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| 1 | Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids显示文摘Hepatocellular carcinoma(HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor. Therefore, to provide optimal treatment for each patient with HCC, more precise and effective biomarkers are urgently needed which could facilitate a more detailed individualized decision-making during HCC treatment, including the following; risk assessment, early cancer detection, prediction of treatment or prognostic outcome. In the blood of cancer patients, accumulating evidence about circulating tumor cells and cell-free nucleic acids has suggested their potent clinical utilities as novel biomarker. This concept, so-called 'liquid biopsy' is widely known as an alternative approach to cancer tissue biopsy. This method might facilitate a more sensitive diagnosis and better decision-making by obtaining genetic and epigenetic aberrations that are closely associated with cancer initiation and progression. In this article, we review recent developments based on the available literature on both circulating tumor cells and cell-free nucleic acids in cancer patients, especially focusing on Hepatocellular carcinoma. | wataru okajima shuhei komatsu daisuke ichikawa mahito miyamae takuma ohashi taisuke imamura jun kiuchi keiji nishibeppu tomohiro arita hirotaka konishi atsushi shiozaki ryo morimura hisashi ikoma kazuma okamoto eigo otsuji | 2017 | World Journal of Gastroenterology2017，23，31： | 22 |
| 2 | Changes in portal venous pressure in the early phase after living donor liver transplantation: pathogenesis and clinical implications1,2显示文摘 | Takashi Ito Tetsuya Kiuchi Hidekazu Yamamoto Fumitaka Oike Yasuhiro Ogura Yasuhiro Fujimoto Kazuhiro Hirohashi and Koichi Tanaka | 2003 | Transplantation2003，，8： | 3 |
| 3 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 4 | Intraperitoneal Hyperthermic Perfusion Combined with Surgery Effective for Gastric Cancer Patients with Peritoneal Seeding显示文摘 | SHIGERU FUJIMOTO RAM DHOJ SHRESTHA MASASHI KOKUBUN MASAYASU OHTA MAKOTO TAKAHASHI KOKURIKI KOBAYASHI SOHZABURO KIUCHI KATSUJI OKUI TAKEYOSHI MIYOSHI NOBORU ARIMIZU HIROYOSHI TAKAMIZAWA | 1988 | Annals of Surgery1988，，1： | 2 |
| 5 | Changes in fecal microflora induced by incubation of mice with Bacillus subtilis (natto) spores are dependent upon dietary components显示文摘 | Hosoi T Ametani A Kiuchi K | 1999 | Canadian journal of microbiology1999，45，： | 1 |
| 6 | Mushy/semi-solid metal forming technology-present and future显示文摘 | Kiuchi M Kopp R | 2002 | Annals of the CIRP2002，51，2： | 1 |
| 7 | Living-related liver transplantation for Alagille syndrome 显示文摘 | Kasahara M Kiuchi T Inomata Y | 2003 | Transplantation2003，75，12： | 1 |
| 8 | Computer aided design of rolls for reshaping processes from round pipe to 'Channel-type' pipes显示文摘 | Kiuchi M | 2001 | Journal of Materials Processing Technology2001，111，： | 1 |
| 9 | Theory and Measurement of resiesdual strs in sheets,bars and tubes显示文摘 | | 2000 | Journal of the JCBRA2000，39，1： | 1 |
| 10 | Surgery –related morbidity in living donors of right-lobe liver graft:lessons from the first 200 cases显示文摘 | Ito T Kiuchi T Egawa H | 2003 | Transplantation2003，76，： | 1 |
| 11 | Living- related donor liver transplantation: Status Quo in Kyoto, Japan显示文摘 | Kiuchi T Tanaka T | 1998 | Transplant Proc1998，30，： | 1 |
| 12 | IMPACT OF GRAFT SIZE MISMATCHING ON GRAFT PROGNOSIS IN LIVER TRANSPLANTATION FROM LIVING DONORS1,2显示文摘 | Tetsuya Kiuchi Mureo Kasahara Kenji Uryuhara Yukihiro Inomata Shinji Uemoto Katsuhiro Asonuma Hiroto Egawa Shiro Fujita Michihiro Hayashi Koichi Tanaka | 1999 | Transplantation1999，，2： | 1 |
| 13 | Nematocidal activity of turmeric:synergistic action of curcuminoids显示文摘 | Kiuchi F Goto Y Suqimoto N | 1993 | Chem Pharm Bull1993，41，9： | 1 |
| 14 | Identification of the right ventrieular pacing site for cardiac resynchronization therapy (CRT) guided by electroanatomieal mapping (CARTO) 显示文摘 | KIUCHI K YOSHIDA A FUKUZAWA K | 2007 | Cite J2007，71，： | 1 |
| 15 | Effects of the patient false lumen on the long-term outcome of type B acute aortic dissection 显示文摘 | Akutsu K Nejima J Kiuchi K | 2004 | Eur J Cardiothorac Surg2004，26，2： | 1 |
| 16 | Anatomical variations and surgical strategies in right lobe living donor liver transplantation:lessons from 120 cases显示文摘 | Nakamura T Tanaka K Kiuchi T | 2002 | Transplantation2002，73，12： | 1 |
| 17 | Potential role of leptin and insulin resistance by the glucose clamp technique in coronary artery disease 显示文摘 | Isoda M Kiuchi K Nejima J | 2002 | J Cardial2002，40，2： | 1 |
| 18 | The relationship between the response to external light stimulation and behavioral states in the human fetus:how it differs from vibroaeoustie stimulation显示文摘 | Kiuchi M Nagata N Lkeno S | 2000 | Early Hum Dev2000，58，2： | 1 |
| 19 | Anatomical variations and surgical strategies in right lobe living donor liver transplantation: lessons from 120 cases1显示文摘 | Taro Nakamura Koichi Tanaka Tetsuya Kiuchi Mureo Kasahara Fumitaka Oike Mikiko Ueda Satoshi Kaihara Hiroto Egawa Ilgin Ozden Nobuaki Kobayashi Shinji Uemoto | 2002 | Transplantation2002，，12： | 1 |
| 20 | Increased serum concentrations of advanced glycation end products:a marker of coronary artery disease activity in type 2 diabetic patients显示文摘 | Kiuchi K Nejima J Takano T | | 0，，： | 1 |
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