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| 1 | Phenotypic heterogeneity of mutations in androgen receptor gene显示文摘雄激素受体(AR ) 基因广泛地处于多样的临床的条件被学习了。除了点变化, trinucleotide 重复(CAG 和 GGN ) 长度多型性在遗传学者之中是兴趣和争吵的一个另外的题目。在三位字节重复的 Thepolymorphic 变化与很多混乱被联系了,但是同时矛盾的调查结果也被报导了。进一步,在不同人口的一样的混乱上的研究产生了不同结果。因此,联合了分析或出版研究的评论具有许多价值处于各种各样的临床的条件在基因在变化的意义上提取信息。AR 遗传广泛地被考察了,但是直到现在,评论文章集中于象 androgeninsensitivity 那样的单个临床的范畴,男不孕,前列腺癌症等等。我们作了第一个努力最考察 AR 遗传的方面。在各种各样的混乱的雄激素和在 AR 基因的多态的变化的影响是这评论的主要焦点。另外,在各种各样的研究观察的关联被讨论了根据在为在雄激素的行动以后的 AR 基因变化的效果可得到的 vitro 证据。 | Singh Rajender Lalji Singh Kumarasamy Thangaraj | 2007 | Asian Journal of Andrology2007，9，2： | 24 |
| 2 | Coinfection of hepatitis B and hepatitis C virus in HIV-infectedpatients in south India显示文摘AIM: To screen for the co-infection of hepatitis B (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected patients in southern India. METHODS: Five hundred consecutive HIV infected patients were screened for Hepatitis B Virus (HBsAg and HBV-DNA) and Hepatitis C virus (anti-HCV and HCV-RNA) using commercially available ELISA kits; HBsAg, HBeAg/ anti-HBe (Biorad laboratories, USA) and anti-HCV (Murex Diagnostics, UK). The HBV-DNA PCR was performed to detect the surface antigen region (pre S-S). HCV-RNA was detected by RT-PCR for the detection of the constant 5' putative non-coding region of HCV. RESULTS: HBV co-infection was detected in 45/500 (9%) patients and HCV co-infection in 11/500 (2.2%) subjects. Among the 45 co-infected patients only 40 patients could be studied, where the detection rates of HBe was 55% (22/40), antiHBe was 45% (18/40) and HBV-DNA was 56% (23/40). Among 11 HCV co-infected subjects, 6 (54.5%) were anti-HCV and HCV RNA positive, while 3 (27.2%) were positive for anti-HCV alone and 2 (18%) were positive for HCV RNA alone. CONCLUSION: Since the principal routes for HIV transmission are similar to that followed by the hepatotropic viruses, as a consequence, infections with HBV and HCV are expected in HIV infected patients. Therefore, it would be advisable to screen for these viruses in all the HIV infected individuals and their sexual partners at the earliest. | Shanmugam Saravanan Vijayakumar Velu Nagalingeswaran Kumarasamy Subhadra Nandakumar Kailapuri Gangatharan Murugavel Pachamuthu Balakrishnan Solomon Suniti Sadras Panchatcharam Thyagarajan | 2007 | World Journal of Gastroenterology2007，13，37： | 6 |
| 3 | Androgen insensitivity syndrome: do trinucleotide repeats in androgen receptor gene have any role?显示文摘瞄准:为了调查 CAG 和 GGN 的角色,作为在敏感症候群(AIS ) 影响雄激素的基因背景重复显型。方法:我们分析了一些 -CAG 和 GGN 在 69 个 AIS 案例中重复的雄激素受体(AR ) ,与 136 个无关的正常男个人一起。重复的长度用扩大由突变而产生之遗传的 genotyping 跟随了决定等位基因长度的聚合酶链反应(PCR ) 被分析。结果:我们揭示的学习更突然显著地在病人意味着一些 CAG 重复(平均数 18.25 重复,范围 14-26 重复) 与控制相比(平均数 22.57 重复,范围 12-39 重复)( 二尾巴的 P <
0.0001 ) 。然而, GGN 重复没在病人(平均数 21.48 重复) 和控制(平均数 21.21 重复) 之间显著地不同(二尾巴的 P = 0.474 ) 。在病人的组之中, CAG 的吝啬的数字在敏感情况(平均数 15.83 重复) 中在部分雄激素重复显著地不到在里面在敏感情况(平均数 19.46 重复) 中的完全的雄激素(二尾巴的 P <
0.0001 ) 。结论:调查结果建议在 AR 基因的重复的更短的长度可能充当低外显率在在敏感改变雄激素的表明的基因背景。 | Singh Rajender Nalini J. Gupta Baidyanath Chakravarty Lalji Singh Kumarasamy Thangaraj | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 4 | Emergence of a new antibiotic resistance mechanism in India,Pakistan,and the UK:a molecular,biological,and epidemiological study显示文摘 | WOODFORD N KUMARASAMY K K TOLEMAN M A | | Lancet Infectious Diseases0，，： | 2 |
| 5 | Emergence of a new antibiotic resistance m echanism in India,Pakistan,and the UK:a molecular,biological,andepidemiological study显示文摘 | Kumarasamy KK Toleman MA Walsh TR at al | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 6 | Emergence of a new antibiotic resistance mechanism in India,Pakistan,and the UK:a molecular,biological,and epidemiological study显示文摘 | Kumarasamy KK Toleman MA Walsh TR | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 7 | Prevalence and incidence of swxually transmitted infections among South Indians at increased risk of HIV infection显示文摘 | Kumarasamy N Balakrishnan P Venkatesh KK | 2008 | AIDS Patient Care STDS2008，22，8： | 1 |
| 8 | Emergence of a new antibiotic resistance mechanism in India,Pakistan,and the UK:a molecular,biological,and epidemiological study显示文摘 | KUMARASAMY K K | 2010 | Lancet Infect2010，10，9： | 1 |
| 9 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR | 2010 | Lancet infect dis2010，10，9： | 1 |
| 10 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman M Walsh TR | 2010 | Lancet Infect Dis2010，10，： | 1 |
| 11 | Emergence of a new antibiotic resistance mechanism in India,Pakistan,and the UK:a molecular,biological,and epidemiological study显示文摘 | Kumarasamy KK Toleman MA Walsh TR | | 0，，09： | 1 |
| 12 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 13 | Emer- gence of a new antibiotic resistance mechanism in India, Pakistan, and the UK:a molecular, biological, and epi- demiological study 显示文摘 | Kumarasamy KKM Toleman MA Walsh TR | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 14 | Emergence tff a new antibiotic resistance mechanism in India,Pakistan aml the UK: a molecular ,biological, and cpidemiological study 显示文摘 | Kumarasamy KK Tolcman MA Walsh TR et :d | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 15 | A regioselective multicomponent protocol for the synthesis of novel bioactive 4-hydroxyquinolin-2(1H)-one grafted monospiropyrrolidine and thiapyrro-lizidine hybrids显示文摘 | Mathan S Chokkalingam U Kumarasamy C | 2014 | Molecular diversity2014，18，： | 1 |
| 16 | Chikungunya virus of Central/East African genotype detected in Malaysia 显示文摘 | Soon YY Junaidi I Kumarasamy V | 2007 | Med J Malaysia2007，62，3： | 1 |
| 17 | Risk factors for HIV transmission among heterosexual discordant couples in south India 显示文摘 | Kumarasamy N Venkatesh KK Srikrishnan AK | 2010 | HIV Med2010，11，3： | 1 |
| 18 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 19 | Evalu-ation of a commercial dengue NS1 antigen captureELISA for laboratory diagnosis of acute dengue virusinfection显示文摘 | Kumarasamy V Wahab A H Chua S K | 2007 | J Virol Methods2007，140，12： | 1 |
| 20 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study显示文摘 | Kumarasamy KK Toleman MA Walsh TR | 2010 | Lancet Infect Dis2010，10，9： | 1 |
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