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| 1 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 2 | Biological process of soil improvement in civil engineering:A review显示文摘The concept of using biological process in soil improvement which is known as bio-mediated soil improvement technique has shown greater potential in geotechnical engineering applications in terms of performance and environmental sustainability.This paper presents a review on the soil microorganisms responsible for this process,and factors that affect their metabolic activities and geometric compatibility with the soil particle sizes.Two mechanisms of biomineralization,i.e.biologically controlled and biologically induced mineralization,were also discussed.Environmental and other factors that may be encountered in situ during microbially induced calcite precipitation(MICP) and their influences on the process were identified and presented.Improvements in the engineering properties of soil such as strength/stiffness and permeability as evaluated in some studies were explored.Potential applications of the process in geotechnical engineering and the challenges of field application of the process were identified. | Murtala Umar Khairul Anuar Kassim Kenny Tiong Ping Chiet | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，5： | 9 |
| 3 | 橡胶树砧木对提高芽接树生长量和产量影响的初步研究结果显示文摘本文为PBFP(普兰伯沙多无性系采种区)和PB260砧木筛选研究的初步结果。本研究表明未经筛选的无性系PB260的种子砧木苗其接穗产量比PBFP的种子砧木苗的要低。选择切干时直茎粗<13mm的砧木(相当于芽接时直茎粗约10mm)能同时增加接穗生长量和开割率,这样也就使开割第一年的每公顷产量提高。这个砧木茎粗筛选淘汰量,PB260种子的砧木苗约40%,PBFP的砧木苗约30%。在这样的淘汰强度下,两种砧木间的接穗平均产量差异缩小。本研究表明,为增加芽接树的生长量和整齐度,砧木的细致筛选是必要的,同时对不同种源的砧木必须采用不同的淘汰水平。较多的大田试验进一步证实了上述初步试验结果。 | Gan Lian Tiong 陈建白 | 1991 | 云南热作科技1991，14，2： | 7 |
| 4 | Using lanthanum to enhance the overall ignition, hardness, tensile and compressive strengths of Mg-0.5Zr alloy显示文摘Near dense Mg 0.5 wt.% Zr(0,1,2.5 and 4) wt.% La alloys were successfully synthesized by disintegrated melt deposition technique followed by hot extrusion and were characterized for their microstructural, ignition, hardness, tensile and compression properties. Combined effects of Zr and La assisted in significant grain refinement of Mg and Mg 0.5 wt.% Zr 4 wt.% La exhibited an average grain size as low as ~2.75 μm. High ignition temperature of ~645 oC was realized with Mg 0.5 wt.% Zr(1,2.5 and 4) wt.% La alloys. Microhardness value as high as ~103 Hv was observed with Mg 0.5 wt.% Zr 4 wt.% La alloy. Under room temperature tensile and compression loading, significant improvements in the strength properties of pure Mg with the addition of 0.5 wt.% Zr(0, 1, 2.5 and 4) wt.% La was observed. Mg 0.5 wt.% Zr 4 wt.% La exhibited the maximum 0.2% tensile and compression yield strengths of ~283 MPa and ~264 MPa, respectively. The tensile and compression fracture strain values of synthesized pure Mg were found to be unaffected with the addition of 0.5 wt.% Zr. But the tensile fracture strain reduced with the addition of La while the compressive fracture strain was unaffected. Minimal tensile-compression asymmetry(~1) was exhibited by Mg 0.5 wt.% Zr(1 and 2.5) wt.% La alloys. | Ganesh Kumar Meenashisundaram Tiong Hou Damien Ong Gururaj Parande Vyasaraj Manakari 向抒林 Manoj Gupta | 2017 | Journal of Rare Earths2017，35，7： | 5 |
| 5 | Cytogenetic and molecular aberrations of multiple myeloma patients: a single-center study in Singapore显示文摘 | LIM Alvin Soon Tiong LIM Tse Hui SEE Karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian LIM Sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung | 2013 | Chinese Medical Journal2013，，10： | 4 |
| 6 | 隧道开挖中地质风险评估的敏感性分析(英文)显示文摘在地下开挖工程进行中,地质风险评估是至关重要却也是最薄弱的环节。由于地下结构的不确定性、复杂性以及结构间多种关联性,对地质结构进行风险评估既困难又耗费成本。在对超大型隧道开挖工程进行风险评估时,为了降低前期准备过程耗费的时间与成本,风险管理经理更倾向于开挖重复地质断面时将其结构视为相似,并认为时间和成本的变化遵从线性关系。但事实上在对地质结构整体进行风险评估时,各个风险参数的相互依赖性和敏感性是未知的。针对进行地质风险评估时风险参数的敏感性和其会引起的变化,采用Monte Carlo模拟法确定了参与地质风险评估的相关风险参数的敏感性和波动性,例如开挖长度、岩石结构排列以及开挖方法等。采用的地质模型和场景以地质学家提出相关假设和较为常规的地质构造为基础。为了便于整合地质风险评估的各种因素,模拟时将不确定性量化为开挖进尺和成本。通过不同场景的模拟,确定地质风险评估中各个参数的敏感性。研究结果表明:地质结构和开挖进尺皆为独立影响因素,但当在不同的地质结构开挖长度相等时,其排列顺序却对开挖进尺和成本影响不大;在开挖重复地质结构时,开挖进尺和成本的变化遵从非线性关系。研究结果提供了一个对风险进行评估和管理的有效系统,可帮助决策者在管理大型复杂的隧道开挖项目时做出更好的判断。 | 白文琦 TIONG L K R | 2016 | 中国公路学报2016，29，8： | 4 |
| 7 | Wash water in waterworks:contaminants and process options for reclamation显示文摘Reclamation of clean water from filter backwash water was studied through pilot-scale experiments.The pilot plant consisted of clarification,sand-filtration,and ultrafiltration modules in sequence,with a provision to bypass the sand filter.Clean water that conformed to World Health Organization (WHO) guidelines on Potable Quality was reclaimed.Turbidity,aluminum and iron were found to be critical contaminants in process selection and design.Clarification,followed by sand filtration,was found to be the minimum requirement for recycling filter backwash.However,membrane filtration would enhance reclaimed water quality as the membrane acts as an additional barrier against Giardia and Cryptosporidium. | C B Chidambara Raj Tan Ee Kwong Soh Hoo Tiong Paul Stefan Klose | 2008 | Journal of Environmental Sciences2008，20，11： | 4 |
| 8 | Feasibility and accuracy of coronary imaging in elderly patients using the 64-row multi-detector computed tomography: a correlation study with conventional coronary angiography显示文摘Background Elderly patients generally have higher occurrence of coronary calcification, increased heart rate and difficulty with prolonged breath-holding. The aim of our study was to investigate the feasibility and accuracy of using 64-row multi-detector computed tomography (MDCT) in the assessment of coronary artery stenoses in elderly patients. Methods One hundred and fifty two patients with suspected or known coronary artery disease were divided into 4 groups according to their age (Group A: 40-49 years,n=34; Group B: 50-59 years, n=57; Group C: 60-69 years, n=48; Group D: 70 years and above; n=13). Coronary CT angiography (CTA) using a 64-row MDCT was performed and the findings were compared with that of conventional coronary angiography (CCA).Using axial images, multi-planar reconstructions (MPR) and maximum intensity projections (MIP), coronary segments of lumen diameter = 1.5mm were analyzed for the presence of significant stenosis (= 50% ). Results Percentages of poor image quality from coronary CTA preventing reliable correlations with CCA were 21%, 14%, 19% and 62% in Groups A to D respectively. Patients in Group D had significantly higher calcium scores compared with the other groups (P<0.001). In patients where CTA images were of acceptable quality, percentages of accurate correlations with CCA were 89.8%, 93.4%, 86.6% and 78.0% for Groups A to D respectively.There were no significant difference in serum creatinine, heart rate and contrast volume between the 4 groups. Conclusions The 64-row MDCT coronary angiography was less accurate and feasible for patients aged 70 years or above due to heavy coronary calcification and inability to perform a satisfactory breath-hold. However, a high diagnostic accuracy with the MDCT is possible in patients aged less than 70 years. | Chee Khoon LIEW Sze Piaw CHIN Tiong Kiam ONG Seyfarth Tobias Yean Yip FONG Choon Kiat ANG Houng Bang LIEW Rapaee ANNUAR Kui Hian SIM | 2006 | Journal of Geriatric Cardiology2006，3，1： | 4 |
| 9 | Validation of laparoscopy and flexible ureteroscopy tasks in inanimate simulation training models at a large-scale conference setting显示文摘Objective:Simulation based training with training models is being increasingly used as a tool to help trainees mount the learning curve.However,validation studies of surgical simulators are often limited by small numbers.We aim to evaluate the feasibility of validating simulation-training tasks in laparoscopy and flexible ureteroscopy(FURS)rapidly at a large-scale conference setting for residents.Methods:Seventy-six urology residents from various Asian countries were assessed on their laparoscopic and FURS skills during the 14th Urological Association of Asia Congress 2016.Residents performed the peg transfer task from the fundamentals of laparoscopic surgery(FLS)and completed inspection of calyces and stone retrieval using a flexible ureteroscope in an en-dourological model.Each participant’s experience(no experience,1-30 or>30 procedures)in laparoscopy,rigid ureteroscopy(RURS)and FURS was self-reported.Results:Median time taken to complete the laparoscopic task decreased with increasing laparoscopic experience(209 s vs.177 s vs.145 s,p=0.008)whereas median time taken to complete the FURS tasks reduced with increasing FURS experience(405 s vs.250 s vs.163 s,p=0.003)but not with RURS experience(400.5 s vs.397 s vs.331 s,p=0.143),demonstrating construct validity.Positive educational impact of both tasks was high,with mean ratings of 4.16/5 and 4.10/5 respectively,demonstrating face validity.Conclusion:Our study demonstrates construct and face validities of laparoscopy and FURS simulation tasks among residents at a conference setting.Validation studies at a conference setting can be an effective avenue for evaluating simulation models and curriculum in the future. | Jirong Lu Karthik Thandapani Tricia Kuo Ho Yee Tiong | 2021 | Asian Journal of Urology2021，8，2： | 2 |
| 10 | Degradation behavior of poly(caprolactone)-poly(ethylene glycol)block copolymer/low-density polyethylene blends显示文摘 | Tiong SC Bei JZ | 1998 | Polym Engng Sci1998，38，： | 2 |
| 11 | Identification of crystal symmetry from noisy diffraction patterns by a shape analysis and deep learning显示文摘The robust and automated determination of crystal symmetry is of utmost importance in material characterization and analysis.Recent studies have shown that deep learning(DL)methods can effectively reveal the correlations between X-ray or electron-beam diffraction patterns and crystal symmetry.Despite their promise,most of these studies have been limited to identifying relatively few classes into which a target material may be grouped.On the other hand,the DL-based identification of crystal symmetry suffers from a drastic drop in accuracy for problems involving classification into tens or hundreds of symmetry classes(e.g.,up to 230 space groups),severely limiting its practical usage. | Leslie Ching Ow Tiong Jeongrae Kim Sang Soo Han Donghun Kim | 2020 | npj Computational Materials2020，，1： | 2 |
| 12 | ^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy显示文摘Objective: Prostate cancers(PCa) in Asian individuals are molecularly distinct from those found in their Caucasian counterparts.There is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy(Rad P). This study aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography(PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad P.Methods: ^(68)Ga PSMA-PET and CT body with/without bone scan [conventional workup(CWU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by comparison with CWU.Results: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy(HT) and whole pelvis radiotherapy(RT) in addition to bed RT, and 15 to palliative HT alone.Conclusions: In the present report, we demonstrated the diagnostic and treatment decision utility of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels(< 1.0 ng/mL) highlights the role of the tool in assigning patients to treatment intensification with HT-RT or palliative HT in polymetastatic disease. | Janice S.H.Tan Charles X.Y.Goh Yen Sin Koh Youquan Li Jeffrey K.L.Tuan Eu Tiong Chua Terence W.K.Tan Michael L.C.Wang Lui Shiong Lee Kae Jack Tay Ravindran Kanesvaran Chee Keong Toh Aaron K.T.Tong Winnie W.C.Lam Melvin L.K.Chua | 2019 | Cancer Biology & Medicine2019，16，1： | 2 |
| 13 | Mesomorphic behavior of new benzothiazole liquid crystals having Schiff base linker and terminal methyl group显示文摘heterocycles 的一个相应系列, 6-methyl-2-(4-alkoxybenzylidenamino ) benzothiazoles,被综合并且描绘了使用英尺红外, 1H 和 13C NMR 和集体度谱的分析。二形互变的 nematic 阶段为更矮的成员被观察。近晶的 A 阶段仅仅向前从 octyloxy 衍生物出现了。在 benzothiazole 碎片和 Schiff 基础连接的终端甲基组影响了现在的系列的具有由中胚叶发达的行为。 | Sie Tiong Ha Kok Leei Foo Hong Cheu Lin Masato M.Ito Kazuma Abe Kenji Kunbo S.Sreehari Sastry | 2012 | Chinese Chemical Letters2012，23，7： | 2 |
| 14 | Minimum feasible tariff model for BOT water supply projects in Malaysia 显示文摘 | Lianyu C Tiong R | 2005 | Construction Management and Economics2005，23，3： | 1 |
| 15 | Positive Management of differences for risk reduction in BOT projects显示文摘 | Yeo K T Tiong R L K | 2001 | International Journal of Project Management2001，18，4： | 1 |
| 16 | Valuing Equity Indexed Annuities 显示文摘 | TIONG S | 2000 | North American Actuarial Journal2000，4，4： | 1 |
| 17 | Corro- sion treatments and the fatigue of aerospace structural joints显示文摘 | Jaya A Tiong U H Reza Mohammed R | 2010 | Procedia Engineering2010，，2： | 1 |
| 18 | Laparoscopic repair of vesicovaginal fistula显示文摘 | Tiong HY Shim T Lee YM | | 0，，04： | 1 |
| 19 | Case Study of Government Initiatives for PRC's BOT Power Plant Project显示文摘 | TIONG L K | 2000 | International Journal of Project Management2000，18，1： | 1 |
| 20 | Nomograms for predict-ing graft function and survival in living donor kidney transplantation based on the UNOS Registry显示文摘 | Tiong HY Goldfarb DA Kattan MW | 2009 | J Urol2009，181，3： | 1 |
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