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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Parental cigarette smoking and the risk of spontaneous abortion显示文摘 | Windham GC Swan SH Fenster L | 1992 | Am J Epidemiol1992，135，： | 2 |
| 3 | Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma 显示文摘 | Fregonese L Swan F J van Schadewijk A | 2005 | J Allergy Clin Immunol2005，115，6： | 1 |
| 4 | Consumer Perceptions of Interpersonal Equity and Satisfaction in Transactions : A Field Survey Approach 显示文摘 | OLIVER R L SWAN J E | 1989 | Jour- nal of Marketing1989，，4： | 1 |
| 5 | Encouraging 'frienAly'complaints behavior in industrial markets-reventing the loss of customers and reputation显示文摘 | Scott W Hansen John E Swan Thomas L Powers | 1996 | Industrial Marketing Management1996，，25： | 1 |
| 6 | Self-reported abstinence effects in the first month after smoking cessation显示文摘 | WARD M M SWAN G E JACK L M | 2001 | Addict Behav2001，26，3： | 1 |
| 7 | The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996 显示文摘 | Swan S H Elkin E P Fenster L | 2000 | Environ Health PersI)ect2000，108，10： | 1 |
| 8 | Modeling of End-use Energy Consumption in the Residential Sector: a Review of Modeling Teehniques显示文摘 | Swan L V I Ugursal | 2009 | Re- newable and Sustainable Energy Reviews2009，13，8： | 1 |
| 9 | The question of declining sperm density revisited:an analysis of 101 studies published 1934-1996显示文摘 | Swan SH Elkin EP Fenster L | 2000 | Environ Health Perspect2000，108，10： | 1 |
| 10 | The question of declining sperm density revisited:An analysis of 101 studies published 1934-1996显示文摘 | Swan SH Elkin EP Fenster L | | 0，，10： | 1 |
| 11 | Consumer perceptions of interpersonal equity and satisfaction in transactions : A field survey ap- proach显示文摘 | OLIVER R L SWAN J E | 1989 | Journal of Marketing1989，，8： | 1 |
| 12 | Surface soil moisture and stubble management practice effects on the progress of infection of wheat by Fusarium pseudograminearum 显示文摘 | Swan L J Backhouse D Burgess L W | 2000 | Australian Journal of Experimental Agriculture2000，40，： | 1 |
| 13 | Social physique anxiety in postmenopausal women显示文摘 | Ransdell L B Wells C L Manore M M Swan P D & Corbin C | 1998 | Journal of Women & Aging1998，10，： | 1 |
| 14 | Equity and disconfirmationperceptions as influences on merchant and productsatisfaction 显示文摘 | Oliver R L Swan J E | 1989 | Joural of Consumer Research1989，16，12： | 1 |
| 15 | Modeling of End-use Energy Con- sumption in the Residential Sector: A Review of Modeling Techniques 显示文摘 | Swan L G Ugursal V I | 2009 | Renewable and Sustainable Energy Reviews2009，13，8： | 1 |
| 16 | Challenges of online teacher professional development communities显示文摘 | Zygouris-Coe V l Swan B | 2009 | Online Learning Communities and Teacher Professional Development: Methods for Improved Education Delivery: Methods for Improved Education Delivery2009，，： | 1 |
| 17 | A randomised controlled trial of intravinousimmunoglobulin in IgM paraprotein associated demyelinating neuropathy显示文摘 | Roveri L Swan A | 2002 | J Neurol2002，249，10： | 1 |
| 18 | Consumer perceptions of interpersonal equity and satisfaction in transactions: a field survey approach 显示文摘 | OLIVER R L SWAN J E | 1989 | Jour- nal of Marketing1989，53，2： | 1 |
| 19 | Ambulatory electrocardiographic evidence of transmuraldispersion of repolarization in patients with long-QT syndrometype 1 and 2显示文摘 | VIITASALO M OIKARINEN L SWAN H | 2002 | Circulation2002，106，19： | 1 |
| 20 | Consumer perceptions of interpersonal equity and satisfaction in transactions : A field survey ap- proach显示文摘 | OLIVER R L SWAN J E | 1989 | J Mark1989，53，2： | 1 |
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