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| 1 | Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats显示文摘AIM To explore the kinetic changes in plasma D (-)lactate and lipopolysaccharide ( LPS ) levels, and investigate whether D (-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/reperfusion, burn, and acute necrotizing pancreatitis (ANP).METHODS Three models were developed in rats:gut ischemia/reperfusion obtained by one hour of superior severe burn injury created by 30% of total body surface induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct.Plasma levels of D( - )-lactate in systemic circulation and LPS in portal circulation were measured by enzymaticspectrophotometric method and limulus amebocyte lysate (LAL) test kit, respectively. Tissue samples of intestine were taken for histological analysis.RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D( - )lactate and LPS levels, and there was a significant correlation between the plasma D( - )-lactate and LPS (r =0.719, P<0.05). The plasma concentrations of D(-)lactate and LPS increased significantly at 6 h postburn,and there was also a remarkable correlation between them (r = 0.877, P < 0.01). D ( - )-lactate and LPS levels elevated significantly at 2 h after ANP, with a similar significant correlation between the two levels (r-0.798,P < 0.01 ). The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups.CONCLUSION The changes of plasma D( - )-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood. The measurement of plasma D (-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. | Xiao-Qing Sun Xiao-Bing Fu Rong-Zhan Yi Lü Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China | 2001 | World Journal of Gastroenterology2001，7，4： | 56 |
| 2 | The experimental study of genetic engineering human neural stem cells mediated by lentivirus to express multigene显示文摘 | Cai PQ Tang X Lin YQ Martin O Sun GY Xu L Yang YK Zhou TH | 2006 | 中国生物学文摘2006，20，5： | 6 |
| 3 | Obesitysuppresses circulating level and function of endothelialprogenitor cells and heart function显示文摘 | Tsai TH Chai HT Sun CK Yen CH Leu S Chen YL | 2012 | Journal ofTranslational Medicine2012，10，1： | 1 |
| 4 | Small heat shock proteins : mole cular structure and chaperone function显示文摘 | Sun Y MacRae TH | 2005 | Cell Mol Life Sci2005，62，21： | 1 |
| 5 | Small heat shock proteins: molecular structureand chaperone function 显示文摘 | Sun Y Macrae TH | 2005 | Cell Mol Life Sci2005，62，21： | 1 |
| 6 | Kinetic studies on rat liver microsomal glutathione transferase: consequences of activation显示文摘 | Piemonte F Mosialou E Weinander R Sun TH Lundqvist G | 1995 | Biochim Biophys Acta1995，1247，2： | 1 |
| 7 | How far can the radiation dose be lowered in head CT with iterative reconstruction? Analysis of imaging quality and diagnostic accuracy显示文摘 | Wu TH Hung SC Sun JY | 2013 | Eur Radiol2013，23，9： | 1 |
| 8 | RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling 显示文摘 | Sun X Kahenbronn KM Steinberg TH | 2005 | Mol Pharmacol2005，67，3： | 1 |
| 9 | Upper thoracic sympathectomy for axillary osmidrosis or bromidrosis显示文摘 | Kao TH Pan HC Sun MH | 2004 | J Clin Neurosci2004，11，7： | 1 |
| 10 | Comparison of 30-day mortality between anterior-wall versus inferior-wall ST- segment elevation myocardial infarction complicated by cardiogenic shock in patients undergoing primary coronary angioplasty显示文摘 | Tsai TH Chai HT Sun CK | 2010 | Cardiology2010，116，2： | 1 |
| 11 | Diagnostic pitfalls of nonsecretory myeloma manifesting as multiple foci of periosse- ous plasmacytomas 显示文摘 | Chen LP Sun TH Hsieh PP | 2011 | J Chin Med Assoc2011，74，10： | 1 |
| 12 | Application and verification of a fractal approach to landslide susceptibility mapping 显示文摘 | Li C J Ma TH Sun LL | 2012 | Natural Hazards2012，61，： | 1 |
| 13 | Presentation of lnterleukin-12/23 receptor β1 deficiency with various clinical symptoms of salmonella infections 显示文摘 | Ozden Sanal Tuba Turul Tijtske De Boer Van de vosse E Yalcin I Tezcan I Sun C Memis L Otten hoff TH E:rsoy F | 2006 | J Clin Immunnl2006，26，1： | 1 |
| 14 | Upper thoraciu sympathectomy for axillary osmidrosis or bromidrosis显示文摘 | Kao TH Pan HC Sun MH eI al | 2004 | J Clin Neurosci2004，11，7： | 1 |
| 15 | Effects of hepatitis B virus S protein on human sperm function显示文摘 | Zhou XL Sun PN Huang TH | 2009 | Hum Reprod2009，24，7： | 1 |
| 16 | Small heat shock proteins : molecular structure and chaperone function 显示文摘 | Sun Y MacRae TH | 2005 | Cell Mol Life Sci2005，62，21： | 1 |
| 17 | Damage mechanics based predictions of creep growth in 316 stainless steel显示文摘 | Hyde CJ Hyde TH Sun W | 2010 | Engineering Fracture Mechanics2010，77，： | 1 |
| 18 | T cell energy, exhaustion,senescence and sternness in the tumor microenvironment 显示文摘 | Crespo J Sun H Welling TH | 2013 | Curr Opin Immuno12013，19，3： | 1 |
| 19 | Small heat shock proteins: molecular structure and chaperone function 显示文摘 | Sun Y MacRae TH | 2005 | Cellular Molecular Life Sciences2005，62，： | 1 |
| 20 | The gennme of the mesopolyploid crop species Brassica rapa 显示文摘 | Wang X Wang H Wang J Sun R Wu J Liu S Bai Y Mun JH Bancroft I Cheng F Huang S Li X Hua W Wang J Wang X Freeling M Pires JC Paterson AH Chalhoub B Wang B Hayward A Sharpe AG Park BS Weisshaar B Liu B Li B Liu B Tong C Song C Duran C Peng C Geng C Koh C Lin C Edwards D Mu D Shen D Soumpourou E Li F Fraser F Conant G Lassalle G King G J Bonnema G Tang H Wang H Belcram H Zhou H Hirakawa H Abe I-I Guo H Wang H Jin H Parkin IA Batley J Kim JS Just J l i J Xu J Deng J Kim JA Li J Yu J Meng J Wang J Min J Poulain J Wang J Hatakeyama K Wu K Wang L Fang L Trick M Links MG Zhao M Jin M Ramchiary N Drou N Berkman PJ Cai Q Huang Q Li R Tabata S Cheng S Zhang S Zhang S Huang S Sato S Sun S Kwon SJ Choi SR Lee TH Fan W Zhao X Tan X Xu X Wang Y Qiu Y Yin Y l i Y Du Y Liao Y Lira Y Narusaka Y Wang Y Wang Z Li Z Wang Z Xiong Z Zhang Z Brassica rapa Genome Sequencing Project Consortium | 2011 | Nature Genetics2011，43，10： | 1 |
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