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| 1 | Molecular aspects of intestinal calcium absorption显示文摘Intestinal Ca2+ absorption is a crucial physiological process for maintaining bone mineralization and Ca2+ homeostasis. It occurs through the transcellular and paracellular pathways. The first route comprises 3steps: the entrance of Ca2+ across the brush border membranes(BBM) of enterocytes through epithelial Ca2+ channels TRPV6, TRPV5, and Cav1.3; Ca2+ movement from the BBM to the basolateral membranes by binding proteins with high Ca2+ affinity(such as CB9k); and Ca2+ extrusion into the blood. Plasma membrane Ca2+ ATPase(PMCA1b) and sodium calcium exchanger(NCX1) are mainly involved in the exit of Ca2+ from enterocytes. A novel molecule, the 4.1R protein, seems to be a partner of PMCA1 b, since both molecules colocalize and interact. The paracellular pathway consists of Ca2+ transport through transmembrane proteins of tight junction structures, such as claudins 2, 12, and 15. There is evidence of crosstalk between the transcellular and paracellular pathways in intestinal Ca2+ transport. When intestinal oxidative stress is triggered, there is a decrease in the expression of several molecules of both pathways that inhibit intestinal Ca2+ absorption. Normalization of redox status in the intestine with drugs such as quercetin, ursodeoxycholic acid, or melatonin return intestinal Ca2+ transport to control values. Calcitriol [1,25(OH)2D3] is the major controlling hormone of intestinal Ca2+ transport. It increases the gene and protein expression of most of the molecules involved in both pathways. PTH, thyroid hormones, estrogens, p ro l a c t i n, g ro w t h h o r m o n e, a n d g l u c o c o r t i c o i d s apparently also regulate Ca2+ transport by direct action, indirect mechanism mediated by the increase of renal 1,25(OH)2D3 production, or both. Different physiological conditions, such as growth, pregnancy, lactation, and aging, adjust intestinal Ca2+ absorption according to Ca2+ demands. Better knowledge of the molecular details of intestinal Ca2+ absorption could lead to the development of nutritional and medical strategies for optimizing the efficiency of intestinal Ca2+ absorption and preventing osteoporosis and other pathologies related to Ca2+ metabolism. | Gabriela Diaz de Barboza Solange Guizzardi Nori Tolosa de Talamoni | 2015 | World Journal of Gastroenterology2015，21，23： | 20 |
| 2 | Oxidative stress, antioxidants and intestinal calcium absorption显示文摘The disequilibrium between the production of reactive oxygen(ROS) and nitrogen(RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products of electron transport chain. Most of the time the intestine responds adequately against the oxidative stress, but with aging or under conditions that exacerbate the ROS and/or RNS production, the defenses are not enough and contribute to developing intestinal pathologies. The endogenous antioxidant defense system in gut includes glutathione(GSH) and GSH-dependent enzymes as major components. When the ROS and/or RNS production is exacerbated, oxidative stress occurs and the intestinal Ca2+ absorption is inhibited. GSH depleting drugs such as DLbuthionine-S,R-sulfoximine, menadione and sodium deoxycholate inhibit the Ca2+ transport from lumen to blood by alteration in the protein expression and/or activity of molecules involved in the Ca2+ transcellular and paracellular pathways through mechanisms of oxidative stress, apoptosis and/or autophagy. Quercetin, melatonin, lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant, anti-apoptotic and/or anti-autophagic properties. Therefore, they may become drugs of choice for treatment of deteriorated intestinal Ca2+ absorption under oxidant conditions such as aging, diabetes, gut inflammation and other intestinal disorders. | Gabriela Diaz de Barboza Solange Guizzardi Luciana Moine Nori Tolosa de Talamoni | 2017 | World Journal of Gastroenterology2017，23，16： | 18 |
| 3 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 4 | Cryptogenic cirrhosis in the region where obesity is not prevalent显示文摘瞄准:最近的研究证明了肥胖是起因不明的肝硬化(CC ) 和非酒精的 steatohepatitis 的普通特征。然而,几乎在肥胖不是流行的区域的 CC 上没有很少信息。方法:CC 的临床的特征,和肝相关的病态和死亡在肥胖的流行是低的日本被分析。在 652 个肝脏硬化症的病人之中,我们与 CC 识别了 29 个病人(4.4%) 。这些,被跟随在上面因为超过 6 个月在盒子控制被比较的 24 个 CC 病人与年龄学习 -- ,性别 -- ,并且病毒的病原学的孩子呸匹配分数的控制有肝硬化。结果:肥胖(BMI>or=25 kg/m (2 )) ,糖尿病,和 hypertriglyceridemia 是更经常的,并且内脏的胖区域比在控制在 CC 病人是更大的。抗胰岛素性的索引更高,浆液 aminotransferase 层次比在控制在 CC 病人是更低的。逻辑回归分析作为 CC 的独立预言者识别了提高的血红素 A1c, BMI>or=25 kg/m (2 ) ,和正常 aminotransferase 层次。Kaplan-Meier 分析与在那些组之间的肝相关的病态的类似的累积概率相对照比在控制在 CC 表明了肝细胞癌和更高的幸存率的更低的出现。结论:CC 更经常甚至在肥胖不是流行的区域与控制相比与非酒精的 steatohepatitis 暗示的临床的特征介绍。肝细胞癌和更高的幸存率的更低的出现可以作为与病毒的肝硬化相比在 CC 显示一堂懒惰临床的功课。 | Hideyuki Kojima Shinya Sakurai Masahiko Matsumura Norie Umemoto Masahito Uemura Hiroyo Morimoto Yasuhiro Tamagawa Hiroshi Fukui | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 5 | Natural and artificial atoms for quantum computation显示文摘 | Iulia Buluta Sahel Ashhab Franco Nori | 2011 | Reports on Progress in Physics2011，，10： | 2 |
| 6 | Consumption of n-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma显示文摘 | Norie Sawada Manami Inoue Motoki Iwasaki Shizuka Sasazuki Taichi Shimazu Taiki Yamaji Ribeka Takachi Yasuhito Tanaka Masashi Mizokami Shoichiro Tsugane | 2012 | Gastroenterology2012，，7： | 2 |
| 7 | Multiple wafer annealing of undoped SI LEC GaAs and its effect on the wafer quality 显示文摘 | Nori M Kano G Inoue T | 1990 | Semi-Insulating Ⅲ-Ⅴ Materials1990，，： | 2 |
| 8 | Obstructive jaundice caused by secondary pancreatic tumor from malignant solitary fibrous tumor of pleura:A case report显示文摘对胸膜的恶意的独居的含纤维的肿瘤的手术后的双边的多重肺转移的全身的化疗上的一个 77 岁的人受不了瘙痒和黄疸。血检查显示出肝胆管酶的提高的层次。腹的计算断层摄影术在胰腺的头与外部改进显示出一个肿瘤,与 intra 肝、额外肝的胆汁管的膨胀伴随了。他作为把妨碍的黄疸被一个胰腺的头肿瘤引起了被诊断。胰腺的头肿瘤大概作为胸膜的恶意的独居的含纤维的肿瘤的转移被诊断,因为腹的 CT 上的胰腺的头肿瘤上的调查结果类似于胸膜的恶意的独居的含纤维的肿瘤的主要的肺损害上的那些。胰腺的肿瘤在胆总管的劣等的部分在金属性的斯滕特氏印模膏的培植以后很快成长了。病人死于肺的癌性淋巴管炎。尸体揭示了从胰腺的头传播了到肝的核的一个肿瘤。用显微镜,和骨胶原免职展出原子 atypicality 或分割的塑造锭子的房间被观察。Immunohistochemically 胰腺的头肿瘤房间为 alpha 光滑的肌肉肌动朊(alpha-SMA ) 或 CD117 染色是否定的,但是为 vimentin, CD34 和 CD99 积极。这些调查结果与胸膜的恶意的独居的含纤维的肿瘤上的那些一致。我们报导一个第二等的胰腺的肿瘤从胸膜的恶意的独居的含纤维的肿瘤引起的妨碍的黄疸的第一个案例。 | Norie Yamada Chiaki Okuse Masahito Nomoto Mayu Orita Yoshiki Katakura Toshiya Ishii Takuo Shinmyo Hiroaki Osada Ichiro Maeda Hiroshi Yotsuyanagi Michihiro Suzuki Fumio Itoh | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 9 | Neurorehabilitation using a voluntary driven exoskeletal robot improves trunk function in patients with chronic spinal cord injury: a single-arm study显示文摘Body weight-supported treadmill training with the voluntary driven exoskeleton(VDE-BWSTT) has been shown to improve the gait function of patients with chronic spinal cord injury. However, little is known whether VDE-BWSTT can effectively improve the trunk function of patients with chronic spinal cord injury. In this open-label, single-arm study, nine patients with chronic spinal cord injury at the cervical or thoracic level(six males and three females, aged 37.8 ± 15.6 years, and time since injury 51.1 ± 31.8 months) who underwent outpatient VDE-BWSTT training program at Keio University Hospital, Japan from September 2017 to March 2019 were included. All patients underwent twenty 60-minute gait training sessions using VDE. Trunk muscular strength, i.e., the maximum force against which patient could maintain a sitting posture without any support, was evaluated in four directions: anterior, posterior, and lateral(right and left) after 10 and 20 training sessions. After intervention, lateral muscular strength significantly improved. In addition, a significant positive correlation was detected between the change in lateral trunk muscular strength after 20 training sessions relative to baseline and gait speed. The change in trunk muscular strength after 20 training sessions relative to baseline was greatly correlated with patient age. This suggests that older adult patients with chronic spinal cord injury achieved a greater improvement in trunk muscle strength following VDE-BWSTT. All these findings suggest that VDE-BWSTT can improve the trunk function of patients with chronic spinal cord injury and the effect might be greater in older adult patients. The study was approved by the Keio University of Medicine Ethics Committee(IRB No. 20150355-3) on September 26, 2017. | Hiroki Okawara Syoichi Tashiro Tomonori Sawada Keiko Sugai Kohei Matsubayashi Michiyuki Kawakami Satoshi Nori Osahiko Tsuji Narihito Nagoshi Morio Matsumoto Masaya Nakamura | 2022 | Neural Regeneration Research2022，17，2： | 2 |
| 10 | 社区自然资源管理方法的推广进展分析显示文摘通过对社区自然资源管理方法推广的进展进行了调查 ,了解到推广的进展情况及一些值得注意的问题。对问题进行了分析 。 | 袁涓文 Norie Garcia 韦小平 欧国武 | 2004 | 贵州农业科学2004，32，5： | 2 |
| 11 | Autologous platelet transfusion in patients receiving high-dose chemotherapy and circulating progenitor cell transplansplantation for stage Ⅱ/Ⅲ breast cancer显示文摘 | Pedrazzoli P Noris P Perotti C | 1998 | Hamtologica1998，83，3： | 1 |
| 12 | Mesencephalic neural stem (Progenitor) cells develop to dopaminergic neurons more strongly in doparmine-depleted striatum than in intact striatum显示文摘 | Hitoo N Hideki H Norie T | 2000 | Exp Neurology2000，164，： | 1 |
| 13 | Cell death in-duced by baiculein in human hepatocellular carcinoma cell lines 显示文摘 | Yuko M S Norie K K Shuji T | 1996 | Jpn J Cancer Res1996，87，： | 1 |
| 14 | Treatment of primary unresectable carcinoma of the pancreas with 12125 implantation 显示文摘 | Peterz T Nori D Hilaris B | 1989 | Int J Radiat Oncol Biol Phys1989，17，93： | 1 |
| 15 | Propionyl-L-carnitine prevents renal function deterioration due to ischemia-reperfusion 显示文摘 | Mister M Noris M Szymczuk J | 2002 | Kidney Int2002，61，3： | 1 |
| 16 | Experimental and computational investigation of flow and thermal behavior of a mechanical seal显示文摘 | Parviz Merati Nori Aki Okita | 1999 | Tribology Tanscations1999，42，4： | 1 |
| 17 | Strategic Investment and Technology Spillovers显示文摘 | NORI TARUI AND STEPHEN POLASKY.Environmental Regulation with Learning | | 0，，： | 1 |
| 18 | Omicron targets upper airways in pediatrics,elderly and unvaccinated population显示文摘Omicron,a severe acute respiratory syndrome coronavirus-2 variant,has spread around the globe,causing dramatic increases in infection rates.Viral mutant antigens were responsible for the strong infectivity,fast replication,and high reinfection rates reported from all ages.Omicron causes clinical symptoms mostly related to the upper respiratory tract with minimal symptoms from the lower respiratory tract besides an urgent presentation of cases that resembled a fatal illness,epiglottitis.Not to mention the long coronavirus disease 2019,which rises exponentially in the Omicrons era.Apparently,the disease has a less aggressive course than earlier variants with lower death rates;however,the infection is not trivial.Severe infection was raised among pediatrics,unvaccinated,and the elderly.Complete vaccine protection is urgently needed to protect the most vulnerable community members.Additionally,self-protective strategies such as wearing a mask and safe social distancing cannot be omitted. | Wassan Nori Muna Abdul Ghani Zghair | 2022 | World Journal of Clinical Cases2022，10，32： | 1 |
| 19 | Midterm results of stemt-gra ft repair of acute and chronic aortie dissection with descending tear:The compl ication-Specific approach显示文摘 | Nori YK Takatsugu S Tadanori H | 2002 | J Thorac Cardiovasc Surg2002，124，： | 1 |
| 20 | Treatment of primary unresectable carcinoma of the pancreas with I-125 implantation显示文摘 | Peretz T Nori D Hilaris B | 1989 | Int J Radiat Oncol Biol Phys1989，17，5： | 1 |
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