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20篇 您的检索式:作者名="Tam AS"
    题名 作者 年代 出处 被引量
1A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis.Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke 2005World Journal of Gastroenterology2005,11,7:15
2High frequency and heterogeneous distribution of p53 mutation in aflatoxin B1-induced mouse lung tumours显示文摘 Foley JF Devereux JW 1999Cancer Res1999,59,15:1
3Retinal ganglion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43显示文摘KrugerK Tam AS Lu C 1998J Neurosis1998,18,15:1
4Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)显示文摘Tam LC Kiang AS Kennan A 2008Hum Mol Genet2008,17,14:1
5An experimental platform for systemic drug delivery tothe retina显示文摘Campbell M ’ Nguyen AH Kiang AS Tam L Gobbo OL KerskensC 2009Proc NaU Acad Sci U S2009,106,17:1
6High frequency and heterogeneous distribution of p53 mutations in aflatoxin B1-induced mouse lung tumors显示文摘 Foley JF Devereux TR 1999Cancer Res1999,59,15:1
7High frequency and heterogeneous distribution of P53 mutations in ariatoxin B1-induced mouse lung tumors 显示文摘Tam AS Foley JF Devereux TR 1999Cancer Res1999,59,15:1
8High frequence and heterogeneous distribution of aflatoxin Bl -induced mouse lung tumors 显示文摘Tam AS Foley JF Deverux TR 1999Cancer Res1999,59,15:1
9Retinal gan- glion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43 显示文摘Kruger K Tam AS Lu C 1998J Neurosci1998,18,:1
10Bargaining sets and the core in partitioning games显示文摘Tam′as Solymosi 2008Central European J of Operations Research2008,10,16:1
11The 1982 revised criteria for the classification of systemic lupus erythematosus显示文摘Tam EM Cohen AS Fries JF 1982Arthritis Rheum1982,25,:1
12The 1982 revised criteria for the classification of systemic lupus erythematosus 显示文摘Tam EM Cohen AS Fries JF 1982Arthritis Rheum1982,25,:1
13High-quality binary protein interaction map of the yeast interactome network显示文摘Yu HY Braun P Yildirim MA Lemmens I Venkatesan K Sahalie J Hirozane-Kishikawa T Gebreab F Li N Simonis N Hao T Rual JF Dricot A Vazquez A Murray RR Simon C Tardivo L Tam S Svrzikapa N Fan CY de Smet AS Motyl A Hudson ME Park J Xin XF Cusick ME Moore T Boo 0,,5898:1
14Role of reactive oxygen speciesgenerating enzymes and hydrogen peroxide during cadmium,mercury and osmotic stresses in barley root tip 显示文摘Tam as L Mistrik I Huttova J 2010Planta2010,231,2:1
15High frequence and heterogeneous distribution of aflatoxin BI - induced mouse lung tumors显示文摘Tam AS Foley JF Deverux TR 1999Cancer Res1999,59,15:1
16High frequence and heterogeneous distribution of aflatoxin Bl - induced mouse lung tumors显示文摘Tam AS Foley JF Deverux TR 1999Cancer Res1999,59,15:1
17Retinal ganglion cell axonprogression from the optic chiasm to initiate optic tractdevelopment requires cell autonomous function ofGAP-43显示文摘Kruger K Tam AS Lu C 1998J Neurosci1998,18,15:1
18The 1982 revised criteria for the classification of systemic lupus erythematosus(SLE)显示文摘 COHEN AS Fries JF 1982Arthritis Rheum1982,25,:1
19Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced mouse lung tumors显示文摘Tam AS Devereux TR Patel AC 2003Carcinogenesis2003,24,1:1
20Corrosion-protection properties of water- borne paint coatings as studied by electrochemical im- pedance spectroscopy and gravimetry显示文摘Gabriella Lendvay-Gy'' orik Tam' as Paikossy Br ela Lengyel 2006Progress in Organic Coatings2006,56,4:1
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