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| 1 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 2 | Transcriptome analysis of near-isogenic lines provides molecular insights into starch biosynthesis in maize kernel显示文摘Starch is the major component in maize kernels,providing a stable carbohydrate source for humans and livestock as well as raw material for the biofuel industry.Increasing maize kernel starch content will help meet industry demands and has the potential to increase overall yields.We developed a pair of maize near-isogenic lines(NILs) with different alleles for a starch quantitative trait locus on chromosome 3(q HS3), resulting in different kernel starch content. To investigate the candidate genes for q HS3 and elucidate their effects on starch metabolism, RNA-Seq was performed for the developing kernels of the NILs at 14 and 21 d after pollination(DAP). Analysis of genomic and transcriptomic data identified 76 genes with nonsynonymous single nucleotide polymorphisms and 384 differentially expressed genes(DEGs) in the in trogressed fragment, including a hexokinase gene, Zm HXK3 a, which catalyzes the conversion of glucose to glucose-6-phosphate and may play a key role instarch metabolism. The expression pattern of all DEGs in starch metabolism shows that altered expression of the candidate genes for q HS3 promoted starch synthesis,with positive consequences for kernel starch content. These results expand the current understanding of starch biosynthesis and accumulation in maize kernels and provide potential candidate genes to increase starch content. | Yingni Xiao Shawn Thatcher Min Wang Tingting Wang Mary Beatty Gina Zastrow-Hayes Lin Li Jiansheng Li Bailin Li Xiaohong Yang | 2016 | Journal of Integrative Plant Biology2016，58，8： | 2 |
| 3 | 二甲双胍治疗多囊卵巢综合征不孕患者的妊娠结局显示文摘Objective: To analyze pregnancy complications and outcome in patients with polycystic ovary syndrome (PCOS) treated with metformin.Design: Single center retrospective case analysis.Setting: Private regional nonurban referral subspecialty practice.Patient(s): After 7 months of average metformin use, 188 patients with PCOS (average infertility: 27 months) achieved 237 pregnancies.Intervention(s): Of pregnancies established, metformin alone was used before conception in 124/237 (52% ), oral fertility agents (CC or letrozole) in 81 (34% ), gonadotropin therapy in 7 (3.0% ), assisted reproduction in 17 (7.2% ), and other fertility- promoting regimens in 8 (3.4% ).Main Outcome Measure(s): Analysis of prepregnancy health parameters (weight, blood pressure, glucose tolerance, fasting and stimulated insulin levels) and pregnancy outcomes (miscarriage, pregnancy length, hypertension, gestational diabetes, weight gain, birth weight, sex ratio, congenital malformations, and breastfeeding success).Result(s): Metformin appears to decrease the rate of spontaneous abortion.The co-morbidities of PCOS including obesity, insulin resistance, and glucose sensitivity served as indicators of increased risk for pregnancy complications, especially gestational diabetes.No increase in pregnancy- induced hypertension was evident.Prematurity was increased. Neither PCOS nor metformin use appears to increase the rate of congenital anomaly.PCOS did not affect lactation. Conclusion(s): PCOS or its co-morbidities are associated with poorer pregnancy outcome.Implications and interventions are discussed. | Thatcher S. S. Jackson E. M. 朱亮(译) 党慧敏(校) | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，9： | 2 |
| 4 | Moving Beyond Intentions and To- ward the Theory of Trying: Effects of Work Environment and Gender on Post- Adoption Information Technology Use显示文摘 | Ahuja M K Thatcher J B | 2005 | MIS Quarterly2005，29，3： | 1 |
| 5 | Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fbrosis显示文摘 | van Rooij E Sutherland LB Thatcher JE | 2008 | Proc Natl Acad Sci USA2008，105，13： | 1 |
| 6 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomized, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | 2005 | Lancet2005，366，9496： | 1 |
| 7 | Moving beyond intentions and to-ward the theory of trying: Effects of work environment and gender onpost - adoption information technology use 显示文摘 | AHUJA M K THATCHER J B | 2005 | MIS Quarterly2005，29，3： | 1 |
| 8 | The impact of technology invest- ments on a firm's production efficiency, product quality, and pro- ductivity 显示文摘 | THATCHER M E OLIVER J R | 2001 | Journal of Management Information Systems2001，18，2： | 1 |
| 9 | Group faultlines: A review, integration, and guide to future research 显示文摘 | Thatcher S M B Patel P C | 2012 | Journal of Management2012，38，4： | 1 |
| 10 | Genome-wide analysis of alternative splicing during development and drought stress in maize 显示文摘 | Thatcher S R Danilevskaya O N Meng X | 2016 | Plant Physiol2016，170，1： | 1 |
| 11 | A concentration rebound method for measuring particle penetration and deposition in the indoor environment显示文摘 | THATCHER T L LUNDEN M M REVZAN K L | 2003 | Aerosol Science&Technology2003，37，11： | 1 |
| 12 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)显示文摘 | Nick Thatcher Alex Chang Purvish Parikh José Rodrigues Pereira Tudor Ciuleanu Joachim von Pawel Sumitra Thongprasert Eng Huat Tan Kristine Pemberton Venice Archer Kevin Carroll | 2005 | The Lancet . 2005 (9496)2005，，9496： | 1 |
| 13 | Privatization in Brazil显示文摘 | M H Thatcher | 2002 | Brazilian Development2002，4，： | 1 |
| 14 | Reduction of synapsin in the hippocarnpus of patients with bipolar disorder and schizophrenia 显示文摘 | VAWTER M P THATCHER L USEN N | 2002 | Molecular psychiatry2002，7，6： | 1 |
| 15 | Health-Related Quality of life issues in women with Polycystic Ovary Syndrome显示文摘 | MeCook JG Reame NE Thatcher SS | 2005 | J Obstet Gynecol Neonatal Nurs2005，34，1： | 1 |
| 16 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised placebo-controlled, multicentre study (Iressa Survival Evalua tion in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | 2005 | Lancet2005，366，： | 1 |
| 17 | Tectonic contraction across Los Angeles after removal of groundwater pumping effects 显示文摘 | Gerald W Bawden Wayne Thatcher Ross S Stein | 2001 | Nature2001，412，6849： | 1 |
| 18 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer:results from a randomized,placebo-controlled,multicentre study (Iressa Survival Evaluation in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | | 0，，9496： | 1 |
| 19 | Do Workgroup Faultlines Help or Hurt? A Moderated Model of Fault- lines 显示文摘 | Bezrukova K Jehn K A Zanutto E L Thatcher S M B | 2009 | Team Identification and Group Performance Organization Science2009，，1： | 1 |
| 20 | Dysregulation of microRNAs after myocardial infarction reveals a role of miR- 29 in cardiac fibrosis显示文摘 | van Rooij E Sutherland LB Thatcher JE | | Proc0，，13： | 1 |
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