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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Predicting the Transition between Upper and Lower Bainite via a Gibbs Energy Balance Approach显示文摘The transition temperature between upper bainite and lower bainite is calculated with an extended Gibbs energy balance model, which is able to quantitatively describe the evolution of carbon supersaturation within bainitic ferrite sheaves during the entire thickening process. The nucleation rate of intra-lath cementite precipitation on a dislocation is calculated based on of the degree of carbon supersaturation.Upper bainite and lower bainite are thus distinguished by the effective nucleation density and therefore a numerical criterion can be set to define the transition. The model is applied to Fe-xC-1Mn/2Mn/1 Mo ternary alloys. Results show that the transition temperature increases with bulk carbon content at lower carbon concentration but decreases in the higher carbon region. This prediction agrees very well with the experimental observations in Mn and Mo alloyed systems. Moreover, the highest transition temperature and the carbon content at which it occurs in the Fe-xC-2Mn system are in good agreement with reported experimental data. The inverse 'V' shaped character of the carbon concentration–transition temperature curve indicates two opposite physical mechanisms operating at the same time. An analysis is carried out to provide an explanation. | Zenan Yang Wei Xu Zhigang Yang Chi Zhang Hao Chen Sybrand van der Zwaag | 2017 | Journal of Materials Science & Technology2017，33，12： | 2 |
| 3 | Charting the ‘composition–strength’ space for novel austenitic,martensitic and ferritic creep resistant steels显示文摘We report results of a large computational 'alloy by design' study, in which the ‘chemical composition–mechanical strength' space is explored for austenitic, ferritic and martensitic creep resistant steels. The approach used allows simultaneously optimization of alloy composition and processing parameters based on the integration of thermodynamic, thermo-kinetics and a genetic algorithm optimization route. The nature of the optimisation depends on both the intended matrix(ferritic, martensitic or austenitic) and the desired precipitation family. The models are validated by analysing reported strengths of existing steels. All newly designed alloys are predicted to outperform existing high end reference grades. | Qi Lu Sybrand van der Zwaag Wei Xu | 2017 | Journal of Materials Science & Technology2017，33，12： | 2 |
| 4 | Microstructure and dislocation structure evolution during creep life of Ni-based single crystal superalloys显示文摘The high performance of Ni single crystal superalloys during high temperature low stress creep service,is intrinsically determined by the combined effects of microstructural evolution and the dislocation behaviour.In the field of the evolution of dislocation network,two main recovery mechanism based on dislocation migration dominate the process.One is superdislocations shearing intoγ’rafts through a two-superpartials-assisted approach.Another is the compact dislocations migrating alongγ/γ’interface.These two mechanisms are similarly climb-rate-controlled process.In this work,a model for the minimum creep rate based on thermodynamic and kinetic calculations and using an existing detailed dislocation dynamics model has been built by taking the dislocation migration behaviours as well as the rafted microstructure into consideration,which can well reproduce the([100]tensile)creep properties of existing Ni superalloy grades,without the need to make the dislocation parameter values composition dependent. | Hao Yu Wei Xu Sybrand van der Zwaag | 2020 | Journal of Materials Science & Technology2020，42，10： | 2 |
| 5 | A Review of Self-healing Metals: Fundamentals, Design Principles and Performance显示文摘Self-healing metals possess the capability to autonomously repair structural damage during service. While self-healing concepts remain challenging to be realized in metals and metallic systems due to the small atomic volume of the mobile atoms, the slow diffusion unless at high temperatures and the strong isotropic metallic bonds, the scientific interest has increased sharply and promising progress is obtained. This article provides a comprehensive and updated review on the developments and limitations associated with the various modes of potentially healable damage induced in metals and alloys, i.e., stressinduced damage, irradiation-induced damage in bulk materials and contact damage in corrosion protective coatings. The spontaneous intrinsic healing mechanisms not requiring external assistance other than the material operating at the right temperature and an assisted healing mechanism with external intervention are reviewed. Promising strategies to achieve self-healing in metals are identified. Finally, we give some prospects for future research directions in self-healing metals. | Shasha Zhang Niels van Dijk Sybrand van der Zwaag | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，9： | 1 |
| 6 | Principle and perspectives of hydrogen production through biocatalyzed electrolysis显示文摘 | René A. Rozendal Hubertus V.M. Hamelers Gerrit J.W. Euverink Sybrand J. Metz Cees J.N. Buisman | 2006 | International Journal of Hydrogen Energy2006，，12： | 1 |
| 7 | Ecology on the edge: landscape and ecology between town and country显示文摘 | Sybrand P Tjiallingii | 2000 | Landscape and Urban Planning2000，，48： | 1 |
| 8 | Compositional variations of olivine from the Jinchuan Ni–Cu sulfide deposit, western China: implications for ore genesis显示文摘 | Chusi Li Zhanghua Xu Sybrand A. Waal Edward M. Ripley Wolfgang D. Maier | 2004 | Mineralium Deposita2004，，2： | 1 |
| 9 | Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine显示文摘 | Nanne K.H. de Boer Carin M.J. van Nieuwkerk M. Nieves Aparicio Pages Sybrand Y. de Boer Luc J.J. Derijks Chris J.J. Mulder | 2005 | European Journal of Gastroenterology & Hepatology2005，，4： | 1 |
| 10 | Compositional variations of olivine from the Jinchuan Ni–Cu sulfide deposit, western China: implications for ore genesis显示文摘 | Chusi Li Zhanghua Xu Sybrand A. Waal Edward M. Ripley Wolfgang D. Maier | 2004 | Mineralium Deposita2004，，2： | 1 |
| 11 | The influence of carbon diffusion on the character of the γ-α phase transformation in steel显示文摘 | Yvonne van Leeuwen Jilt Sietsma and Sybrand van der Zwaag | 2003 | ISIJ Intemational2003，43，5： | 1 |
| 12 | Compositional variations of olivine from the Jinchuan Ni-Cu sulfide deposit, Western China: Implications for ore genesis显示文摘 | Li C S Xu Z H Sybrand A W | 2004 | Mincralium Deposita2004，39，2： | 1 |
| 13 | A Meta llurgical Interpretation of the Static Recrystallization Kinetics of an Intercritically Deformed C Mn Steel 显示文摘 | Luo Haiwen Jilt Sietssma Sybrand Van Der Zwaag | 2004 | Metallurgical and Ransactions2004，356，： | 1 |
| 14 | Effects of carbon concentration and cooling rate on continuous cooling transformations predicted by artificial neural network 显示文摘 | J J Wang Pieter J van der Wolk Sybrand van der Zwaag | 1999 | ISIJ International1999，39，10： | 1 |
| 15 | The effect of geometrical assumptions in modeling solid-state transformation kinetics显示文摘 | Yvonne Leeuwen Simone Vooijs Jilt Sietsma Sybrand Zwaag | 1998 | Metallurgical and Materials Transactions A1998，，12： | 1 |
| 16 | Prediction of the continuous cooling transformation diagram of some selected steels using artificial neural networks 显示文摘 | Vermeulen W Sybrand van der Zwaag Morris P | 1997 | Steel Research1997，68，2： | 1 |
| 17 | Monitoring the precipitation reactions in a cold rolled Al-Zn-Mg-Cu alloy using thermoelectric power and resistivity measurements 显示文摘 | Bruce D Sybrand Z | 2000 | Mater Sci Forum2000，，： | 1 |
| 18 | Stabilization mechanisms of retained austenite in transformation-induced plasticity steel显示文摘 | Jiajun Wang Sybrand Zwaag | 2001 | Metallurgical and Materials Transactions A2001，，6： | 1 |
| 19 | A conceptual study into the potential of Mn+1 AXn phase ceramics for self-healing of crack damage显示文摘 | Ann-Sophie Farle Cees Kwakernaak Sybrand van der Zwaag | 2015 | J Eur Ceram SOc2015，35，： | 1 |
| 20 | Stabilization mechanisms of retained austenite in transformation-induced plasticity steel显示文摘 | Jiajun Wang Sybrand Zwaag | 2001 | Metallurgical and Materials Transactions A2001，，6： | 1 |
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