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| 1 | 自体腘绳肌肌腱与新鲜冷冻同种异体胫前肌肌腱移植对前交叉韧带重建效果的影响显示文摘随着内固定装置和更加精确的隧道技术的发展,自体腘绳肌肌腱和同种异体胫前肌肌腱移植重建前交叉韧带(anterior cruciate ligament,ACL)开始普遍应用于关节外科。尽管自体组织移植具有很高的成功率,但一些外科医师还是倾向于采用同种异体移植物,以避免供区并发症;但同种异体移植物的有效性目前仍存在争议。本研究旨在通过前瞻性多中心随机对照实验研究,比较自体腘绳肌肌腱与新鲜冷冻同种异体胫前肌肌腱移植重建ACL在临床疗效和膝关节稳定性方面的差异。 | Lawhorn KW Howell SM Traina SM 沈洪园 黄华扬 | 2012 | 中国骨科临床与基础研究杂志2012，4，5： | 9 |
| 2 | Endoscopic treatment of biliary complications after liver transplantation显示文摘AIM:To evaluate the efficacy of endoscopic treatment in patients who undergo OLTx or LRLTx and develop biliary complications. METHODS:This is a prospective, observational study of patients who developed biliary complications, after OLTx and LRLTx, with duct-to-duct anastomosis performed between June 2003 and June 2007. Endoscopic Retrograde Cholangiopancreatography (ERCP) was considered unsuccessful when there was evidence of continuous bile leakage despite endoscopic stent placement, or persistence of stenosis after 1 year, despite multiple dilatation and stent placement. When the ERCP failed, a percutaneous trans-hepatic approach (PTC) or surgery was adopted. RESULTS: From June 2003 to June 2007, 261 adult patients were transplanted in our institute, 68 from living donors and 193 from cadaveric donors. In the OLTx group the rate of complications was 37.3%, while in the LRLTx group was 64.7%. The rate of ERCP failure was 19.4% in the OLTx group and 38.6% in LRLTx group. In OLTx group, 1 patient was re- transplanted and 8 patients died. In the LRLTx group, 2 patients underwent OLTx and 8 patients died. The follow-up was 23.3 ± 13.13 mo and 21.02 ± 14.10 mo, respectively.CONCLUSION: Although ERCP is quite an effective mode of managing post-transplant bile duct complications, a significant number of patients need other types of approach. Further prospective studies are necessary in order to establish whether other endoscopic protocols or new devices, could improve the current results. | Ilaria Tarantino Luca Barresi Ioannis Petridis Riccardo Volpes Mario Traina Bruno Gridelli | 2008 | World Journal of Gastroenterology2008，14，26： | 6 |
| 3 | 胰腺的膀胱的损害: 内视镜的超声形态学和内视镜的超声罚款针渴望帮助怎么开诊断难题显示文摘 Cystic lesions of the pancreas are being diagnosed with increasing frequency,covering a vast spectrum from benign to malignant and invasive lesions.Numerous investigations can be done to discriminate between benign and non-evolutive lesions from those that require surgery.At the moment,there is no single test that will allow a correct diagnosis in all cases.Endoscopic ultrasound(EUS) morphology,cyst fluid analysis and cytohistology with EUS-guided fine needle aspiration can aid in this difficult diagnosis. | Luca Barresi Ilaria Tarantino Antonino Granata Gabriele Curcio Mario Traina | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，6： | 5 |
| 4 | Simultaneous endoscopic ultrasound fine needle aspiration and endoscopic retrograde cholangio-pancreatography:Evaluation of safety显示文摘AIM: To investigate the rate of complications of endoscopic retrograde cholangio-pancreatography (ERCP) performed immediately after endoscopic ultrasound fine needle aspiration (EUS-FNA) in a large series of patients. METHODS: Patients with the following conditions were considered candidates for EUS-FNA and ERCP: diagnosis of locally advanced or metastatic pancreatic lesion not eligible for surgery, and patients with pancreatic lesion of unknown nature causing jaundice. Data were prospectively collected on the following parameters: indication for FNA, EUS findings, pathological diagnosis, procedure duration of EUS-FNA and combined EUS-FNA and ERCP, and immediate and late complications. RESULTS: From January 2004 to October 2006, 72 patients were deemed eligible for combined EUS and ERCP. In 25/72 EUS-FNA was performed to obtain a pathology diagnosis of lesions causing biliary obstruction, and ERCP sequentially performed to drain the biliary system. No immediate complications occurred except for two mild bleeding episodes post sphincterotomy. No late complications were recorded except for one patient who experienced fever, promptly recovered with antibiotic therapy. CONCLUSION: Simultaneous approach appears to be feasible and safe. When possible, this can be considered the reference standard to avoid double sedation and reduce duration of the procedure and hospital stay. | Ilaria Tarantino Luca Barresi Marta Di Pisa Mario Traina | 2007 | World Journal of Gastroenterology2007，13，28： | 4 |
| 5 | 盖住的自我有为避免 stent 赶出的胰腺的 pseudocyst 的在内的闪耀的塑料的可扩充的金属性的 stent显示文摘 Endoscopic ultrasound-guided drainage has recently been recommended for increasing the drainage rate of endoscopically managed pancreatic fluid collections and decreasing the morbidity associated with conventional endoscopic trans-mural drainage. The type of stent used for endoscopic drainage is currently a major area of interest. A covered self expandable metallic stent (CSEMS) is an alternative to conventional drainage with plastic stents because it offers the option of providing a larger-diameter access fi stula for drainage, and may increase the fi nal success rate. One problem with CSEMS is dislodgement, so a metallic stent with flared or looped ends at both extremities may be the best option. An 85-year-old woman with severe comorbidity was treated with percutaneous approach for a large (20 cm) pancreatic pseudocyst with corpuscolated material inside. This approach failed. The patient was transferred to our institute for EUS-guided transmural drainage. EUS confi rmed a large, anechoic cyst with hyperechoic material inside. Because the cyst was large and contained mixed and corpusculated fluid, we used a metallic stent for drainage. To avoid migration of the stent and potential mucosal growth above the stent, a plastic prosthesis (7 cm, 10 Fr) with flaps at the tips was inserted inside the CSEMS. Two months later an esophagogastroduodenoscopy was done, and showed patency of the SEMS and plastic stents, which were then removed with a polypectomy snare. The patient experienced no further problems. | Ilaria Tarantino Marta Di Pisa Luca Barresi Gabriele Curcio Antonino Granata Mario Traina | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，4： | 3 |
| 6 | Endoscopic ultrasound guided biliary drainage显示文摘Endoscopic retrograde cholangio-pancreatography is the most appropriate technique for treating common bile duct and pancreatic duct stenosis secondary to benign and malignant diseases. Even if the procedure is performed by skillful endoscopist, there are patients in whom endoscopic stent placement is not possible. Common causes of failure include complex peripapillary diverticula, prior surgery procedures, tumor involvement of the papilla, biliary sphincter stenosis, and impacted stones. Percutaneous trans-hepatic biliary drainage (PTBD) and surgical intervention carry morbidity and mortality. Recently endoscopic ultrasonography-guided biliary drainage has been reported as an alternative technique. Endoscopic ultrasonography- guided biliary drainage using either direct access or a rendezvous technique has attracted attention as an alternative procedure to PTBD, with a technical success between 75%-100% and with low complication rate. We have reviewed published data on EUS guided biliary drainage procedures with the aim of summarizing the efficacy and safety of this promising method. | Ilaria Tarantino Luca Barresi Carlo Fabbri Mario Traina | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，7： | 3 |
| 7 | Tulip bundle technique and fibrin glue injection:Unusual treatment of colonic perforation显示文摘We report a case of a 63-year-old male who experienced an iatrogenic sigmoid perforation repaired combining three endoscopic techniques.The lesion was large and irregular with three discrete perforations,therefore,we decided to close it by placing one clip per perforation,and then connecting all the clips with two endoloops.Finally we chose to use a fibrin glue injection to obtain a complete sealing.Four days after the colonoscopy the patient underwent a laparoscopic right hemicolectomy due to evidence of a large polyp of the caecum with high grade dysplasia and focal carcinoma in situ.Inspection of the sigma showed complete repair of the perforation.This report underlines how a conservative approach,together with a combination of various endoscopic techniques,can resolve complicated iatrogenic perforations of the colon. | Filippo Mocciaro Gabriele Curcio Ilaria Tarantino Luca Barresi Marco Spada Sergio Li Petri Mario Traina | 2011 | World Journal of Gastroenterology2011，17，8： | 2 |
| 8 | A case of biliary stones and anastomotic biliary stricture after liver transplant treated with the rendez-vous technique and electrokinetic lithotritor显示文摘The paper studies the combined radiologic and endoscopic approach (rendez vous technique) to the treatment of the biliary complications following liver transplant. The 'rendez-vous' technique was used with an electrokinetic lithotripter, in the treatment of a biliary anastomotic stricture with multiple biliary stones in a patient who underwent orthotopic liver transplant. In this patient, endoscopic or percutaneous transhepatic management of the biliary complication failed. The combined approach, percutaneous transhepatic and endoscopic treatment (rendez-vous technique) with the use of an electrokinetic lithotritor, was used to solve the biliary stenosis and to remove the stones. Technical success, defined as disappearance of the biliary stenosis and stone removal, was obtained in just one session, which definitively solved the complications. The combined approach of percutaneous transhepatic and endoscopic (rendez-vous technique) treatment, in association with an electrokinetic lithotritor, is a safe and feasible alternative treatment, especially after the failure of endoscopic and/or percutaneous trans-hepatic isolated procedures. | Marta Di Pisa Mario Traina Roberto Miraglia Luigi Maruzzelli Riccardo Volpes Salvatore Piazza Angelo Luca Bruno Gridelli | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 9 | Polymorphisms in VEGF, progesterone receptor and IL-1 receptor genes in women with recurrent spontaneous abortion显示文摘 | évelyn Traina Silvia Daher Antonio Fernandes Moron Sue Yazaki Sun Camila Sommerauer Franchim Rosiane Mattar | 2010 | Journal of Reproductive Immunology2010，，： | 2 |
| 10 | Variceal bleeding from ileum identified and treated by single balloon enteroscopy显示文摘We report a case of acute uncontrolled gastrointestinal bleeding in a patient with liver cirrhosis.The upper and lower endoscopy were negative for bleeding lesions. We decided to perform the examination of the small bowel using single-balloon enteroscopy.The lower enteroscopy revealed signs of bleeding from varices of the ileum.In this report,we showed that the injection of a sclerosant solution can be accomplished using a freehand technique via the single balloon enteroscopy. | Mario Traina Ilaria Tarantino Luca Barresi Filippo Mocciaro | 2009 | World Journal of Gastroenterology2009，15，15： | 2 |
| 11 | Closure techniques in exposed endoscopic full-thickness resection:Overview and future perspectives in the endoscopic suturing era显示文摘Exposed endoscopic full-thickness resection(EFTR)without laparoscopic assistance is a minimally invasive natural orifice transluminal endoscopic surgery technique that is emerging as a promising effective and safe alternative to surgery for the treatment of muscularis propria-originating gastric submucosal tumors.To date,various techniques have been used for the closure of the transmural postEFTR defect,mainly consisting in clip-and endoloop-assisted closure methods.However,the recent advent of dedicated tools capable of providing full-thickness defect suture could further improve the efficacy and safety of the exposed EFTR procedure.The aim of our review was to evaluate the efficacy and safety of the different closure methods adopted in gastric-exposed EFTR without laparoscopic assistance,also considering the recent advent of flexible endoscopic suturing. | Antonino Granata Alberto Martino Dario Ligresti Francesco Paolo Zito Michele Amata Giovanni Lombardi Mario Traina | 2021 | World Journal of Gastrointestinal Surgery2021，13，7： | 2 |
| 12 | NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2^(V617F)-positive myeloproliferative neoplasm cells显示文摘Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms(MPN);in this pathway,IRS2 is involved in the malignant transformation induced by JAK2^(V617F),and upregulation of IGF1R signaling induces the MPN phenotype.NT157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid tumors.Herein,we aimed to characterize the molecular and cellular effects of NT157 in JAK2^(V617F)positive MPN cell lines(HEL and SET2)and primary patient hematopoietic cells.In JAK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/M phase(p<0.05).NT157 treatment inhibited IRS1/2,JAK2/STAT,and NFκB signaling,and it activated the AP-1 complex,downregulated four oncogenes(CCND1,MYB,WT1,and NFKB1),and upregulated three apoptotic-related genes(CDKN1A,FOS,and JUN)(p<0.05).NT157 induced genotoxic stress in a JAK2/STAT-independent manner.NT157 inhibited erythropoietin-independent colony formation in cells from polycythemia vera patients(p<0.05).These findings further elucidate the mechanism of NT157 action in a MPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for MPN. | Bruna Alves Fenerich Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves Juan Luiz Coelho-Silva Renata Scopim-Ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon Brian J.Druker Eduardo Magalhães Rego João Agostinho Machado-Neto Fabiola Traina | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 13 | Right hepatic lobe living donation: A 12 years single Italian center experience显示文摘Mini invasive techniques are taking over conventional open liver resections in the setting of left lateral segmentectomy for living liver donation,and hydride procedure are being implemented for the living related right hepatectomy.Our center routinely performs laparoscopic left lateral segmentectomy for pediatric recipient and has been the first in the Europe performing an entirely robotic right hepatectomy.Great emphasis is posed on living donor safety which is the first priority during the entire operation,then the most majority of our procedures are still conventional open right hepatectomy(RHLD),defined as removal of a portion of liver corresponding to Couinaud segments 5-8,in order to obtain a graft for adult to adult living related liver transplant.During this 10 years period some changes,herein highlighted,have occurred to our surgical techniques.This study reports the largest Italian experience with RHLD,focused on surgical technique evolution over a 10 years period.Donor safety must be the first priority in right-lobe living-related donation:the categorization of complications of living donors,specially,after this'highly sensitive'procedure,reflects the need for prompt and detailed reports. | Salvatore Gruttadauria Duilio Pagano Davide Cintorino Antonio Arcadipane Mario Traina Riccardo Volpes Angelo Luca Giovanni Vizzini Bruno Gridelli Marco Spada | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 14 | Two-stage surgical treatment for septic non-union of the forearm显示文摘AIM To investigate the effectiveness of a two-stage surgical procedure for the treatment of septic forearm non-union.METHODS Septic non-unions are rare complications of forearm fractures. When they occur, they modify the relationship between forearm bones leading to a severe functional impairment. Treatment is challenging and surgery and antibiotic therapy are required to achieve infection resolution. It is even harder to obtain non-union healing with good functional results. The aim of this study is to present a two stages surgical treatment for septic forearm non-union with revision and temporary stabilization of the non-union until infection has cleared and subsequently perform a new synthesis with plate, opposite bone graft strut and intercalary graft. We retrospectively reviewed 18 patients with a mean age at the time of primary injury of 34.5 years(19-57 years) and a mean follow-up of 6 years(2-10 years). All patients presented an atrophic nonunion with a mean length of the bone defect of 1.8 cm(1.2-4 cm). Complications and clinical results after surgical treatment were recorded. RESULTS Mean time to resolution of the infectious process was 8.2 wk(range 4-20 wk) after the first surgery and specific antibiotic therapy. All the non-union healed with an average time of 5 mo(range 2-10 mo) after the second step surgery. Cultures on intraoperative samples werepositive in all cases. No major intraoperative complications occurred. Two patients developed minor complications and one needed a second surgical debridement for infection resolution. At the last follow-up functional results were excellent in 5(27.8%) patients, satisfactory in 10(55.5%) and unsatisfactory in 3(16.7%) patients. No activities of daily living(ADLs) limitations were reported by 12(66.6%) patients, slight by 3(16.6%) and severe limitation by 3(16.6%) patients. Mean visual analog scale at the last follow-up was 1(0-3).CONCLUSION The two-step technique has proven to be effective to achieve resolution of the infectious process and union with good functional results and low rate of complications. | Fabrizio Perna Federico Pilla Matteo Nanni Lisa Berti Giada Lullini Francesco Traina Cesare Faldini | 2017 | World Journal of Orthopedics2017，8，6： | 2 |
| 15 | Lonidamine transiently affects spermatogenesis in pubertal CD1 mice显示文摘 | Traina ME Guarino M Urbani E | 2005 | Contraception2005，72，4： | 1 |
| 16 | Updates in cytogenetics and molecular markers in MDS显示文摘 | Tiu RV Visconte V Traina F | | 0，，： | 1 |
| 17 | Biotite dissolution and Cr (VI) reduction at elevated pH and ionic strength 显示文摘 | He Y T Bigham J M Traina S J | 2005 | Geochimiea et Cosmochimica Acta2005，69，： | 1 |
| 18 | Bevacizumab in the treatment of metastatic breast canc-er显示文摘 | TRAINA T A | 2009 | Oncology(Williston Park)2009，23，4： | 1 |
| 19 | A formulation of the cauchy method suitable for the synthesis of lossless circuit models of microwave filters from lossy measurements 显示文摘 | MACCHIARELLA G TRAINA D | 2006 | IEEE Microw Wireless Compon Letter2006，16，5： | 1 |
| 20 | The effects of organic and conventional management on biological cutive soil organic matter fraction显示文摘 | Wander M M Traina S J Srinne B R | 1994 | Science Society of America Journal1994，58，： | 1 |
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