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| 1 | Status of precision medicine approaches to traumatic brain injury显示文摘Traumatic brain injury(TBI)is a serious condition in which trauma to the head causes damage to the brain,leading to a disruption in brain function.This is a significant health issue worldwide,with around 69 million people suffering from TBI each year.Immediately following the trauma,damage occurs in the acute phase of injury that leads to the primary outcomes of the TBI.In the hours-to-days that follow,secondary damage can also occur,leading to chronic outcomes.TBIs can range in severity from mild to severe,and can be complicated by the fact that some individuals sustain multiple TBIs,a risk factor for worse long-term outcomes.Although our knowledge about the pathophysiology of TBI has increased in recent years,unfortunately this has not been translated into effective clinical therapies.The U.S.Food and Drug Administration has yet to approve any drugs for the treatment of TBI;current clinical treatment guidelines merely offer supportive care.Outcomes between individuals greatly vary,which makes the treatment for TBI so challenging.A blow of similar force can have only mild,primary outcomes in one individual and yet cause severe,chronic outcomes in another.One of the reasons that have been proposed for this differential response to TBI is the underlying genetic differences across the population.Due to this,many researchers have begun to investigate the possibility of using precision medicine techniques to address TBI treatment.In this review,we will discuss the research detailing the identification of genetic risk factors for worse outcomes after TBI,and the work investigating personalized treatments for these higher-risk individuals.We highlight the need for further research into the identification of higher-risk individuals and the development of personalized therapies for TBI. | Sahithi Reddi Smita Thakker-Varia Janet Alder Anna O.Giarratana | 2022 | Neural Regeneration Research2022，17，10： | 3 |
| 2 | Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering显示文摘 | Swetha M Sahithi K Moorthi A | 2010 | Int J Biol Macromol2010，1，： | 1 |
| 3 | Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering显示文摘 | Maddela Swetha Kolli Sahithi Ambigapathi Moorthi Narasimhan Srinivasan Kumarasamy Ramasamy Nagarajan Selvamurugan | 2010 | International Journal of Biological Macromolecules2010，，1： | 1 |
| 4 | Biocomposites containingnatural polymers and hydroxyapatite for bonetissueengineering显示文摘 | Swetha M Sahithi K Moorthi A | 2010 | Int J Biol Macromol2010，47，1： | 1 |
| 5 | Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering 显示文摘 | Swetha M Sahithi K Moorthi A | 2010 | Int J Biol Maeromol2010，47，1： | 1 |
| 6 | Biocomposites containing natural poymers and hydroxyapatite for bone tissue engineering 显示文摘 | SWETHA M SAHITHI K MOORTHI A | 2010 | Intemational Journal of Biological Macromolecules2010，47，1： | 1 |
| 7 | Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering 显示文摘 | Swetha M Sahithi K Moorthi A | 2010 | Int J BiolMacromol2010，47，1： | 1 |
| 8 | Intravesical botulinum toxin A injections in the treatment of painful bladder syndrome/interstitial cystitis: a systematic review显示文摘 | Sahithi Tirumuru Deyaa Al-Kurdi Pallavi Latthe | 2010 | International Urogynecology Journal2010，，10： | 1 |
| 9 | Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering 显示文摘 | Swetha M Sahithi K Moorthi A | 2010 | Int J Biol Macromol2010，47，1： | 1 |
| 10 | Biocomposites containingnatural polymers and hydroxyapatite for bone tissue engineering 显示文摘 | Swetha M Sahithi K Moorthi A | 2010 | Int J Biol Maeromol2010，47，： | 1 |
| 11 | Biocompositescontaining natural polymers and hydroxyapatite for bone tis- sueengineering显示文摘 | SWETHA M SAHITHI K MOORTHi A | 2010 | International Journal of Biological Macromolecu- les2010，47，1： | 1 |
| 12 | Synthesis, characterization, and antimicrobial activity of nano-hydroxyapatite-zinc for bone tissue engineering applications显示文摘 | Swetha M Sahithi K Moorthi A et aI | 2012 | J Nanosci Nanotechnol2012，12，1： | 1 |
| 13 | Biocomposites comaining natural polymers and hydroxyapatite for Lone tissue engineering显示文摘 | Swetha M Sahithi K Moorthi A | 2010 | lnlernational Journal of Biological Macromoleeules2010，47，1： | 1 |
| 14 | Ionospheric time delay corrections based on the extended single layer model over low latitude region显示文摘Ionospheric delay error is considered to be one of the most prominent factors impacting the Global Navigation Satellite Systems(GNSS) positioning and navigation accuracies. Due to dispersive nature and anisotropic of the ionosphere above certain regions, the positioning accuracy is seriously affected when using a precision-limited model. In this paper, an attempt has been taken to estimate ionosphere-delays based on Planar Fit(PF) and Spherical Harmonic Function(SHF) models by applying the commonly used single layer Model(SLM) and an extended single layer model(ESLM) which has been explored sparsely over the region. The results show that ESLM of PF and SHF techniques performed better in estimating ionospheric delay compared to the existing SLM model. Although the performance of the ESLM approach is almost comparable to the SLM results during the quiet ionospheric conditions, the ESLM-PF and ESLMSHF models led to respective improvements of 4.66% and 7.14% over the classically used SLM model under the disturbed ionospheric conditions. In view of the uneven variability of equatorial/low latitude ionosphere above the Indian subcontinental region, the suitability of ESLM-PF and ESLM-SHF models has been emphasized and suggested for assessing its completeness and reliableness across other parts of the globe. The output of this work may be useful for high precession GNSS positioning through mitigating the ionospheric delays under quiet as well as varied ionospheric conditions across the low/equatorial latitude regions. | Sahithi Karanam D.Venkata Ratnam J.R.K.Kumar Dabbakuti | 2019 | Geodesy and Geodynamics2019，10，3： | 0 |
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