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| 1 | Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure显示文摘AIM To evaluate the effect of norepinephrine on inflammatory cytokine expression in ex vivo human monocytes and monocytic THP-1 cells. METHODS For human monocyte studies, cells were isolated from 12 chronic heart failure(HF)(66 ± 12 years, New York Heart Association functional class Ⅲ-Ⅳ, left ventricular ejection fraction 22% ± 9%) and 14 healthy subjects(66 ± 12 years). Monocytes(1 × 106/mL) were incubated with lipopolysaccharide(LPS) 100 ng/m L, LPS + norepinephrine(NE) 10-6 mol/L or neither(control) for 4 h. Tumor necrosis factor-alpha(TNFα) and interleukin-10(IL-10) production were determined by ELISA. Relative contribution of α- and β-adrenergic receptor subtypes on immunomodulatory activity of NE was assessed in LPSstimulated THP-1 cells incubated with NE, the α-selective agonist phenylephrine(PE), and the β-selective agonist isoproterenol(IPN). NE-pretreated THP-1 cells were also co-incubated with the β-selective antagonist propranolol(PROP), α2-selective antagonist yohimbine(YOH) or the α1-selective antagonist prazosin(PRAZ). RESULTS Basal TNFα concentrations were higher in HF vs healthy subjects(6.3 ± 3.3 pg/mL vs 2.5 ± 2.6 pg/mL, P = 0.004). Norepinephrine's effect on TNFα production was reduced in HF(-41% ± 17% HF vs -57% ± 9% healthy, P = 0.01), and proportionately with NYHA FC. Increases in IL-10 production by NE was also attenuated in HF(16% ± 18% HF vs 38% ± 23% healthy, P = 0.012). In THP-1 cells, NE and IPN, but not PE, induced a dosedependent suppression of TNFα. Co-incubation with NE and antagonists revealed a dose-dependent inhibition of the NE suppression of TNFα by PROP, but not by YOH or PRAZ. Dose-dependent increases in IL-10 production were seen with NE and IPN, but not with PE. This effect was also antagonized by PROP but not by YOH or PRAZ. Pretreatment of cells with IPN attenuated the effects of NE and IPN, but did not induce a response to PE.CONCLUSION NE regulation of monocyte inflammatory cytokine production may be reduced in moderate-severe HF, and may be mediated through β-adrenergic receptors. | Tien MH Ng Myron L Toews | 2016 | World Journal of Cardiology2016，8，10： | 4 |
| 2 | Mechanisms of Pulmonary Fibrosis显示文摘 | Victor J. Thannickal Galen B. Toews Eric S. White Joseph P. Lynch III Fernando J. Martinez | 2004 | Annual Review of Medicine2004，，： | 2 |
| 3 | Evaluation of spatial and temporal patterns of insect damage and aflatoxin level in the pre-harvest corn fields to improve management tactics显示文摘在与有一致基因背景的植物的一个玉米领域里的黄麴毒素污染的关系的昆虫损坏的空间、时间的模式很好没被理解。在昆虫损坏和黄麴毒素在的空间模式的以前的考试以后预先收获玉米地,我们进一步与二采样检验了喂圆块、喂核的昆虫损坏,和黄麴毒素水平的空间、时间的模式在在 2008 和 2009 预先收获。由每 ear/kernel-feeding 昆虫的喂的损坏(即,丝绸 / 圆块上的玉米一种有害幼虫 / 秋天粟蚕损坏,和玉米核由的褪色坏透臭虫) 并且玉米象鼻虫人口用五只耳朵在每个格子点被估计。采样数据在两年里处于昆虫损坏和黄麴毒素污染显示出域边效果。玉米象鼻虫比任何一个玉米一种有害幼虫更经常向聚集的分布趋于或坏透两年里的臭虫损坏。为黄麴毒素水平检测聚集的分发的频率是昆虫损坏评价的不到任何东西。坏透臭虫损坏和玉米象鼻虫数字更仔细比是玉米一种有害幼虫的与黄麴毒素水平被联系损坏。另外,空间时间的协会(χ
) 的索引证明玉米象鼻虫的数字被联系在之间第一(4 个星期预先收获) 并且秒(1 个星期预先收获) 所有地上的两年里的采样。相反,在来自 Belflower 农场上的地的第一和第二采样之间的玉米一种有害幼虫损坏,和黄麴毒素水平和玉米一种有害幼虫在 Lang 农场上从这块地损坏在 2009 被分裂。 | Xinzhi Ni Jeffrey P. Wilson Michael D. Toews G. David Buntin R. Dewey Lee Xin Li Zhongren Lei Kanglai He Wenwei Xu Xianchun Li Alisa Huffaker Eric A. Schmelz | 2014 | Insect Science2014，21，5： | 2 |
| 4 | Production of prostaglandins and leukotrienes by pathogenic fungi显示文摘 | Mairi C Noverr Galen B Toews | 2002 | Infection and Immunity2002，70，1： | 2 |
| 5 | Contribution of contact toxicity and wheat condition to mortality of stored product insects exposed to spinosad显示文摘 | Toews M D Subramanyam B | 2003 | Pest Management Science2003，59，5： | 1 |
| 6 | Lysophos-phatidic acid in airway function and disease显示文摘 | Toews ML Ediger TL Romberger DJ | 2002 | Biochim Biophys Acta2002，1582，13： | 1 |
| 7 | The relationship of inoculum size to lung bacterial clearance and phagocytic cell response in mice 显示文摘 | Toews GB Gross GN Pierce AK | 1979 | Am Rev Respir Dis1979，120，3： | 1 |
| 8 | Synergistic stimulation of airway smooth muscle cell mitogenesis显示文摘 | Toews ML Ediger TL | 2000 | Pharmacol Exp Ther2000，294，3： | 1 |
| 9 | Imaging and automated de-tection of Sitophilus oryzae (Coleoptera:Curculionidae)pupae in hard red winter wheat显示文摘 | Toews MD Pearson T C Campbell J F | | 0，，02： | 1 |
| 10 | A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmo- nary fibrosis viaCCL18 显示文摘 | Prasse A Pechkovsky DV Toews GB | 2006 | Am J Respir Crit Care Med2006，173，7： | 1 |
| 11 | Factors affecting cap-ture of Cryptolestes ferrugineus (Coleoptera: Laemoph-loediae) in traps placed in stored wheat显示文摘 | TOEWS M D PHILLIPS T W | 2002 | Journal of Economic Entomology2002，95，1： | 1 |
| 12 | Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins显示文摘 | Noverr MC Phare SM Toews GB | 2001 | Infect Immun2001，69，： | 1 |
| 13 | Efficient and robust model-to-image alignment using 3D scale-invariant features显示文摘 | Matthew Toews William M. Wells | 2012 | Medical Image Analysis2012，，： | 1 |
| 14 | Lysophosphatidic acid in airway function and disease 显示文摘 | Toews M L Ediger T L Romberger D J | 2002 | Biochim Biophys Acta2002，1582，13： | 1 |
| 15 | Mechanismsofpulmona-ryfibrosis显示文摘 | Thannickal VJ Toews GB White ES | 2004 | Annu Rev Med2004，55，3： | 1 |
| 16 | Steroid in idiopathic pulmonary fibrosis: a presective assessment of adverse reactions, response to therapy, and survival 显示文摘 | FLAHERTY KR TOEWS GB LYNCH JP III | 2001 | Am J Med2001，110，： | 1 |
| 17 | Macrophage recruitment in different models of nerve injury: lysozyme as a marker for active phagocytosis显示文摘 | Venezie R D Toews A D Morell P | 1995 | J Neurosci Res1995，40，1： | 1 |
| 18 | Mechanisms of pulmonary fibrosis显示文摘 | Thannickal VJ Toews GB White ES | 2004 | Annu Rev Med2004，55，： | 1 |
| 19 | Parameters related to lipid metabolism as markers of myelination in mouse brain 显示文摘 | Muse ED Jurevics H Toews AD | 2001 | Neurocbem2001，76，1： | 1 |
| 20 | A study of the influence of superimposed low-frequency modulation on the drilling process显示文摘 | Toews H G | 1998 | Precision Engineering1998，22，： | 1 |
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