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| 1 | 对比经肛全直肠系膜切除术与腹腔镜全直肠系膜切除术:一项多中心III期随机临床试验(TaLaR试验)方案显示文摘背景:全直肠系膜切除术是直肠癌治疗的标准手术方法。经肛全直肠系膜切除术(taTME)是治疗低位直肠癌的新术式。既往研究表明,与腹腔镜全直肠系膜切除术(lapTME)相比,taTME应用于低位直肠癌患者可提供更高质量的手术标本,但其长期肿瘤学结果仍需进一步观察。因此,我们设计了这个非劣效性临床试验(TaLaR试验),比较taTME与lapTME治疗直肠癌的短期和长期结果。方法/设计:TaLaR试验是一项多中心III期随机对照试验。研究对象为经磁共振成像、直肠指检或结肠镜检查被诊断为位于腹膜反折以下的直肠癌,若肿瘤分期≤cT3N2直接手术,若>cT3N2则先行新辅助治疗。通过计算,本研究需纳入1,114例患者(每组557例)。纳入病例随机分配到taTME或lapTME组。本研究的主要终点是3年无病生存率(DFS)和5年总生存率(OS)。次要终点包括手术标本质量、围手术期结果、骨盆和肛门功能以及生活质量。讨论:我们认为,TaLaR试验将阐明taTME是否可以达到与lapTME相似的肿瘤学结果,以及是否可改善直肠癌患者的手术标本质量及恢复情况。 | Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang | 2021 | Gastroenterology Report2021，9，1： | 2 |
| 2 | Highly dispersed 1 nm Pt Pd bimetallic clusters for formic acid electrooxidation through a CO-free mechanism显示文摘Direct formic acid fuel cell(DFAFC) is an important research project in clean energy field.However,commercialization of DFAFC is still largely limited by the available catalysts with unsatisfied activity,durability and cost for formic acid electrooxidation(FAEO).Using Pt-and Pd-based nanoclusters as electrocatalysts is a particularly promising strategy to solve the above problem,but two attendant problems need to be solved firstly.(Ⅰ) The controllable synthesis of practicable and stable sub-2 nm clusters remains challenging.(Ⅱ) The catalyzing mechanism of sub-2 nm metal clusters for FAEO has not yet completely understood.Herein,different from traditional solution synthesis,by designing a novel supporting material containing electron-rich and electron-deficient functional groups,size-and dispersioncontrollable synthesis of ~1 nm PtPd nanoclusters is realized by an electrochemical process.The electrocatalytic properties and reaction mechanism of the PtPd nanoclusters for the FAEO were studied by different electrochemical techniques,in-situ fourier transform infrared(FTIR) spectra and density functional theory(DFT) calculations.The tiny PtPd nanoclusters have much higher catalytic activity and durability than commercial Pt/C,Pd/C and 3.5 nm PtPd nanoparticles.The present study shows that the metalreactant interaction plays a decisive role in determining the catalytic activity and cluster-support interaction plays a decisive role in enhancing the durability of electrocatalyst.The ratio and arrangement of Pt and Pd atoms on the surface of 1 nm PtPd cluster as well as the overall valence state,d-band center and specific surface area make them exhibit different catalytic performance and reaction mechanism from nanoparticle catalysts.In addition,in situ FTIR and DFT calculations showed that on the surface of PtPd clusters,the generation of CO_(2)through trans-COOH intermediate is the most optimal reaction pathway for the FAEO. | Zhongying Fang Ziwei Zhang Shemsu Ligani Fereja Jinhan Guo Xinjie Tong Yue Zheng Rupeng Liu Xiaolong Liang Leting Zhang Zongjun Li Wei Chen | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 3 | Underground space use of urban built-up areas in the central city of Nanjing:Insight based on a dynamic population distribution显示文摘With the expansion of cities and the emergence of various urban problems,urban underground space has been developed as a solution.In China’s urban transition context,there is a need for the development of underground space in urban built-up areas.In this casestudy of the central city of Nanjing,we used spatial analysis and statistical methods to characterize the underground space use of urban built-up areas from a dynamic spatiotemporal perspective.We first analyzed the relationship between the population distribution and the underground space use of the central city of Nanjing based on a Baidu heat map,which can reflect the real-time population distribution,and then,we explored the spatiotemporal characteristics and spatial structure of the underground space use in urban built-up areas.The analysis results provide a reference for planning to improve and optimize the layout of underground space in the central city of Nanjing and,more generally,for the stock-type planning of underground space in urban built-up areas. | Yulu Chen Zhilong Chen Dongjun Guo Ziwei Zhao Tong Lin Chenhao Zhang | 2022 | Underground Space2022，7，5： | 0 |
| 4 | Interface wave propagation characteristics of liquid-immersed porous cylinder显示文摘 | HAN Qingbang XU Zhouchen TONG Ziwei QI Lihua WANG Peng SHAN Minglei ZHU Changping | 2018 | Chinese Journal of Acoustics2018，37，2： | 0 |
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