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| 1 | 北京PM_(2.5)化学物种的质量平衡特征显示文摘以北京 2个采样点连续采集的样品对PM2 5中的元素、水溶性离子和含碳组分进行分析 .车公庄和清华园PM2 5中有机物的含量分别为 2 7 8%和 30 9% ,是含量最丰富的物种 ,其次是二次无机粒子、土壤尘、元素碳和微量元素 .PM2 5中约有 2 4 %的质量未能鉴别成分 ,相关性分析表明 ,含碳物种的估算所引起的偏差可能是主要的原因 .采暖期重污染周和春季沙尘周PM2 5的化学物种构成悬殊 ,反映了季节性变化的源排放和特殊气象条件的综合作用 . | 杨复沫 贺克斌 马永亮 张强 Cadle S H Chan T Mulawa P A | 2004 | 环境化学2004，23，3： | 63 |
| 2 | Evolution of systemic therapy of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) commonly occurs in hepatitis B endemic areas, especially in Asian countries. HCC is highly refractory to cytotoxic chemotherapy. This resistance is partly related to its tumor biology, pharmacokinetic properties, and both intrinsic and acquired drug resistance. There is no convincing evidence thus far that systemic chemotherapy improves overall survival in advanced HCC patients. Other systemic approaches, such as hormonal therapy and immunotherapy, have also disappointing results. Recently, encouraging results have been shown in using sorafenib in the treatment of advanced HCC patients. In this review, we concisely summarize the evolution of developments in the systemic therapy of advanced HCC. | Thomas Yau Pierre Chan Richard Epstein Ronnie T Poon | 2008 | World Journal of Gastroenterology2008，14，42： | 23 |
| 3 | The evolution and refinement of vasoepididymostomy techniques显示文摘对 epididymal 阻塞第二等的妨碍的精子缺乏能被 microsurgical 重建与 vasoepididymostomy (VE ) 改正。尽管象与 intracytoplasmic 精子注射一起的 epididymal 或阴囊的精子渴望那样的其他的管理是可行的,各种各样的研究作为选择的治疗建立了 VE 的优异划算。Microsurgical VE 被认为最技术上挑战性的 microsurgeries 之一。它的成功率高度依赖于外科医生的技巧和经验。各种各样的技术为 VE 在文学被描述了。我们开创了作为纵的摄取 VE 知道的一种技术(实时) 在哪个 epididymal 小管被打开获得一个更大的洞允许它的管状的内容通过吻合的纵。我们的初步的数据表明了超过 90 % 的明显率;。这种技术广泛地包括机器帮助 microsurgery 在最近的文学被引用了。不同 VE 的发展的历史来临,与各种各样的 VE 的技术一起的外科手术前的评估将在这篇文章被描述。 | Peter T Chan | 2013 | Asian Journal of Andrology2013，15，1： | 23 |
| 4 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 5 | 绕正方形排列的顺排的四个圆柱的流动研究显示文摘本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡脱落。可是,采用两维有限体积法离散N-S方程计算该流场与实验结果完全不符合,原因尚不清楚。 | 李景银 K Lam K T Chan R M C So | 2004 | 工程热物理学报2004，25，1： | 14 |
| 6 | 基于矩量法的移动荷载识别显示文摘从桥梁响应识别桥面移动荷载往往出现逆问题的病态(不适定性)等共性问题。本文基于移动荷载识别理论,借助矩量法求解积分方程理论并采用整域基函数——正交勒让德多项式表达桥面移动荷载,提出了一种移动荷载识别的时域改进算法。两轴车辆多种组合工况下的常载和时变荷载数值仿真研究表明:与时域法比较,改进时域法识别桥面移动荷载时,其识别精度高、抗噪能力强,识别结果不适定性有显著改善。 | 余岭 朱军华 陈敏中 Chan T H T | 2006 | 振动工程学报2006，19，4： | 9 |
| 7 | 桥梁时变移动车载的间接识别显示文摘针对桥梁上时变移动车载 ,提出了两种桥梁模型、四种移动车载间接识别方法和两种不同解决方案 ,并通过模型实验对上述不同桥梁移动车载解决方案进行验证。仿真和试验结果表明 :虽然各种车桥参数对识别结果都有不同程度的影响 ,但每种解决方案都能有效识别桥梁移动车载且以“时域法”和“频时域法”识别精度较高、实用性较强 ,可推荐用于现场桥梁移动车载识别。 | 余岭 Chan T H T | 2005 | 振动工程学报2005，18，1： | 8 |
| 8 | 基于矩量法的桥梁移动车载识别试验研究显示文摘基于矩量法和移动荷载识别理论,采用整域基函数———正交勒让德多项式表达桥面移动车载,从车致桥梁弯矩响应识别桥面移动车载,提出了一种时域移动荷载识别改进方法(ITDM)。利用试验测量的车致桥梁弯矩响应时程数据重点研究了几个主要参数对ITDM的影响,这些参数包括:基函数数量、模态数、测点数及测点位置和运行时间等,同时与时域法(TDM)进行了对比研究。试验研究结果表明:ITDM性能与TDM相若,但ITDM更以适应性强和省时而优于TDM,这对于桥梁移动荷载的现场在线准确识别非常有利。 | 余岭 朱军华 陈敏中 Chan T H T | 2007 | 振动与冲击2007，26，1： | 8 |
| 9 | The dispersion characteristics of the waves propagating in a spinning single-walled carbon nanotube显示文摘As the nano-motor becomes a mechanical reality, its prototype can be envisaged as nano-sized rotating machinery at a situation,albeit for different purposes, like that in the first half of the 20th century during which rotor dynamics has contributed toboosting machine power capacity. Accordingly, we take the benefit of hindsight to develop a classical framework of vibrationanalysis. Essentially, the equations of motion are formulated to cope with both the special carbon-nanotube properties and thefirst author’s previously developed spinning beam formalism, establishing a model satisfactorily verified by some availablemolecular dynamics (MD) data and classical spinning beam results extracted from the literature. The model is inexpensivebased on continuum mechanics as an alternative to the less-flexible MD method for simulating wave motion of the spinningsingle-walled carbon nanotube, yielding several interesting phenomena, including the fall-off and splitting of the wave charac-teristic curves and the unexpected gyroscopic phase property. Potential applications are proposed. | CHAN K. T ZHAO YaPu | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，10： | 5 |
| 10 | 基于LabVIEW的桥梁健康监测数据采集系统显示文摘桥梁健康监测的第一步是如何实现现场桥梁结构输入输出数据和环境音像资料的精确采集和存储.针对香港新界西青衣南桥的特点,基于LabVIEW软件平台,开发桥梁健康监测数据采集系统,采集并存储桥面运行重车车型、轴数、车速和车辆视频音像资料以及运行重车作用下桥梁的应变和加速度响应时程数据,为桥梁健康监测提供高精度实时原始数据.五昼夜的现场监测结果表明该系统运行正常、桥梁响应数据采集精度高、运行车辆音像资料全面,不失为大型桥梁健康监测采集系统的有益尝试. | 余岭 朱军华 CHAN T H T | 2009 | 暨南大学学报(自然科学与医学版)2009，30，5： | 5 |
| 11 | 堆石体宏细观力学特性演化机制的离散元模拟显示文摘以具有尖角的堆石颗粒材料为研究对象,采用自主开发的多边形离散单元法程序PDEM对其在双轴压缩试验过程中的宏-细观力学特性及变形破坏机制进行系统分析.根据数值试验中试样在不同围压下应力及变形的发展,从颗粒运动角度探讨试样宏观应力应变剪胀特性演化的细观机制;细观组构与宏观应力变形的发展之间具有同步性,反映试样宏细观演化的统一性;通过对颗粒细观各向异性的统计分析,揭示颗粒间摩擦及咬合作用是维持细观力学结构相对稳定的重要因素;通过对力链网络的形态演化分析,发现试样大主应力方向与各向异性主方向一致,力链密集程度随压缩过程先上升后下降,试样孔隙度也随之先减小后增大,反映了试样宏观先减缩后剪胀的特性. | 罗滔 李刚 OOIE T CHAN A HC 傅少君 邹维列 | 2018 | 武汉大学学报(工学版)2018，51，7： | 4 |
| 12 | Moving Force Identification - Time Domain Method显示文摘 | Law S S Chan T H T Zeng Q H | 1997 | Journal of Sound and Vibration1997，201，1： | 4 |
| 13 | 多机组空调系统部分负荷下的节能策略研究显示文摘针对冷水机组大部分时间都是在部分负荷下运行的现状,提出了一种多机组空调系统并联的节能策略.运用模型仿真和试验验证手段研究节能优化运行策略对机组性能改善效果.试验结果表明:当机组由100%负荷降为50%负荷时,机组的冷凝温度由47.2℃下降到42.5℃,蒸发温度由2.2℃上升到3.5℃,COP值提高9.5%.从而表明该节能策略对多机组空调系统在部分负荷下的性能改善具有较大潜力.同时针对试验结果与仿真结果存在的差距,分析了产生的原因并提出了进一步的改进措施. | 梁彩华 张小松 徐国英 Chan K T | 2008 | 应用基础与工程科学学报2008，16，5： | 3 |
| 14 | WRN解旋酶是治疗微卫星不稳定型癌症的新靶点显示文摘由基因突变或启动子超甲基化引发的DNA错配修复(MMR)缺陷会造成核苷酸重复区(微卫星)序列超突变,即微卫星不稳定性(MSI).MSI可促进多种癌症的发生,包括结肠(15%)、胃(22%)、子宫内膜(20%~30%)和卵巢(12%),其中有45%~60%不响应免疫检查点封锁.因此,MSI型肿瘤需要新的治疗方法.研究人员猜测由MSI导致的基因组缺陷能与其他基因的失活形成合成致死关系,协同杀死癌细胞. | Chan EM Shibue T McFarland JM | 2019 | 国际老年医学杂志2019，40，6： | 3 |
| 15 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 16 | 一种模拟堆石料的二维多边形离散单元法及程序显示文摘在考虑堆石料真实颗粒形状的基础上,将每个颗粒用一个多边形离散单元表示,基于一种线性搜索算法对多边形-多边形之间的接触详情进行检索计算,引入基于势能原理的法向多边形-多边形接触模型及切向库仑摩擦模型,形成了一种多边形离散元计算方法,并开发了相应的PDEM程序。可以从颗粒尺度层面展示颗粒之间的相互作用以及每个颗粒的位移和转动,帮助进一步揭示颗粒的细观特性(形状、大小、材料特性等)对堆石料的宏观强度和变形的影响。最后采用PDEM程序对某粗粒料的二维模型试验进行了数值模拟,得到了与室内试验一致的应力变形规律,展现了其方法和程序用于研究堆石料的有效性。 | 罗滔 OOI E T CHAN A H C 傅少君 | 2017 | 岩土力学2017，38，3： | 2 |
| 17 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 18 | Moving Force Identification - A Frequency and Time Domains Approach显示文摘 | LawSS Chan T H T Zeng Q H | 1999 | Journal of Dynamic Systems Measurement and Control ASME1999，121，3： | 2 |
| 19 | Analysis of projection methods for solving linear systems with multiple right-hand sides显示文摘 | T Chan W Wang | 1997 | SIAM J Sci Comput1997，18，： | 2 |
| 20 | Weighted essentially nonoscillatory scheme显示文摘 | Liu X D Osher S Chan T | 1994 | J Comput phys1994，115，： | 2 |
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