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| 1 | Anterior muscle sparing approach for total hip arthroplasty显示文摘The purpose of this review is to examine the validity of positive claims regarding the direct anterior approach(DAA) with a fracture table for total hip arthroplasty. Recent literature regarding the DAA was searched and specific claims investigated including improved early outcomes, speed of recovery, component placement, dislocation rates, and complication rates. Recent literature is positive regarding the effects of total hip arthroplasty with the anterior approach. While the data is not definitive at present, patients receiving the anterior approach for total hip arthroplasty tend to recover more quickly and have improved early outcomes. Component placement with the anterior approach is more often in the 'safe zone' than with other approaches. Dislocation rates tend to be less than 1% with the anterior approach. Complication rates vary widely in the published literature. A possible explanation is that the varianceis due to surgeon and institutional experience with the anterior approach procedure. Concerns remain regarding the 'learning curve' for both surgeons and institutions. In conclusion, it is not a matter of should this approach be used, but how should it be implemented. | Joseph T Moskal Susan G Capps John A Scanelli | 2013 | World Journal of Orthopedics2013，4，1： | 47 |
| 2 | 食管和贲门癌前病变癌基因c-erbB_2、c-myc和cyclin D_1的表达研究显示文摘为了解食管和贲门癌变的分子生物学发生基础,采用免疫组化技术测定人食管和贲门正常上皮和癌前病变组织的癌基因蛋白c-erbB2,c-myc和cyclinD1的表达状况。研究对象来自食管癌高发区河南辉县。结果:在食管,未观察到c-erbB2的阳性表达(0/54);而c-myc和cyclinD1的阳性表达率分别为25%(6/24)和82%(94/115)。贲门上皮c-erbB2和c-myc的阳性表达率分别为73%(16/26)和78%(31/40),均明显高于食管组织的表达。贲门组织cyclinD1的阳性表达率为78%(31/40),但是,随着贲门上皮病变加重,cyclinD1的阳性表达率呈现下降趋势。提示同一地区食管和贲门癌前病变发生存在不同的分子学改变;食管和贲门癌变的不同阶段可能由多种癌基因参与作用;c-erbB2可能是贲门癌变的重要分子学变化。 | 王立东 周琦 李永欣 邢莹 刘保池 裘宋良 Susan Goldstein Stephenie T Shi Jun Y.Hong Chung S.Yang | 1995 | 河南医科大学学报1995，30，2： | 7 |
| 3 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 4 | Smoking in schizophrenic patients:A critique of the selfmedication hypothesis显示文摘A common remark among laypeople, and notably also among mental health workers, is that individuals with mental illnesses use drugs as self-medication to allay clinical symptoms and the side effects of drug treatments. Roots of the self-medication concept in psychiatry date back at least to the 1980 s. Observations that rates of smokers in schizophrenic patients are multiple times the rates for regular smoking in the general population, as well as those with other disorders, proved particularly tempting for a self-medication explanation. Additional evidence came from experiments with animal models exposed to nicotine and the identification of neurobiological mechanisms suggesting self-medication with smoking is a plausible idea. More recently, results from studies comparing smoking and non-smoking schizophrenic patients have led to the questioning of the self-medication hypothesis. Closer examination of the literature points to the possibility that smoking is less beneficial on schizophrenic symptomology than generally assumed while clearly increasing the risk of cancer and other smoking-related diseases responsible for early mortality. It is a good time to examine the evidence for the self-medication concept as it relates to smoking. Our approach is to focus on data addressing direct or implied predictions of the hypothesis in schizophrenic smokers. | Francesca Manzella Susan E Maloney George T Taylor | 2015 | World Journal of Psychiatry2015，5，1： | 4 |
| 5 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 6 | 新致病基因在颅缝早闭Crouzon综合征中的初步机制研究显示文摘目的研究Rbp4(Retinol binding protein 4)、Gpc3(Glypican family of growth factor binding protein 3)、C1qtnf3(Collagenous repeat-containing sequence of 26 KDa protein)等新致病基因在颅缝早闭症中的发病机制,为疾病非手术治疗奠定理论基础。方法以Crouzon综合征Fgfr2cC342Y/+小鼠为实验模型,应用MicroCT和组织学染色,研究小鼠颅缝闭合模式;以Fgfr2cC342Y/+模型,RT-qPCR研究Rbp4、Gpc3、C1qtnf3等新致病基因的表达差异,初步探讨其在颅缝闭合过程中的调控作用;以体外培养的Fgfr2cC342Y/+小鼠颅缝细胞为模型,研究基因突变动物细胞增殖与代谢改变。结果获得Fgfr2cC342Y/+小鼠后额缝、冠状缝、人字缝、矢状缝等颅缝闭合模式,随颅骨发育、颅缝闭合,OC(Osteocalcin)、ALP(Alkalinephosphatase)表达增加,目的基因Rbp4、Gpc3、C1qtnf3表达下降,Msx2(Muscle segment homeobox gene 2)表达增加,杂合子与野生型小鼠之间均存在显著统计学差异,与前期人颅缝组织Microarray研究结果一致。Gpc1(Glypican family ofgrowth factor binding protein 1)、FliI(Flightless I)在颅缝闭合中的表达较恒定,野生型与杂合子之间未见明显统计学差异。体外培养Fgfr2cC342Y/+小鼠颅缝细胞,CellTiter96 MTS和Quant-iT Picogreen dsDNA细胞增殖与代谢分析结果显示,Fgfr2功能获得性突变可促进冠状缝细胞的增殖,从而导致成骨增加,颅缝早闭。结论 Fgfr2cC342Y/+模型新致病基因表达趋势与前期人颅缝组织Microarray研究结果一致,Rbp4、Gpc3、C1qtnf3可能在颅缝早闭中具重要调控作用。 | 杨娴娴 Jodie T Hatfield Susan J Hinze 穆雄铮 Peter J Anderson Barry C Powell | 2012 | 组织工程与重建外科杂志2012，8，5： | 3 |
| 7 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 8 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 9 | The influence of EDDS on the uptake of heavy metal in hydroponically grown sunflowers显示文摘 | Susan T Rainer S Bemd N | 2006 | Chemosphere2006，62，： | 1 |
| 10 | Short Report: Identification of Adenoviruses in Fecal Specimens from Wild Chimpanzees (Pan trogylodytes schweinfurthli ) in Western Tanzania显示文摘 | Suxiang T Jatinder S Susan R | 2010 | Am J Trop Med Hyg2010，82，5： | 1 |
| 11 | Autism显示文摘 | Susan E Levy David S Mandell Robert T Schultz | 2009 | The Lancet2009，，9701： | 1 |
| 12 | The role of plants in ecologically engineered wastewater treatment systems显示文摘 | Susan B P John M T | 1996 | Ecol Eng1996，6，1： | 1 |
| 13 | The Impact of E-commerce on Supply Chain Relationships 显示文摘 | Susan L Golicic Donna F Davis Teresa M McCar-thy John T Mentzer | 2002 | International Journal of Physical Distribution & Logistics Management2002，32，910： | 1 |
| 14 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | Susane E L Michael K T Anthony P J T | 1985 | J General Microbiology1985，131，： | 1 |
| 15 | Nutrient intake and risk of subtypes of esophageal and gastric cancer显示文摘 | Susan T Mayne 2 Harvey A Risch Robert Dubrow | 2001 | Cancer Epidemiol Biomarkers Prey2001，10，10： | 1 |
| 16 | Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells显示文摘 | Nalinie S W Tissa T M Susan M D | 2009 | Nucleic Acids Res2009，37，8： | 1 |
| 17 | The wing in yeast heat shock transcription factor(HSF) DNA-binding domain is required for full activity 显示文摘 | MARCOv P C SUSAN T H CELIA J H | 2001 | Nucleic Acids Res2001，29，8： | 1 |
| 18 | Extraction of heavy metal from soil using biodegradable chelating agents显示文摘 | Susan T Karin B Roland M | 2004 | Environ Sci Technol2004，38，3： | 1 |
| 19 | Column extraction of heavy metals from soils using biodegradable chelating agent EDDS显示文摘 | Lukas H Susan T Rainer S | 2005 | Environ Sci Technol2005，39，17： | 1 |
| 20 | Enhanced cofermentation of glucose and xylose by recombinantSaccharomyces yeast strains in batch and continuous operating modes显示文摘 | t SUSAN T TOON GEORGE P PHILIPPIDIS NANCY W Y HO | 1997 | Applied Bio- chemistry and Biotechnology1997，6365，1： | 1 |
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