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| 1 | Role of inflammation and infection in the pathogenesis of human acute liver failure: clinical implications for monitoring and therapy显示文摘Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multiorgan failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research. | Mhairi C Donnelly Peter C Hayes Kenneth J Simpson | 2016 | World Journal of Gastroenterology2016，22，26： | 13 |
| 2 | 影响林木种子贮藏的因素(英文)显示文摘为了每年提供造林新需的具有生活力的种子及长期保存种质资源,贮藏种子是必要的手段。种子寿命具有遗传性,且因树种而异。种子的贮藏特性可以分成5类:正常型、亚正常型、温带顽拗型、热带顽拗型和中间型。种子含水量和贮藏温度是影响种子贮藏是否成功的两个最重要因素。但因树种及其贮藏特性不同,种子含水量和贮藏温度的最适值也不同。为了保持正常型和亚正常型种子的生活力,这类种子必须密封贮藏;但对顽拗型种子,因其需要保持种子的代谢活性及要进行有氧呼吸,则需要气体交换。 | Ben S P Wang J Dale Simpson | 2006 | 南京林业大学学报(自然科学版)2006，30，1： | 8 |
| 3 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 4 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 5 | HMB-45在普通型子宫平滑肌肉瘤中的表达显示文摘 | Simpson K W Albores-Saavedra J 付长霞(摘译) 张仁亚(审校) | 2007 | 临床与实验病理学杂志2007，23，3： | 5 |
| 6 | 胰腺实性-假乳头状肿瘤透明细胞变异型显示文摘 | Albores-Saavedra J Simpson K W Bilello S J 潘敏鸿(摘译) 饶秋(摘译) 周晓军(审校) | 2006 | 临床与实验病理学杂志2006，22，6： | 5 |
| 7 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 8 | Pediatric obesity prevention:From na?ve examination of energy imbalance towards strategies that influence the competition for nutrient resources among tissues显示文摘Current pediatric obesity interventions have collectively yielded relatively unsuccessful results. In this Field of Vision, we present plausible physiologic underpinnings fostering ineffectiveness of conventional strategies grounded in requisite induction of negative energy imbalance. Moreover, such recommendations exacerbate the underlying metabolic dysfunction by further limiting metabolic fuel availability, lowering energy expenditure, and increasing hunger(recapitulating the starvation response amid apparent nutritional adequacy) which precede and promote obesity during growth and development. The qualitative aspects of musculoskeletal system(i.e., endocrine response, muscle functional capacity) are likely to improve metabolic function and increase nutrient delivery and utilization. An intricate and complex system including multiple feedback mechanisms operates to homeostatically regulate energy balance and support optimal body composition trajectories and metabolic health, during growth and development. Thus, ignoring the interdependencies of regulatory growth processes initiates a nuanced understanding of energy regulation and thus misguided attempts at preventive strategies. Importantly, these gains are not dependent upon weight-loss, rather we suggest can be achieved through resistance training. Collectively, optimizing musculoskeletal health via resistance training elicits augmentation of competitive capacity across systems. Further, substantial gains can be achieved in skeletal muscle mass, strength, and functional capacity through resistance training in a relatively short period of time. | Lynae J Hanks Tina Simpson Kenneth McCormick Krista Casazza | 2015 | World Journal of Clinical Pediatrics2015，4，4： | 2 |
| 9 | Electrospinning of collagen nanofibers 显示文摘 | Matthews J A Wnek G E Simpson D G | 2002 | Biomacromolecules2002，3，2： | 1 |
| 10 | Survival of acute myeloid leukemia ceils requires PI3 kinase activation 显示文摘 | XU Q SIMPSON S E SCIALLA T J | 2003 | Blood2003，102，3： | 1 |
| 11 | Satellite detection of natural hydrocarbon seepage: Palm Valley gas field, Amadeus Basin, Central Australia显示文摘 | Simpson C J Wilford J R Macials L F | 1989 | The APEA Journal1989，29，： | 1 |
| 12 | Developments in unsteady pipe flow friction modeling 显示文摘 | BERGANT A SIMPSON A R VITKOVSKY J P | 2001 | J Hydraul Res2001，39，3： | 1 |
| 13 | The cancer/testis genes:review,standardization,and commentary显示文摘 | Simpson A J Old L J | 2004 | Cancer Immunity2004，4，： | 1 |
| 14 | Squamus cell carcinoma of the thyroid gland显示文摘 | Simpson WJ Garruthers J | 1988 | Am J Surg1988，156，1： | 1 |
| 15 | Landscape structure and locust swarming: a satellite's eye view显示文摘 | Despland E Rosenberg Simpson S J | 2004 | Ecography2004，27，3： | 1 |
| 16 | Leak detection and calibration using transients and genetic algorithms显示文摘 | Vitkovsky J P Simpson A R Martin F L | 2000 | Journal Water Resource Planning and Management2000，126，4： | 1 |
| 17 | Sampling strategies for computer experiments design and analysis 显示文摘 | SIMPSON T W LINK J CHEN W | 2001 | International Journal of Reliability and Applications2001，2，3： | 1 |
| 18 | Product family design and platform-based product development: a state-of-the-art review 显示文摘 | Jiao J Simpson T W Siddique Z | 2007 | Journal of Intelligent Manufacturing2007，18，1： | 1 |
| 19 | Product platform design: Method and application 显示文摘 | Simpson T W Maier J R A Mistree F | 2001 | Research in Engineering Design2001，13，1： | 1 |
| 20 | The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene显示文摘 | LI J SIMPSON L TAKAHASHI M | 1998 | Cancer Res1998，58，29： | 1 |
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