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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | Growth of Large-Area Single- and Bi-Layer Graphene by Controlled Carbon Precipitation on Polycrystalline Ni Surfaces显示文摘We report graphene films composed mostly of one or two layers of graphene grown by controlled carbon precipitation on the surface of polycrystalline Ni thin films during atmospheric chemical vapor deposition(CVD).Controlling both the methane concentration during CVD and the substrate cooling rate during graphene growth can signifi cantly improve the thickness uniformity.As a result,one-or two-layer graphene regions occupy up to 87%of the fi lm area.Single layer coverage accounts for 5%11%of the overall fi lm.These regions expand across multiple grain boundaries of the underlying polycrystalline Ni fi lm.The number density of sites with multilayer graphene/graphite(>2 layers)is reduced as the cooling rate decreases.These fi lms can also be transferred to other substrates and their sizes are only limited by the sizes of the Ni fi lm and the CVD chamber.Here,we demonstrate the formation of fi lms as large as 1 in^(2).These fi ndings represent an important step towards the fabrication of large-scale high-quality graphene samples. | Alfonso Reina Stefan Thiele Xiaoting Jia Sreekar Bhaviripudi Mildred S.Dresselhaus Juergen A.Schaefer Jing Kong | 2009 | Nano Research2009，2，6： | 21 |
| 3 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 4 | Co-expression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis显示文摘AIM: To evaluate the role of CDX2 homeobox protein as a predictor for cancer progression and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important regulator of intestinal differentiation, which could previously be identified in gastric carcinomas and intestinal metaplasia.METHODS: Formalin-fixed and paraffin-embedded tissues from 190 gastric carcinoma patients were stained with monodonal antibodies recognizing CDX2 and MUC2, respectively. Immunoreactivity was evaluated semiquantitatively and statistical analyses including χ2 tests, uni- and multi-variate survival analyses were performed.RESULTS: CDX2 was mostly expressed in a nuclear or supranuclear pattern, whereas MUC2 showed an almost exclusive supranuclear reactivity. Both antigens were present in >80% of areas exhibiting intestinal metaplasia. An immunoreactivity in >5% of the tumor area was observed in 57% (CDX2) or in 21% (MUC2) of the carcinomas. The presence of both molecules did not correlate with WHO,significantly stronger vlUC2 expression in mucinous tumors). CDX2 correlated with a lower pT and pN stage in the subgroups of intestinal and stage I cancers and was associated with MUC2 positivity. A prognostic impact of CDX2 or MUC2 was not observed. CONCLUSION: CDX2 and MUC2 play an important role in the differentiation of normal, inflamed, and neoplastic gastric tissues. According to our results, loss of CDX2 may represent a marker of tumor progression in early gastric cancer and carcinomas with an intestinal phenotype. | Kristina Roessler Stefan P.M(o|¨)nig Paul M.Schneider Franz-Georg Hanisch Stephanie Landsberg Juergen Thiele Arnulf H.H(o|¨)lscher Hans P.Dienes Stephan E.Baldus | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 5 | Cirrhotic ascites review: Pathophysiology, diagnosis and management显示文摘Ascites is a pathologic accumulation of peritoneal fluidcommonly observed in decompensated cirrhotic states. Its causes are multi-factorial, but principally involve significant volume and hormonal dysregulation in the setting of portal hypertension. The diagnosis of ascites is considered in cirrhotic patients given a constellation of clinical and laboratory findings, and ultimately confirmed, with insight into etiology, by imaging and paracentesis procedures. Treatment for ascites is multimodal including dietary sodium restriction, pharmacologic therapies, diagnostic and therapeutic paracentesis, and in certain cases transjugular intra-hepatic portosystemic shunt. Ascites is associated with numerous complications including spontaneous bacterial peritonitis, hepato-hydrothorax and hepatorenal syndrome. Given the complex nature of ascites and associatedcomplications, it is not surprising that it heralds increased morbidity and mortality in cirrhotic patients and increased cost-utilization upon the health-care system. This review will detail the pathophysiology of cirrhotic ascites, common complications derived from it, and pertinent treatment modalities. | Christopher M Moore David H Van Thiel | 2013 | World Journal of Hepatology2013，5，5： | 13 |
| 6 | Immunological response in alcoholic liver disease显示文摘The development of alcoholic liver disease (ALD) can be attributed to many factors that cause damage to the liver and alter its functions. Data collected over the last 30 years strongly suggests that an immune component may be involved in the onset of this disease. This is best evidenced by the detection of circulating autoantibodies, infiltration of immune cells in the liver, and the detection of hepatic aldehyde modified proteins in patients with ALD. Experimentally, there are numerous immune responses that occur when proteins are modified with the metabolites of ethanol. These products are formed in response to the high oxidative state of the liver during ethanol metabolism, causing the release of many inflammatory processes and potential of necrosis or apoptosis of liver cells. Should cellular proteins become modified with these reactive alcohol metabolites and be recognized by the immune system, then immune responses may be initiated. Therefore, it was the purpose of this article to shed some insight into how the immune system is involved in the development and/or progression of ALD. | Michael J Duryee Lynell W Klassen Geoffrey M Thiele | 2007 | World Journal of Gastroenterology2007，13，37： | 9 |
| 7 | Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use显示文摘Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via endoscopes.Miniaturized endoscopic probes are necessary for imaging small luminal or delicate organs without causing trauma to tissue.However,current fabrication methods limit the imaging performance of highly miniaturized probes,restricting their widespread application.To overcome this limitation,we developed a novel ultrathin probe fabrication technique that utilizes 3D microprinting to reliably create side-facing freeform micro-optics(<130μm diameter)on single-mode fibers.Using this technique,we built a fully functional ultrathin aberration-corrected optical coherence tomography probe.This is the smallest freeform 3D imaging probe yet reported,with a diameter of 0.457 mm,including the catheter sheath.We demonstrated image quality and mechanical flexibility by imaging atherosclerotic human and mouse arteries.The ability to provide microstructural information with the smallest optical coherence tomography catheter opens a gateway for novel minimally invasive applications in disease. | Jiawen Li Simon Thiele Bryden C.Quirk Rodney W.Kirk Johan W.Verjans Emma Akers Christina A.Bursill Stephen J.Nicholls Alois M.Herkommer Harald Giessen Robert A.McLaughlin | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 8 | Nano-Morphology of a Polymer Electrolyte Fuel Cell Catalyst Layer Imaging, Reconstruction and Analysis显示文摘在聚合物电解质燃料房间(PEFC ) 的阴极催化剂层(CCL ) 的氧减小反应(ORR ) 在操作期间是表演损失的主要原因之一。另外, CCL 由于磅催化剂的使用是最昂贵的部件。除了 ORR 本身,种类运输到并且从反应地点决定 PEFC 的表演。在 CCL 的种类的有效运输性质取决于它的 nanostructure。因此, CCL 的三维的重建被要求。一系列二维的图象从集中的离子横梁扫描被获得为二维的图象的电子显微镜(FIB-SEM ) 成像和一个分割方法被开发了。毛孔尺寸分发(PSD ) 为三维的几何学被计算。PSD 上的排列和各向异性的象素尺寸的影响被调查了。毛孔在在 5 nm 和 205 nm 之间的范围被发现。Knudsen 数字的评估证明在 CCL 的那煤气的运输被转变流动政体管理。液体水运输能被包括在连续统水动力学以内描述合适滑动流动边界条件。 | Simon Thiele Roland Zengerle Christoph Ziegler | 2011 | Nano Research2011，4，9： | 5 |
| 9 | 聚酯回收应用现状显示文摘聚酯回收利用一直是个备受关注的话题。20世纪70年代,随着聚酯瓶的问世,工业聚酯废料就开始了回收利用。北爱尔兰的Wellman公司是最早开始聚酯回收利用的企业。到了20世纪90年代,随着聚酯苏打水瓶的出现,急速增长的塑料垃圾开始成为令人们头痛的问题。但正是这一问题有效促进了回收利用技术的发展。 | U. Thiele 柳宝琴(译) 李毓陵(校) | 2012 | 国际纺织导报2012，40，11： | 5 |
| 10 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 11 | How do altitude and soil properties influence the taxonomic and phylogenetic structure and diversity of Brazilian páramo vegetation?显示文摘Altitude and environmental variables such as edaphic properties are considered determinants of species distribution and community composition in mountain ecosystems.Here,we aimed to outline the effects of distinct mountain peaks,altitude and soil properties on community composition,species density,phylogenetic structure and diversity of angiosperm páramo communities from the Serra do Brigadeiro State Park,Minas Gerais,southeastern Brazil.For that,we identified all angiosperm species found in 300 plots(1 m×1 m)from three mountain peaks,measured soil depth and analyzed soil fertility and texture in each plot.To reduce the number of soil variables and species composition,we computed principal coordinates based on soil properties and principal coordinates based on species-plot matrix for each plot.Furthermore,we computed the standard effect sizes of the mean phylogenetic pairwise distance and the mean nearest phylogenetic taxon distance for each plot to investigate differences in the degree of relatedness among coexisting species.We compared differences in response variables between peaks and modelled them in function of altitude and principle components of soil properties using mixed effect models.Species density and phylogenetic diversity differed between peaks,but,contrary to the previous findings,no relationships between species richness or phylogenetic diversity and altitude or soil properties were found,indicating that further investigations are necessary to understand the altitude-biodiversity relationship in Brazilian páramo vegetation.Community composition differed between peaks and depended on altitude,soil properties and interactions between them,indicating that upward shifting of bioclimatic conditions due to climate changes may alter communities of this ecosystem.Phylogenetic structure differed between peaks and was influenced by altitude and soil properties.As phylogenetic clustering increased with altitude,eventual upward movements of species in Brazilian páramo vegetation due to climate change may alter community composition and the degree of relatedness among coexisting species,increasing the risk of species from higher altitudes to disappear.Therefore,conservation priorities arise for higher landscape portions,where these high altitude species may find refuges. | Markus GASTAUER Jan THIELE Stefan POREMBSKI Andreza Viana NERI | 2020 | Journal of Mountain Science2020，17，5： | 4 |
| 12 | Using resistance distance from circuit theory to model dispersal through habitat corridors显示文摘Aims Resistance distance(RD),based on circuit theory,is a promising metric for modelling effects of landscape configuration on dispersal of organ-isms and the resulting population and community patterns.The values of RD reflect the likelihood of a random walker to reach from a source to a certain destination in the landscape.Although it has successfully been used to model genetic structures of animal populations,where it most often outperforms other isolation metrics,there are hardly any applications to plants and,in particular,to plant community data.Our aims were to test if RD was a suitable metric for studying dispersal processes of plants in narrow habitat corridors(linear landscape ele-ments[LLE]).This would be the case,if dispersal processes(seed dis-persal and migration)resembled random walks.Further,we compared the model performance of RD against least-cost distance(LCD)and Euclidean distance(ED).Finally,we tested the suitability of different cost surfaces for calculations of LCD and RD.Methods We used data from 50 vegetation plots located on semi-natural LLE(field margins,ditches,road verges)in eight agricultural landscapes of Northwest Germany.We mapped LLE,including hedges and tree rows,from aerial images in a Geographic Information System,con-verted the maps into raster layers,and assigned resistance values to the raster cells,where all cells outside of LLE received infinite resist-ance and,thus,represented barriers to dispersal.For all pairs of plots within study areas,we calculated Jaccard similarity assuming that it was a proxy(or correlate)of dispersal events between plots.Further,we calculated RD and LCD of the network of LLE and ED between the plots.We modelled the effects of distance metrics on community similarity using binomial generalized linear mixed models.Important Findings ED was clearly the least suitable isolation metrics.Further,we found that RD performed better than LCD at modelling Jaccard similar-ity.Predictions varied markedly between the two distance metrics suggesting that RD comprises additional information about the landscape beyond spatial distance,such as the possible presence of multiple pathways between plots.Cost surfaces with equal cell-level resistances for all types of LLE performed better than more complex ones with habitat-specific resistances.We conclude that RD is a highly suitable measure of isolation or,inversely,connec-tivity for studying dispersal processes of plants within habitat cor-ridors.It is likely also suitable for assessing landscape permeability in other landscape types with areal habitats instead of narrow cor-ridors.RD holds the potential to improve assessments of isolation(or connectivity)for models of regional population and meta-com-munity dynamics. | Jan Thiele Sascha Buchholz Jens Schirmel | 2018 | Journal of Plant Ecology2018，11，3： | 3 |
| 13 | Exploiting EST databases for the development and characterization of gene-derived SSR-markers in barley (Hordeum vulgare L.)显示文摘 | T. Thiel W. Michalek R. Varshney A. Graner | 2003 | Theoretical and Applied Genetics2003，，3： | 3 |
| 14 | 基于非交错有限体积格式和 k-ω 湍流模型模拟叶栅湍流分离流动显示文摘发展了一种求解任意坐标系下二维N-S方程的非交错有限体积法和一种高阶TVD对流格式。采用一种k-ω湍流模型和几种不同的k-ω模型对叶栅湍流分离流动进行了详细的分析。数值结果与得到的实验结果比较表明,此方法不仅精度高,而且具有较好的数值稳定性。 | 吴虎 Thiele F | 1998 | 推进技术1998，19，4： | 3 |
| 15 | Recent advances in the treatment of post-stroke aphasia显示文摘Aphasia is an impairment of language use following brain damage There is no consensual definition of aphasia beyond this general description(Code and Petheram,2011).In a more restricted definition,however,aphasia is an impairment of linguistic processing at the phonological,morphological,lexical semantic or syntactic level which is usually caused by lesions of the left cerebral hemisphere This impairment can affect language reception and | Anna Zumbansen Alexander Thiel | 2014 | Neural Regeneration Research2014，9，7： | 3 |
| 16 | Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss显示文摘High erythropoietin(Epo)levels are detrimental to bone health in adult organisms.Adult mice receiving high doses of Epo lose bone mass due to suppressed bone formation and increased bone resorption.In humans,high serum Epo levels are linked to fractures in elderly men.Our earlier studies indicated that Epo modulates osteoblast activity;however,direct evidence that Epo acts via its receptor(EpoR)on osteoblasts in vivo is still missing.Here,we created mice lacking EpoR in osteoprogenitor cells to specifically address this gap.Deletion of EpoR in osteoprogenitors(EpoR:Osx-cre,cKO)starting at 5 weeks of age did not alter red blood cell parameters but increased vertebral bone volume by 25%in 12-week-old female mice.This was associated with low bone turnover.Histological(osteoblast number,bone formation rate)and serum(P1NP,osteocalcin)bone formation parameters were all reduced,as were the number of osteoclasts and TRAP serum level.Differentiation of osteoblast precursors isolated from cKO versus control mice resulted in lower expression of osteoblast marker genes including Runx2,Alp,and Col1a1 on day 21,whereas the mineralization capacity was similar.Moreover,the RANKL70PG ratio,which determines the osteoclast-supporting potential of osteoblasts,was substantially decreased by 50%.Similarly,coculturing cKO osteoblasts with control or cKO osteoclast precursors produced significantly fewer osteoclasts than coculture with control osteoblasts.Finally,exposing female mice to Epo pumps(10 U-d_1)for 4 weeks resulted in trabecular bone loss(-25%)and increased osteoclast numbers(1.7-fold)in control mice only,not in cKO mice.Our data show that EpoR in osteoprogenitors is essential in regulating osteoblast function and osteoblast-mediated osteoclastogenesis via the RANKI70PG axis.Thus,osteogenic Epo/EpoR signaling controls bone mass maintenance and contributes to Epo-induced bone loss. | Martina Rauner Marta Murray Sylvia Thiele Deepika Watts Drorit Neumann Yankel Gabet Lorenz C.Hofbauer Ben Wielockx | 2021 | Bone Research2021，9，4： | 3 |
| 17 | Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics显示文摘AIM:To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis(SBP). METHODS: A total of 57 consecutive patients with ascites requiring a large volume paracentesis were studied. Their age, gender, specific underlying disease conditions were recorded after a review of their clinical records. Each underwent a routine assessment prior to their paracentesis consisting of a complete blood count, complete metabolic profile and prothrombin time/international normalized ratio(INR) determination. The ascitic fluid was cultured and a complete cellcount and albumin determination was obtained on the fluid. In addition, blood and ascitic fluid was assessed for the levels of interleukin interleukin(IL)-1A, IL-1B, IL-2, IL-4, IL-8, IL-10, monocyte chemotactic protein(MCP)-1, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) utilizing the Randox Biochip platforms(Boston, MA). A serum-ascites gradient, for each cytokine and growth factor was calculated. The results are reported as mean ± SEM between disease groups with statistical analysis consisting of the student t-test(two tailed) with a P value of 0.05 defining significance. RESULTS: No clinically important demographic or biochemical differences between the 4 groups studied were evident. In contrast, marked difference in the cytokine and growth factors levels and pattern were evident between the 4 disease groups. Individuals with alcoholic cirrhosis had the highest levels of IL-1A, IL-1B, IL-4, IFNγ. Those with malignant disease had the highest levels of IL-2. Those with hepatitis C virus(HCV) associated cirrhosis had the highest value for IL-6, IL-8, IL-10, MCP-1 and VEGF. Those with cardiac disease had the highest level of TNF-α and EGF. The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of IL-8, IL-10 and MCP-1 in ascites than did those with alcohol or HCV disease. CONCLUSION: These data document important differences in the cytokine and growth factor levels in plasma, ascitic fluid and the calculated plasma- ascites fluid gradients in cirrhotics requiring a large volume paracentesis. These differences may be important in determining the risk for bacterial peritonitis. | Bashar M Attar Magdalena George Nicolae Ion-Nedelcu Guilliano Ramadori David H Van Thiel | 2014 | World Journal of Hepatology2014，6，2： | 3 |
| 18 | 2008WHO骨髓增殖性肿瘤及骨髓增生异常综合征分型显示文摘2008年WHO骨髓增殖性肿瘤(MPN)/骨髓增生异常综合征(MDS)分型共分成4大类,每类又分多种不同疾病. | Vardiman J W Thiele J Arber DA 俞文娟(节译) 金洁(审校) | 2010 | 国际输血及血液学杂志2010，，3： | 3 |
| 19 | Serum markers detect the presence of liver fibrosis: A cohort study显示文摘 | William M.C. Rosenberg Michael Voelker Robert Thiel Michael Becka Alastair Burt Detlef Schuppan Stefan Hubscher Tania Roskams Massimo Pinzani Michael J.P. Arthur | 2004 | Gastroenterology2004，，6： | 2 |
| 20 | Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction显示文摘 | Ingo Eitel Volker Adams Patrick Dieterich Georg Fuernau Suzanne de Waha Steffen Desch Gerhard Schuler Holger Thiele | 2012 | American Heart Journal2012，，： | 2 |
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