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| 1 | TOWARD COLLECTIVE INTELLIGENCE OF ONLINE COMMUNITIES:A PRIMITIVE CONCEPTUAL MODEL显示文摘Inspired by the ideas of Swarm Intelligence and the'global brain',a concept of'community intelligence'is suggested in the present paper,reflecting that some'intelligent'features may emerge in a Web-mediated online community from interactions and knowledge-transmissions between the commumty members.This possible research field of community intelligence is then examined under the backgrounds of'community'and'intelligence'researches.Furthermore,a conceptual model of community intelligence is developed from two views.From the structural view,the community intelligent system is modeled as a knowledge supernetwork that is comprised of triple interwoven networks of the media network,the human network,and the knowledge network.Furthermore,based on a dyad of knowledge in two forms of'knowing'and'knoware',the dynamic view describes the basic mechanics of the formation and evolution of'community intelligence'.A few relevant research issues are shortly discussed on the basis of the proposed conceptual model. | Shuangling LUO Haoxiang XIA Taketoshi YOSHIDA Zhongtuo WANG | 2009 | Journal of Systems Science and Systems Engineering2009，18，2： | 10 |
| 2 | 对比经肛全直肠系膜切除术与腹腔镜全直肠系膜切除术:一项多中心III期随机临床试验(TaLaR试验)方案显示文摘背景:全直肠系膜切除术是直肠癌治疗的标准手术方法。经肛全直肠系膜切除术(taTME)是治疗低位直肠癌的新术式。既往研究表明,与腹腔镜全直肠系膜切除术(lapTME)相比,taTME应用于低位直肠癌患者可提供更高质量的手术标本,但其长期肿瘤学结果仍需进一步观察。因此,我们设计了这个非劣效性临床试验(TaLaR试验),比较taTME与lapTME治疗直肠癌的短期和长期结果。方法/设计:TaLaR试验是一项多中心III期随机对照试验。研究对象为经磁共振成像、直肠指检或结肠镜检查被诊断为位于腹膜反折以下的直肠癌,若肿瘤分期≤cT3N2直接手术,若>cT3N2则先行新辅助治疗。通过计算,本研究需纳入1,114例患者(每组557例)。纳入病例随机分配到taTME或lapTME组。本研究的主要终点是3年无病生存率(DFS)和5年总生存率(OS)。次要终点包括手术标本质量、围手术期结果、骨盆和肛门功能以及生活质量。讨论:我们认为,TaLaR试验将阐明taTME是否可以达到与lapTME相似的肿瘤学结果,以及是否可改善直肠癌患者的手术标本质量及恢复情况。 | Liang Kang Ziwei Zeng Shuangling Luo Hong Zhang Quan Wang Mingyang Ren Miao Wu Weidong Tong Qing Xu Yi Xiao Aiwen Wu Yuan-Guang Chen Bo Feng Zhanlong Shen Liang Huang Xingwei Zhang Minhua Zheng Jian-Ping Wang | 2021 | Gastroenterology Report2021，9，1： | 2 |
| 3 | A study on eoevolutionary dy- namics of knowledge diffusion and social network structure 显示文摘 | SHUANGLING LUO | 2015 | Expert Systems with Applications2015，7，42： | 1 |
| 4 | A COUPLED DYNAMIC MODEL OF BRAND ACCEPTANCE AND PROMOTIVE INFORMATION SPREADING显示文摘 | Qian Pan Haoxiang Xia Shuangling Luo | 2018 | Journal of Systems Science and Systems Engineering2018，27，5： | 0 |
| 5 | Iridium photosensitizer constructed liposomes with hypoxia-activated prodrug to destrust hepatocellular carcinoma显示文摘Hypoxic tumor microenvironment is a major challenge for photodynamic therapy(PDT). To overcome this problem, PDT combined hypoxia-activated chemotherapy is a promising strategy for hypoxic cancer therapy. Herein, a multifunctional liposome(AQ4N-Ir1-sorafenib-liposome) is prepared by encapsulating a hypoxia-activated prodrug AQ4N, a photosensitizer iridium(III) complex and hepatocellular carcinoma(HCC) targeting drug sorafenib, for synergistic therapy of HCC. Ir1-mediated PDT upon irradiation induces ROS generation and hypoxic environment, which leads to the disassembly of the liposome and activates the antitumor activity of AQ4N. Meantime, the co-delivered sorafenib could effectively target therapy of HCC. It is noted that ferroptosis mechanism is proved during the treatment. This work contributes to the design of hypoxia-responsive multifunctional liposome for combination of chemotherapy, targeting therapy and PDT. It is a promising strategy for hypoxic HCC therapy. | Shuangling Luo Chao Liang Qianling Zhang Pingyu Zhang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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