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| 1 | Contrast-enhanced ultrasound:The evolving applications显示文摘Contrast-enhanced ultrasound(CEUS)is a major breakthrough for ultrasound imaging in recent years.By using a microbubble contrast agent and contrast-specific imaging software,CEUS is able to depict the microand macro-circulation of the targeted organ,which in turn leads to improved performance in diagnosis.Due to the special dual blood supply system in the liver,CEUS is particularly suitable for liver imaging.It is evident that CEUS facilitates improvement for characterization of focal liver lesions(FLLs),detection of liver malignancy,guidance for interventional procedures,and evaluation of treatment response after local therapies.CEUS has been demonstrated to be equal to contrast-enhanced computed tomography or magnetic resonance imaging for the characterization of FLLs.In addition,the applicability of CEUS has expanded to non-liver structures such as gallbladder,bile duct,pancreas,kidney,spleen,breast,thyroid,and prostate.The usefulness of CEUS in these applications is confirmed by extensive literature production.Novel applications include detecting bleeding sites and hematomas in patients with abdominal trauma,guiding percutaneous injection therapy and therefore achieving the goal of using interventional ultrasonography in managing splenic trauma,assessing the activity of Crohn’s disease,and detecting suspected endoleaks after endovascular abdominal aneurysm repair.Contrast-enhanced intraoperative ultrasound(US)and intracavitary use of CEUS have been developed and clinically studied.The potential use of CEUS involves sentinel lymph node detection,drug or gene delivery,and molecular imaging.In conclusion,the advent of CEUS has greatly enhanced the usefulness of US and even changed the status of US in clinical practice.The application of CEUS in the clinic is continuously evolving and it is expected that its use will be expanded further in the future. | Hui-Xiong Xu | 2009 | World Journal of Radiology2009，1，1： | 23 |
| 2 | Contrast-enhanced harmonic endoscopic ultrasound imaging: Basic principles, present situation and future perspectives显示文摘Over the last decade, the development of stabilised microbubble contrast agents and improvements in available ultrasonic equipment, such as harmonic imaging, have enabled us to display microbubble enhancements on a greyscale with optimal contrast and spatial resolution. Recent technological advances made contrast harmonic technology available for endoscopic ultrasound(EUS) for the first time in 2008. Thus, the evaluation of microcirculation is now feasible with EUS, prompting the evolution of contrast-enhanced EUS from vascular imaging to images of the perfused tissue. Although the relevant experience is still preliminary, several reports have highlighted contrast-enhanced harmonic EUS(CHEUS) as a promising noninvasive method to visualise and characterise lesions and to differentiate benign from malignant focal lesions. Even if histology remains the gold standard, the combination of CH-EUS and EUS fine needle aspiration(EUS-FNA) can not only render EUS more accurate but may also assist physicians inmaking decisions when EUS-FNA is inconclusive,increasing the yield of EUS-FNA by guiding the puncture with simultaneous imaging of the vascularity.The development of CH-EUS has also opened up exciting possibilities in other research areas,including monitoring responses to anticancer chemotherapy or to ethanolinduced pancreatic tissue ablation,anticancer therapies based on ultrasound-triggered drug and gene delivery,and therapeutic adjuvants by contrast ultrasound-induced apoptosis.Contrast harmonic imaging is gaining popularity because of its efficacy,simplicity and noninvasive nature,and many expectations are currently resting on this technique.If its potential is confirmed in the near future,contrast harmonic imaging will become a standard practice in EUS. | María-Victoria Alvarez-Sánchez Bertrand Napoléon | 2014 | World Journal of Gastroenterology2014，20，42： | 7 |
| 3 | 超声造影及其联合血清学指标评估胰腺癌可切除性显示文摘目的 观察超声造影(CEUS)及其联合血清学指标评估胰腺癌(PCa)可切除性的价值。方法 纳入43例PCa患者,回顾性分析其临床、多层螺旋CT(MSCT)、CEUS及病理学资料。根据手术及病理结果将患者分为可切除组(n=24)及不可切除组(n=19);评价CEUS与MSCT评估PCa可切除性结果的一致性,比较组间PCa可切除性分类,即可切除、临界可切除及不可切除PCa,以及血清学指标的差异;绘制受试者工作特征曲线,观察CEUS、CEUS联合总胆红素(TBIL)及MSCT评估PCa可切除性的效能。结果 43例中,CEUS对34例(34/43,79.07%)的评估结果与MSCT相同,二者具有中等一致性(Kappa=0.668)。CEUS与MSCT评估PCa结果组间差异有统计学意义(P均<0.001)。可切除组TBIL水平低于不可切除组(P<0.05)。CEUS评估PCa可切除性的曲线下面积(AUC)与MSCT差异无统计学意义(P=0.304),而其联合TBIL评估PCa可切除性的AUC高于MSCT(P=0.042)。结论 CEUS可用于评估PCa可切除性,且其联合TBIL的评估效能优于MSCT。 | 曾兰 任思谦 李飞 李炳琦 袁蒙 刘珂 原春辉 葛辉玉 崔立刚 | 2023 | 中国医学影像技术2023，39，8： | 0 |
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