Fabricate γ-Fe2O3-MWCNTs Hybrids with Selectively Ferromagnetic or Superparamagnetic Properties 显示文摘 | Fan X B Tan F Y Zhang G L | 2007 | Mater Sci & Eng A2007，45，： | 1 |
| 11 | Rutting prediction of asphah pave ment layer using C -φ model显示文摘 | Fwa T F Tan S A Zhu L Y | 2004 | Journal of Transportation En gineering ASCE2004，130，5： | 1 |
| 12 | Fuzzy multiobjective approach for minimization of injection molding defects显示文摘 | TAN K H YUEN M M F | 2000 | Polymer Engineering and Science2000，40，4： | 1 |
| 13 | The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE)显示文摘 | TAN E M COHEN A S FRIES J F | 1982 | Arthritis Rheum1982，25，11： | 1 |
| 14 | Genetic bases of appearance quality of rice grains in Shanyou 63, an elite rice hybrid显示文摘 | Tan Y F Li J X Yu S B et a1 | 2000 | Theor Appl Genet2000，101，56： | 1 |
| 15 | High-strength reinforced concrete deep and short beams:shear design equations in North America and UK practice显示文摘 | Tan K H Dong F K Weng L W | 1998 | ACI Structural Journal1998，95，3： | 1 |
| 16 | Modeling of accessory element distribution in copper smehing process 显示文摘 | Tan P F Zhang C F | 1997 | Scandinavian Journal of Metallurgy1997，26，3： | 1 |
| 17 | Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation显示文摘 | Jiang X Yang F Tan H | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 18 | Cu-A1 IMC micro strueture study in Cu wire bonding with TEM显示文摘 | Y Y Tan F K Yong | 2010 | IEEE2010，，： | 1 |
| 19 | Online consumer trust: a multi- dimensional model 显示文摘 | Tan F B Sutherland P | 2004 | Journal of Electronic Commerce in Organizations2004，2，3： | 1 |
| 20 | 16S ribosomal DNA analysis and char-acterization of lactic acid bacteria associated with traditional Tibetan Qula cheese made from yak milk显示文摘 | TAN Z F PANG H L DUAN Y H | 2010 | Animal Science Journal2010，81，： | 1 |
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