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| 1 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 2 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomized, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | 2005 | Lancet2005，366，9496： | 1 |
| 3 | Solvent free aldol condensation of propanal to 2-methylpentenal using solid base catalysts 显示文摘 | SHARMA S K PARIKH P A JASRA R V | 2007 | Journal of Molecular Catalysis A: Chemical2007，278，12： | 1 |
| 4 | An overview of GaN Growth Chemistry and Its Effect on Reactor Design : Application to a Planetary Radial-flow CVD System显示文摘 | Parikh R P Adomaitis R A | 2006 | Journal of Crystal Growth2006，286，： | 1 |
| 5 | Phase Ⅲ study comparing cisplatin plus gemcitatine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small cell lung cancer 显示文摘 | Scagliotti GV Parikh P Yon Pawel J | 2008 | J Clin Oncol2008，26，21： | 1 |
| 6 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised placebo-controlled, multicentre study (Iressa Survival Evalua tion in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | 2005 | Lancet2005，366，： | 1 |
| 7 | Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer显示文摘 | Scagliotti GV Parikh P von Pawel J | 2008 | J Clin Oncol2008，26，21： | 1 |
| 8 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer:results from a randomized,placebo-controlled,multicentre study (Iressa Survival Evaluation in Lung Cancer)显示文摘 | Thatcher N Chang A Parikh P | | 0，，9496： | 1 |
| 9 | Phase Ⅲ study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage Non-small Cell Lung Cancer显示文摘 | Scagliotti GV Parikh P von Pawel J | 2008 | J Clin Oncol2008，26，21： | 1 |
| 10 | Generation of 3D un-structured grid by the advancing front method显示文摘 | LOHNER R PARIKH P | 1988 | International Journal for Numerical Methods in Fluids1988，8，： | 1 |
| 11 | Phase Ⅲ study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer显示文摘 | Scagliotti GV Parikh P von Pawel J | | 0，，21： | 1 |
| 12 | Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapynaive patients with advanced- stage non-small-cell lung cancer显示文摘 | Seagliotti GV Parikh P Von Pawel J | 2008 | J Clin Oncol2008，26，21： | 1 |
| 13 | Phase Ⅲ study comparing cisplatin plus gemcitabine with cisplatin plus peme trexed in chemotherapy-naiwe patients with advanced-stage non-small-cell lung cancer显示文摘 | Scagliotti GV Parikh P Von Pawel J | 2008 | J Clin Oncol2008，26，： | 1 |
| 14 | Endogenous cell seeding:remnant endothelium after stenting enhances vascular repair显示文摘 | Rogers C Parikh S Seifert P | 1996 | Circulation1996，94，： | 1 |
| 15 | Gefitinib plus best supportive are in previously treated patients with refractory advanced non-small cell lung carcinoma: results from a randomized, placebo-controlled, multicenter study 显示文摘 | Thatcher N Chang A Parikh P | 2005 | Lancet2005，366，： | 1 |
| 16 | Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer显示文摘 | Scagliotti G V Parikh P von P J | 2008 | J Clin Oncol2008，26，21： | 1 |
| 17 | Phase III study compa- ring cisplatin plus gemcitabine with eisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer 显示文摘 | Scagliotti GV Parikh P van Pawel j | 2008 | J Clin 0ncol2008，26，21： | 1 |
| 18 | Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer 显示文摘 | Scagliotti GV Parikh P von Pawel J | 2008 | J Clin Oncol2008，26，21： | 1 |
| 19 | Phase Ⅲ study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer显示文摘 | Scagliotti GV Parikh P yon Pawel J | 2008 | J Clin Oncol2008，26，21： | 1 |
| 20 | Primary intratestieular rhahdomyosareoma in pediatrics显示文摘 | Nasit JG Parikh B Trivedi P | 2013 | Indian J Urol2013，29，1： | 1 |
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