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| 1 | Science:'记忆碎片'是真的吗?显示文摘半个多世纪以来,神经学家们一直以为长期记忆是由于多个短期记忆储存起来形成的。而最近一项对记忆形成的神经回路的研究则表明这一说法有可能是错的,因为两种类型的记忆(长期与短期)能够同时产生。这项研究是由来自MIT的研究者们做出。他们参考了此前标记特殊”记忆”细胞的手段,并更进一步地强制性使小鼠对特定的记忆作出反应。并且断开了长期与短期记忆的连接。 | Takashi Kitamura Mark D. Morrissey Lillian M. Smith Roger L. Redondo | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Reduced stress defense in heme oxygenase 1 deficient cells显示文摘 | POSS K D TONEGAWA S | | 0，，： | 1 |
| 3 | Reduced stress defense in heine oxygenase-1- deficient cells显示文摘 | Poss KD Tonegawa S | 1997 | Proc Natl Acad Sci USA1997，94，10： | 1 |
| 4 | Genetic neuroscience of mammalian learning and memory显示文摘 | Tonegawa S Nakazawa K Wilson MA | 2003 | Philos Trans R SocLond B Biol Science2003，358，1432： | 1 |
| 5 | Analysis of epitope recognition of antibodies induced by DNA immunization against hemagglutinin protein of influenza A virus显示文摘 | Tonegawa K Nobusawa E Nakajima K | 2003 | Vaccine2003，21，23： | 1 |
| 6 | An Important Role of Neural Activity-Dependent CaMKIV Signaling in the Consolidation of Long-Term Memory显示文摘 | Kang H Sun LD Tonegawa S | 2001 | Cell2001，106，6： | 1 |
| 7 | Deodorization of swine manure using minced horseradish roots and peroxides 显示文摘 | Govere EM Tonegawa M Bruns MA | 2005 | J Agric Food Chem2005，53，： | 1 |
| 8 | Characterization of trap levels in long-duration phosphor crystals 显示文摘 | Katsumata T Toyomane S Tonegawa A | 2002 | Journal of Crystal Growth2002，，1： | 1 |
| 9 | Reduced stress defense in hemeoxygenase 1-deficient cells显示文摘 | Poss KD Tonegawa S | 1997 | Proc Natl Acad Sci USA1997，94，10： | 1 |
| 10 | Synaptic plasticity, placecells and spatial memory ; study with second generationknockouts 显示文摘 | Wilson M A Tonegawa S | 1997 | Trends Neurosci1997，20，3： | 1 |
| 11 | Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma显示文摘Uterine tumors are the most common type of gynecologic neoplasm.Uterine leiomyosarcoma(LMS)is rare,accounting for 2%to 5%of tumors of the uterine body.Uterine LMS develops more often in the muscle tissue layer of the uterine body than in the uterine cervix.The development of gynecologic tumors is often correlated with female hormone secretion;however,the development of uterine LMS is not substantially correlated with hormonal conditions,and the risk factors are not yet known.Radiographic evaluation combined with PET/CT can be useless in the diagnosis and surveillance of uterine LMS.Importantly,a diagnostic biomarker,which distinguishes malignant LMS and benign tumor leiomyoma(LMA)is yet to be established.Accordingly,it is necessary to analyze risk factors associated with uterine LMS in order to establish a method of treatment.LMP2-deficient mice spontaneously develop uterine LMS,with a disease prevalence of~40%by 14 months of age.It is therefore of interest whether human uterine LMS shows a loss of LMP2 expression.We found LMP2 expression is absent in human LMS,but present in human LMA.Therefore,defective LMP2 expression may be one of the risk factors for LMS.LMP2 is potentially a diagnostic biomarker for uterine LMS,and gene therapy with LMP2-encording DNA may be a new therapeutic approach. | Takuma Hayashi Akiko Horiuchi Kenji Sano Nobuyoshi Hiraoka Yae Kanai Tanri Shiozawa Susumu Tonegawa Ikuo Konishi | 2010 | Protein & Cell2010，1，8： | 1 |
| 12 | Reduced stress defense in heme oxygenase 1-deficient ceils 显示文摘 | Poss K D Tonegawa S | 1997 | Proc Natl Acad Sci USA1997，94，10： | 1 |
| 13 | Interferon-alpha therapy for chronic active Epstein-Barr virus infection:Potential effect on the development of T-lymphoproliferative disease显示文摘 | Sakai Y Ohga S Tonegawa Y | 1998 | J Pediatr Hematol Oncol1998，20，4： | 1 |
| 14 | Translational regulatory mechanisms in persistent forms of synaptic plasticity 显示文摘 | Kdleher RJ Govindamjan A Tonegawa S | 2004 | Neuron2004，44，1： | 1 |
| 15 | Reduced stress defense in heme oxygenase 1-deficient cells显示文摘 | Poss K D Tonegawa S | 1997 | Proceedings of the National Academy of Sciences USA1997，94，10： | 1 |
| 16 | Interferon-alpha therapy for chronic active Epstein-Barr virus infection: potential effect on the development of T-lymphoproliferative disease显示文摘 | Sakai Y Ohga S Tonegawa Y et at | 1998 | 1 Pediatr Hematol Oncol1998，20，4： | 1 |
| 17 | Interferon-alpha therapy forchronic active Epstein-Barr virus infection: potential effect on thedevelopment of Tlymphoproliferative disease显示文摘 | Sakai Y Ohga S Tonegawa Y | 1998 | J Pediatr Hematol Oncol1998，20，4： | 1 |
| 18 | Adsorption of chlorinated organic-compounds on activated carbon from water显示文摘 | URANO K YAMAMOTO E TONEGAWA M | 1991 | Water Research1991，25，12： | 1 |
| 19 | Quin-one cross-linked polysaccharide hybrid Fiber显示文摘 | Kuboe Y Tonegawa H Ohkawa K | 2004 | Biomacro-molecules2004，5，： | 1 |
| 20 | Synaptic plasticity,place cells and spatial memory:study with second generation knockouts显示文摘 | Wilson MA Tonegawa S | 1997 | Trends Neurosci1997，20，： | 1 |
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