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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype. | Kristina Roessler Stefan P.M(o|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 3 | Which Time-to-Peak Threshold Best Identifies Penumbral Flow?: A Comparison of Perfusion-Weighted Magnetic Resonance Imaging and Positron Emission Tomography in Acute Ischemic Stroke显示文摘 | J Sobesky O Zaro Weber F -G. Lehnhardt V Hesselmann A Thiel C Dohmen A Jacobs M Neveling W -D. Heiss | 2004 | Stroke2004，，12： | 2 |
| 4 | The incidence, timing, and management of biliary tract complications after orthotopic liver transplantation显示文摘 | GREIF F BRONTHER O THIEL DH | 1994 | Annals of Surgery1994，219，： | 1 |
| 5 | The status of the Tropical Rainfall Measuring Mission (TRMM) after two years in orbit显示文摘 | KUMMEROW C SIMPSON J THIELE O | 2000 | J Appl Meteor2000，39，12： | 1 |
| 6 | Interplay between pro- moter and structural gene variants control basal serum level of man- nan - binding protein 显示文摘 | MADSEN H O GARRED P THIEL S | 1995 | J Immunol1995，155，6： | 1 |
| 7 | Fusarium moniliforme and fumonisins in corn in relation to human oesophageal cancer in Transkei显示文摘 | Rheeder J P Marasas W F O Thiel P G Sydenham E W Shephard G S Van Schalkwyk D J | 1992 | Phytopathology1992，82，： | 1 |
| 8 | Fusarium Moniliforme and Fumonisins in Corn in Relation to Human Esophageal Cancer in Transkei显示文摘 | Rheeder J P Marasas W F O Thiel P G | 1992 | Phytopathology1992，82，： | 1 |
| 9 | Practical synthesis of a vanilloid receptor-1 antagonist显示文摘 | Thiel O R Bernard C King T | 2008 | J Org Chem2008，73，9： | 1 |
| 10 | The cloning and expression of a gene encoding Old Yellow Enzyme from Saccharomyces carlsbergensis 显示文摘 | Saito K Thiele DJ Davio M Lockridge O Massey V | 1991 | J Biol Chem1991，266，20： | 1 |
| 11 | Natural occur-rence of some Fusarium mycotoxins in cornfrom low and high esophageal cancer prevalence areas of the Transkei,southern Africa显示文摘 | Sydenham E W Thiel P G Marasas W F O | | 0，，10： | 1 |
| 12 | The incidence, timing, and management of biliary tract complications after orthotopic liver transplantation显示文摘 | Greif F Bronsther O Thiel DHV | 1994 | Ann Surg1994，219，1： | 1 |
| 13 | Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentration 显示文摘 | Garred P Thiel S Madsen H O | 1992 | Clin Exp Immunol1992，90，3： | 1 |
| 14 | A protocol for generating a high-quality genomescale metabolic reconstruction 显示文摘 | Thiele I Palsson B O | 2010 | Nature protocols2010，5，： | 1 |
| 15 | MAp19,the alternative spliceproduct of the MASP2gene显示文摘 | Degn S E Thiel S Nielsen O | 2011 | J Immunol Methods2011，373，12： | 1 |
| 16 | Grading and therapy monitoring of astrocytomas with ^1H-spectroscopy:preliminary study显示文摘 | Speck O Thiel T Hennig J | 1996 | Anticancer Res1996，16，3： | 1 |
| 17 | Analysis of ferrite beads for RF isolation on straight wire conductors显示文摘 | Saario S A Thiel D V O'Keefe S G | 1997 | Electronics Letters1997，33，16： | 1 |
| 18 | Interplay between promoter and structural gene variants control basal senun level of mannan-binding protein显示文摘 | Garred P Thiel S | 1995 | J Immunol1995，155，： | 1 |
| 19 | A novel keratin 12 mutation in a German kindred with Meesmann's corneal dystrophy显示文摘 | Corden LD Swensson O Swensson B Rochels R Wannke B Thiel HJ | 2000 | Br J Ophthalmol2000，84，： | 1 |
| 20 | Dimethylsulfoniopropionate (DMSP) in ieealgae and its possible biological role显示文摘 | KIRST G O THIEL C WOLFF H et ai | 1991 | Marine Chemistry1991，35，1： | 1 |
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