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| 1 | Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer显示文摘AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or chemoradiotherapy.Informed consent was obtained.This study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at pre-therapy.There were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,4.Treatment after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care treatments.Adverse events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in 1.However,no severe adverse events occurred in this study.CONCLUSION:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC. | Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi | 2014 | World Journal of Gastroenterology2014，20，28： | 12 |
| 2 | Temporary pancreatic stent to prevent post endoscopic retrograde cholangiopancreatography pancreatitis: a preliminary, single-center, randomized controlled trial显示文摘 | Takayoshi Tsuchiya Takao Itoi Atsushi Sofuni Fumihide Itokawa Toshio Kurihara Kentaro Ishii Syujiro Tsuji Takashi Kawai Fuminori Moriyasu | 2007 | Journal of Hepato - Biliary - Pancreatic Surgery2007，，3： | 4 |
| 3 | Usefulness of contrast-enhanced ultrasonography in determining treatment efficacy and outcome after pancreatic cancer chemotherapy显示文摘AIM:To investigate if contrast-enhanced ultrasonography(CE-US) is useful for determining treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy by assessing changes in intratumor hemodynamics using CE-US with a contrast agent.METHODS:The subjects were 34 patients with unresectable advanced pancreatic cancer treated by chemotherapy.CE-US was assessed after every treatment(course) completion under the same conditions,and patients were divided into two groups according to the intratumor enhancement pattern:Vascular rich(R) group and vascular poor(P) group.RESULTS:After the second course of treatment,R group in intratumor hemodynamics had 18 patients,and P group had 16 patients.The reduction rates of serum CA19-9 level after chemotherapy which decreased to half or less of the baseline level were 2/15(0.1%) in P group,but 11/16(69%) in R group(P = 0.006).When the mean number of courses of chemotherapy and outcome were compared,P group had a mean number of courses of 4.9(R group,10.2) and mean survival time(MST) of 246 d(R group,402 d),showing that outcome was significantly better in R group(P=0.006).CONCLUSION:CE-US revealed that the change in intratumor blood flow correlated with both serum CA19-9 level and outcome.Patients with serum CA19-9 that decreased to less than half the baseline level,and patients with an abundant intratumor blood flow,had a significantly better outcome.Thus,CE-US is potentially useful for evaluating treatment efficacy and outcome in the early stages of pancreatic cancer chemotherapy. | Atsushi Sofuni Takao Itoi Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Fuminori Moriyasu | 2008 | World Journal of Gastroenterology2008，14，47： | 3 |
| 4 | Biliary Reconstruction in Right Lobe Living-Donor Liver Transplantation: Comparison of Different Techniques in 321 Recipients显示文摘 | Mureo Kasahara Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Sakamoto Tetsuya Kiuchi Syujiro Yazumi Toshiya Shibata Koichi Tanaka | 2006 | Annals of Surgery2006，，4： | 1 |
| 5 | Real-time virtual sonography visualization and its clinical application in biliopancreatic disease显示文摘AIM:To evaluate the usefulness of real-time virtual sonography(RVS)in biliary and pancreatic diseases.METHODS:This study included 15 patients with biliary and pancreatic diseases.RVS can be used to observe an ultrasound image in real time by merging the ultrasound image with a multiplanar reconstruction computed tomography(CT)image,using pre-scanned CT volume data.The ultrasound used was EUB-8500with a convex probe EUP-C514.The RVS images were evaluated based on 3 levels,namely,excellent,good and poor,by the displacement in position.RESULTS:By combining the objectivity of CT with free scanning using RVS,it was possible to easily interpret the relationship between lesions and the surrounding organs as well as the position of vascular structures.The resulting evaluation levels of the RVS images were12 excellent(pancreatic cancer,bile duct cancer,cholecystolithiasis and cholangiocellular carcinoma)and 3 good(pancreatic cancer and gallbladder cancer).Compared with conventional B-mode ultrasonography and CT,RVS images achieved a rate of 80%superior visualization and 20%better visualization.CONCLUSION:RVS has potential usefulness in objective visualization and diagnosis in the field of biliary and pancreatic diseases. | Atsushi Sofuni Takao Itoi Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Fuminori Moriyasu | 2013 | World Journal of Gastroenterology2013，19，42： | 1 |
| 6 | 右叶活体供肝移植术中的胆道重建:321例受者间不同术式的比较研究显示文摘目的:旨在确定右叶活体供肝移植术(Living—Donor Liver Transplantation,LDLT)后,接受胆总管端端吻合术或Roux—en—Y胆总管空肠吻合术重建胆道的患者其胆道并发症的发生率。概要背景资料:胆道并发症一直以来都是肝移植术后最严重的并发症之一。迄今未进行过任何大型系列研究比较LDLT中的这两种技术。本研究对应用的胆道重建方法利报道的并发症间的关系作了一项刚顷性评价。方法:1998年2月至2004年6月间,共有321例患者接受了柯叶LDLT。121例接受Roux—en—Y胆总管空肠吻合术,192例接受胆总管端端吻合术,8例接受Roux—en—Y和端端胆总管吻合术,均成功重建胆道。对胆管移植物和吻合数量、吻合方法、支架的应用,胆道并发症的处理都作了分析。结果:胆道并发症的总发病率为24.0%。单变量分析显示,肝动脉片发症,臣细胞病毒感染和由型不合址发生胆道并发症的重要危险闲素。Roux—en—Y和端端吻合重建术的胆漏和胆道狭窄的发病率分别为12.4%与8.3%和4.7%与26.6%。研究显示,胆总管端端吻合术中胆漏发生率较低而胆道狭窄的发生率较高;然而,74.5%的胆道狭窄都可通过内镜得到治疗。结论:作者发现胆总管端端吻合术中,胆道狭窄的发生率增高。端端吻合的胆道重建术由于保持较好的胆肠生理连续性,所以胆漏发生率更低,加之内镜治疗的简便易行,它成为石叶LDLT中较为适宜的一种手术方法。 | Kasahara, Mureo Egawa, Hiroto Takada, Yasutsugu Oike , Fumitaka Sakamoto, Seisuke Kiuchi, Tetsuya Yazumi, Syujiro Shibata, Toshiya Tanaka, Koichi | 2007 | 医学信息(手术学分册)2007，20，8： | 0 |
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