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| 1 | Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence显示文摘AIM: To study the correlation between the patterns of subcellular expression of p16 and CDK4 in colorectal epithelia in the normal-adenoma-carcinoma sequence. METHODS: Paraffin sections of 43 cases of normal colorectal epithelia and corresponding adenomas as well as carcinomas were analysed immunocytochemically for subcellular expression of p16 and CDK4 proteins. RESULTS: Most carcinomas showed more cytoplasmic overexpression for p16 and CDK4 than the adenomas from which they arised or the adjacent normal mucosa. Most normal or non-neoplastic epithelia showed more p16 and CDK4 expression in the nucleus than their adjacent adenomas and carcinomas. There was a significant difference between the subcellular expression pattern of p16 and CDK4 in normal-adenoma-carcinoma sequence epithelia (P < 0.001). Neither p16 nor CDK4 subcellular patterns correlated with histological grade or Dukes’ stage. CONCLUSION: Interaction of expression of p16 and CDK4 plays an important role in the Rb/p16 pathway. Overexpression of p16 and CDK4 in the cytoplasm, as well as loss expression of p16 in the nucleus might be important in the evolution of colorectal carcinoma from adenoma and, of adenoma from normal epithelia. | PO Zhao Xin Mao Ian C Talbot | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 2 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 3 | FM-dyes as experimental probes for dissecting vesicle trafficking in living plant cells 显示文摘 | Bolte S Talbot C Boutte Y | 2004 | Journal of Microscopy2004，214，2： | 1 |
| 4 | Pressure and Velocity Distribution for Air Flow Through Fruits Packed in Shipping Containers Using Porous Media Flow Analysis 显示文摘 | Talbot M T Oliver C C Gaffney P E | 1990 | ASHARE Transactions1990，9，： | 1 |
| 5 | Uptake of Streptococcus pneumoniae by respiratory epithelial eells 显示文摘 | TALBOT U M PATON A W PATON J C | 1996 | Infeet Immun1996，64，： | 1 |
| 6 | A phase Ⅱ trial of docetaxel and estramustine in patients with refractory metastatic breast carcinoma 显示文摘 | TIERSTEN AD NELSEN C TALBOT SL | 2003 | Cancer2003，97，3： | 1 |
| 7 | A phase 2 trial of docetaxel and estramustine in patients with refractory metastatic breast carcinoma显示文摘 | Tiersten AD Nelsen C Talbot SL | 2003 | Cancer2003，97，3： | 1 |
| 8 | External shapes,strain rates and dyna- mics of salt structure 显示文摘 | Jackson M P A Talbot C J | 1986 | GSA Bulletin1986，97，3： | 1 |
| 9 | A Magnaporthe grisea cyclophilin acts as a virulence determinant during plant infection显示文摘 | VIAUD M C BALHDERE P V TALBOT N J | 2002 | The Plant Cell2002，14，： | 1 |
| 10 | Surface microstructure and scaling resistance of concrete显示文摘 | Talbot C Marchand J | 1996 | Cement and Concrete Research1996，26，10： | 1 |
| 11 | Uncoupling protein and ATP/ADP carrier increase mitochondrial proton condu-ctance after cold adaptation of king penguins 显示文摘 | Talbot D A Duchamp C Rey B | 2004 | J Physiol2004，558，12： | 1 |
| 12 | Epithelial-mesenchymal transition,the tumor microenvironment,and metastatic behavior of epithelial malignancies显示文摘 | Talbot L J Bhattacharya S D Kuo P C | | 0，，02： | 1 |
| 13 | Bacterial community dynamics in an anaerobic plug-flow type bioreactor treating swine manure显示文摘 | Roy C S Talbot G Topp E | 2009 | Water Re- search2009，43，1： | 1 |
| 14 | Endoscopic management of polypoid early colon cancer 显示文摘 | Williams C B Saunders B P Talbot I C | 2000 | World J Surg2000，24，9： | 1 |
| 15 | Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis显示文摘 | Talbot PJ Pauqette JS Ciurli C | 1996 | Ann Neurol1996，39，： | 1 |
| 16 | Fast exact leave-one-out Cross- Validation of sparse least-squares support vector machines显示文摘 | CAWLEY G C TALBOT N L | 2004 | Neural Networks2004，17，： | 1 |
| 17 | Bony Abnormalitied of the Paranasal Sinuses in Patients with Wegener's Granulomatosis显示文摘 | Yang C Talbot J M Hwang PH | 2001 | Am J Rhinol2001，15，2： | 1 |
| 18 | A maximumlikelihood approach to fitting equilibrium models of microsatellite evolution 显示文摘 | Sibly R M Whittaker J C Talbot M | 2001 | Mol Biol Evol2001，18，： | 1 |
| 19 | Autophagic fungal cell death is necessary for infection by the rice blast fungus显示文摘 | Veneault-Fourrey C Barooah M Egan M Wakley G Talbot N J | 2006 | Science2006，312，： | 1 |
| 20 | Cardiotoxicity of the anthrapyrazole CI941, not due to free radical fomation显示文摘 | Talbot D C Smith I E | 1991 | Proc Amer Assoc Cancer Res1991，32，： | 1 |
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