|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Immunological response in alcoholic liver disease显示文摘The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD. | Michael J Duryee Lynell W Klassen Geoffrey M Thiele | 2007 | World Journal of Gastroenterology2007，13，37： | 9 |
| 3 | 2008WHO骨髓增殖性肿瘤及骨髓增生异常综合征分型显示文摘2008年WHO骨髓增殖性肿瘤(MPN)/骨髓增生异常综合征(MDS)分型共分成4大类,每类又分多种不同疾病. | Vardiman J W Thiele J Arber DA 俞文娟(节译) 金洁(审校) | 2010 | 国际输血及血液学杂志2010，，3： | 3 |
| 4 | Which Time-to-Peak Threshold Best Identifies Penumbral Flow?: A Comparison of Perfusion-Weighted Magnetic Resonance Imaging and Positron Emission Tomography in Acute Ischemic Stroke显示文摘 | J Sobesky O Zaro Weber F -G. Lehnhardt V Hesselmann A Thiel C Dohmen A Jacobs M Neveling W -D. Heiss | 2004 | Stroke2004，，12： | 2 |
| 5 | Molecular signals for anaerobic methane oxidation in Black Sea seep carbonates and a microbial mat 显示文摘 | Thiel V Peckmann J Richnow H H Luth U Reitner J Michaelis W Peckmann J | 2001 | Mar Chem2001，73，2： | 1 |
| 6 | Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease显示文摘 | Boger RH Bode-Boger SM Thiele W | 1998 | J Am Coll Cardiol1998，32，5： | 1 |
| 7 | Corneal complicationsin Goldenhar-Gorlin syndrome 显示文摘 | Weidle EG Thiel HJ Lisoh W | 1987 | Klin Monbl Augenheilkd1987，190，5： | 1 |
| 8 | Transmissionof cytomegalovirus (CMV) infection by leukoreducedblood products not tested for CMV antibodies: a single-center prospective study in high-risk patients undergoingallogeneic hematopoietic stem cell transplantation (CME)显示文摘 | Thiele T Kruger W Zimmermann K | 2011 | Transfusion2011，51，12： | 1 |
| 9 | The anharmonic force fields of HOF and F2O显示文摘 | Thiel W Scuseria G Allen W D | 1988 | J Chem Phys1988，89，8： | 1 |
| 10 | Liquid chromatographic determination of Fumonisins B1,B2, and B3 in foods and feeds显示文摘 | Eric W Sydenham Gordon S Shephard Pieter G Thiel | 1992 | Mycotoxins1992，75，： | 1 |
| 11 | The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia:rationale and important changes显示文摘 | Vardiman J W Thiele J Arber D A | 2009 | Blood2009，114，5： | 1 |
| 12 | Shock wave therapy for acute and chronic soft tissue wounds : a feasibility study 显示文摘 | Schaden W Thiele R KSlpl C | 2007 | J Surg Res2007，143，1： | 1 |
| 13 | Discovery of a novel tumour metastasis-promoting gene, NVM-1 显示文摘 | Thiele W Novac N Mink S | 2011 | J Pathol2011，225，： | 1 |
| 14 | Primary central nervous system lymphomas(PCNSL):MRI response criteria revised显示文摘 | Küker W N?gele T Thiel E | | 0，，07： | 1 |
| 15 | H epatitisB and C in pregnancy: a review and recom m endations forcare显示文摘 | D unkelberg JC Berkley E M Thiel K W | 2014 | J P erinatol2014，34，12： | 1 |
| 16 | Anharmonic force fields from density functional theory 显示文摘 | Dressier S Thiel W | 1997 | Chem Phys Lett1997，273，12： | 1 |
| 17 | Copper-specific transcriptional repression of yeast genes encoding crit-ieal components in the copper transport pathway显示文摘 | Labbe S Zhu H W Thiele D J | 1997 | J Biol Chem1997，272，15： | 1 |
| 18 | Relation between catalytic activity and sizeof particle 显示文摘 | Thiele E W | 1939 | Industrial & Engineering Chemistry1939，31，7： | 1 |
| 19 | Anharmonic force fields from analytic second derivatives:Method and application to methyl bromide 显示文摘 | Schneider W Thiel W | 1989 | Chem Phys Lett1989，157，4： | 1 |
| 20 | Tumor metastasis and the lymphatic vasculature显示文摘 | SLEEMAN JP THIELE W | 2009 | Int J Cancer2009，125，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员