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95篇 您的检索式:作者名="Tabor H"
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1Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments.Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen 2019World Journal of Gastroenterology2019,25,33:3
2Escherichia coli thiore- doxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7 显示文摘TABOR S HUBER H E RICHARDSON C C 1987J Biol Chem1987,262,16:1
3A new type cylindrical magnetic domain(bubble isomers)显示文摘TABOR W J BOBECK A H VELLA-COLEIRO G P 1972Bell Syst Tech J1972,51,:1
4Polyamines protect Escherichia coli cells from the toxic effect of oxygen显示文摘Chattopadhyay MK Tabor CW Tabor H 0,,:1
5Persistence of genetically altered fields in head and neck cancer patients:biological and clinical implications显示文摘Tabor M P Brakenhoff R H Van Houten V M 2001Clin Cancer Res2001,7,6:1
6Persistence of genetically altered fields in head and neck cancer patients:biological and clinical implications显示文摘Maarten P Tabor Ruud H Brakenhoff Viola M M van Houten 2001Clinical Cancer Research2001,7,6:1
7Polyethylene glycol (PEG) hydrogel dural sealant and collagen dural graft matrix in transsphenoidal pituitary surgery for prevention of postoperative cere- brospinal fluid leaks 显示文摘Clinton J Burkett Samip Patel Mark H Tabor 2011Journal of Clinical Neuroscience2011,18,11:1
8Empirical analysis of audit uncertainty qualifications 显示文摘T B Bell and R H Tabor 1991Journal of Accounting Research1991,1991,:1
9Multiple head and neck tumors frequently originate from a single reneoplastic lesion显示文摘Tabor M P Brakenhoff R H Ruijter-Schippers H J 2002Am J Pathol2002,161,:1
10The Beith Ha' arava 5MW solar pond power plant progress report显示文摘H Tabor B Doron 1990Solar Energy1990,45,4:1
11Regulation of gene expression by SREBP and SCAP显示文摘Edwards P A Tabor D Kast H R 2000Biochim Biophys Acta2000,1529,13:1
12Multiple head and neck tumors frequently originate from a single preneoplastic lesion显示文摘Maarten P Tabor Ruud H Brakenhoff Henrique J RuijterSchippers 2002American Journal of Pathology2002,161,3:1
13Polyamines 显示文摘Tabor CW Tabor H 1984Annual Review of Biochemistry1984,53,:1
14Oestrogen-mediated cardioprotection following ischaemia and reperfusion is mimicked by an oestrogen receptor (ER)alpha agonist and unaffected by an ER beta antagonist显示文摘Jeanes H L Tabor C Black D 2008Endocrinol2008,197,3:1
15Solar pondsa review 显示文摘Tabor H 1981Solar Energy1981,27,3:1
16Aerosolized surfactant treatment of preterm lambs显示文摘Lewis J F Ikegami M Jobe A H Tabor B 1991J Appl Physiol1991,70,:1
17Regulation of gene expression by SREBP and SCAP显示文摘Edwards P A Tabor D Kast H R 0,,:1
18A tensorial approach to computational continuum mechanics using Object - Orientated techniques显示文摘Weller H G Tabor G Jasak H 1998Computers in Physics1998,12,6:1
19Inventive principles with applications in education显示文摘MARSH DANA G WATERS FAITH H MARSH TABOR D 2004The TRIZ Journal2004,,4:1
20Polyamines 显示文摘Tabor C W Tabor H 1976Annu Rev Biochem1976,53,:1
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