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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Choline- modulated arsenic trioxide-induced prolongation of cardiac repolarization in guinea-pig 显示文摘 | Sun HL Chu WF Dong DL | 2006 | Basic Clin Pharmacol Toxicol2006，98，4： | 1 |
| 3 | Perspectives on the cell biology underlying Alzheimer's disease and the potential for therapy 显示文摘 | Sun MK Mkon DL | 2001 | Int Arch Biosci2001，，： | 1 |
| 4 | Excitotoxic effect of kainic acid on chicken otoacoustic emissions and cochlear potentials显示文摘 | Sun H Salvi RJ Ding DL | 2000 | J Acoust Soc Am2000，107，： | 1 |
| 5 | Intragenomic heterogeneity of 16S rRNA genes causes overestimation of prokaryotic diversity显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied and Environmental Microbiology2013，79，19： | 1 |
| 6 | CRIPT03 , a presumed pseudo-gene ,is expressed in cancer 显示文摘 | Sun C Orozco 0 Olson DL | 2008 | Biochem Biophys Res Commun2008，377，1： | 1 |
| 7 | Effect and mechanism of cantharides vesiculation moxibustion on hematopoietic function inmice treated with cyclophosphamide显示文摘 | Sun DL Chen HP Wu HG et a1 | 2011 | J Acupunct Tuina Sci2011，9，6： | 1 |
| 8 | In vivo expression of Ton-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients显示文摘 | Sun Y Guo QM Liu DL | 2010 | Oral Dis2010，16，4： | 1 |
| 9 | Effect of moxibustion therapy pluscupping on exercise-induced fatigue in athletes 显示文摘 | Sun DL Zhang Y Chen DL | 2012 | J Acupunct TuinaSci2012，10，5： | 1 |
| 10 | PKCE activa- tion prevents synaptic loss, A, elevation, and cog- nitive deficits in Alzheimer's disease transgenic mice显示文摘 | Hongpaisan J Sun MK Alkon DL | 2011 | J Neurosci2011，31，2： | 1 |
| 11 | Association of Adam33 polymorphisms with childhood asthma in a northern Chinese population显示文摘 | QU SQ SUN DL WANG Y | 2011 | ExpMolPathol2011，91，3： | 1 |
| 12 | Silencing of Regiv by shRNA causes the loss of sternness properties of cancer stem cells in MKN45 gastric cancer cells显示文摘 | ZHOU W SUN M WANG DL | 2013 | Oncol Rep2013，30，6： | 1 |
| 13 | Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China显示文摘 | Li Y Sun DL Duan YN | 2010 | Mol Biol Rep2010，37，1： | 1 |
| 14 | Niemann-Pick C Variant Detection by Altered Sphingolipid Trafficking and Correlation with Mutations within a Specific Domain of NPC1显示文摘 | SUN X MARKS DL PARK WD | 2001 | Am J Hum Genet(S0002-9297)2001，68，： | 1 |
| 15 | Phase change heat transfer simulation for boiling bubbles arising from a vapor film by VOSET method 显示文摘 | GUODZ SUN DL LI Z Y | 2011 | Numerical Heat Transfer: Part A2011，59，11： | 1 |
| 16 | Stereoselective protein binding of te- trahydropalmatine enantiomers in human plasma, HSA, and AGP, but not in rat plasma显示文摘 | Sun DL Huang SD Wu PS | 2010 | Cbirality2010，22，6： | 1 |
| 17 | Stereoselective metabolism of tetrah'/- dropalmatine enantiomers in rat liver microsomes 显示文摘 | Zhao M Li LP Sun DL | 2012 | Chirality2012，24，5： | 1 |
| 18 | Effects of coencapsulation of hepa-tocytes with adipose-derived stem cells in the treatment of ratswith acute - on - chronic liver failure 显示文摘 | Zhang Y Chen XM Sun DL | 2014 | Int J Artif Organs2014，37，2： | 1 |
| 19 | Intragenomicheterogeneity of 16S rRNA genes causes overestimation ofprokaryotic diversity显示文摘 | Sun DL Jiang X Wu QL | 2013 | Applied and EnvironmentalMicrobiology2013，79，19： | 1 |
| 20 | Expression of long non-coding ribonucleic acid metastasis-associated lung ad transcript-1 is eorre- lated with progress and apoptosis of laryngeal显示文摘 | Feng LT Y Sun DL Wu T | 2012 | 4( 2 ) : 46-532012，4，2： | 1 |
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