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| 1 | Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs显示文摘AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious dogs.METHODS:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist administration.The force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and colon.Test materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive state.The effects of these receptor antagonists on normal gastrointestinal motor activity were analyzed.RESULTS:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal ileum.The 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor activity.In the proximal colon,the inhibitory effect was dose dependent.Dose dependency,however,was not observed in the distal colon.The 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.CONCLUSION:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity.The5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. | Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii Tetsuro Ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Effect of grain size and texture on pseudoelasticity in Cu A1-Mn-based shape memory wire 显示文摘 | SUTOU Y OMORI T YAMAUCHI K ONO N KA1NUMA R ISHIDA K | 2005 | Acta Mater2005，53，41： | 1 |
| 3 | Effects of porosity on leaching of Ca from hardened ordinary Portland cement paste显示文摘 | Kazuko Haga Shunkichi Sutou Michihiko Hironaga Satoru Tanaka Shinya Nagasaki | 2004 | Cement and Concrete Research2004，，9： | 1 |
| 4 | Magnetic and martensitic phase transformations in a Ni54Ga27Fe19 alloy 显示文摘 | OIKAWA K OTA T SUTOU Y | 2002 | Materials Transactions2002，43，： | 1 |
| 5 | Difference between ip and oral gav age application in the micronucleus test显示文摘 | Sutou S Shimada H | 1989 | Mutat Res1989，223，： | 1 |
| 6 | Phase equilibria and phase transition of the Ni-Fe-Ga Ferromagnetic shape memory alloy system显示文摘 | Oikawa K Omori T Sutou T | 2007 | The Minerals Metals&Materials Society and ASM International2007，38，： | 1 |
| 7 | Characteristics of Cu-Al- Mn-based shape memory alloys and their applications 显示文摘 | Sutou Y Omori T Wang J J | 2004 | Materials Science and Engineering2004，378，： | 1 |
| 8 | Magnetic transformation of Ni2AlMn heusler-type shape memory alloys显示文摘 | F. Gejima Y. Sutou R. Kainuma K. Ishida | 1999 | Metallurgical and Materials Transactions A1999，，10： | 1 |
| 9 | Relationship between deformation twinning and surface step formation in AZ31 magnesium alloys显示文摘 | ANDO D KOIKE J SUTOU Y | 2010 | Acta Mater2010，58，： | 1 |
| 10 | Usage of putative chicken U6 promoters for vector-based RNA interference 显示文摘 | Kudo T Sutou S | 2005 | J Reprod Dev2005，51，3： | 1 |
| 11 | Magnetic and martensitic transformations of NiMnX(X=In,Sn,Sb) ferromagnetic shape memory alloys显示文摘 | SUTOU Y LMANO Y KOEDA N OMOR1 T KAINUM R ISHIDA K OIKAWA K | 2004 | Applied Physics Letters2004，85，19： | 1 |
| 12 | Effect of Co addition on the ordering and martensitic transformations in Cu-Al-Mn shape memory alloys显示文摘 | Sutou Y Kainuma R Ishida K | 2000 | Materials Science Forum2000，，327328： | 1 |
| 13 | Molecular cloning of chicken FTZ-F1-related orphan receptors显示文摘 | Kudo T Sutou S | 1997 | Gene1997，197，12： | 1 |
| 14 | Magnetic and martensitic transformations of NiMnX(X=In, Sn, Sb) ferromagnetic shape memory alloys显示文摘 | Sutou Y Imano Y Koeda N | 2004 | Appl Phys Lett2004，85，19： | 1 |
| 15 | Magnetic and martensitic transformations of Ni-Mn-X (X=In, Sn, Sb) ferromagnetic shape memory alloys显示文摘 | SUTOU Y IMANO Y KOEDA N OMORI T KAINUMA R ISHIDA K OIKAWA K | 2004 | Applied Physics Letter2004，85，19： | 1 |
| 16 | Effect of magnetic field on martensitic transition of Ni46Mn41In13显示文摘 | OIKAWA K ITO W IMANO Y SUTOU Y KAINUMA R ISHIDA K OKAMOTO S KITAKAMI O KANOMATA T | 2006 | Applied Physics Letter2006，88，12： | 1 |
| 17 | Magnetic transformation of Ni2AIMn Heusler-type shape memory alloys 显示文摘 | GEJIMA F SUTOU Y KAINUMA R ISHIDA K | 1999 | Metallurgical and Materials Transactions A1999，30，10： | 1 |
| 18 | Magnetic and martensitic transformations of NiMnX(X=In, Sn, Sb) ferromagnetic shape memory alloys 显示文摘 | SUTOU Y IMANO Y KOEDA N OMORI T KAINUMA R ISHIDA K OIKAWA K | 2004 | Applied Physics Letters2004，85，19： | 1 |
| 19 | Magnetic-field-induced shape recovery by reverse phase transformation显示文摘 | KAINUMA R IMANO Y ITO W SUTOU Y MORITO H OKAMOTO S KITAKAMI O OIKAWA K FUJITA A KANOMOTA T ISHIDA K | 2006 | Nature2006，439，： | 1 |
| 20 | Genomic sequence analysis of the bovine male-enhanced antigen-1 ( Mea-1 ) and differential localization of its transcripts and products during spermatogenesis显示文摘 | Masaaki Kondo Sachiko Terouchi Norie Tsukasa Seiji Sato Norio Lshlda Shizuyo Sutou | 1996 | Mitochondrial DNA1996，，2： | 1 |
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