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| 1 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 2 | Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.显示文摘 | Zhang JD Xu Z Cao YB Chen HS Yan L An MM Gao PH Wang Y Jia XM Jiang YY | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 3 | Effects of HBV gene variations on disease development and antiviral therapy for patients with chronic hepatitis B显示文摘Viral variation may change pathogenicity, escape immunity, lead to persistence infection, and cause drug resistance against antiviral therapy. This study was undertaken to investigate the effects of HBV gene variation on the progression of disease and on the efficacy of antiviral therapy for patients with chronic hepatitis B(CHB). METHODS:Hepatitis B virus (HBV) gene mutational sites were detected using gene chip in selected hepatitis B patients. RESULTS:In the patients HBeAg did not show serologic conversion or HBeAg(-)/anti-HBe(+), but their HBV DNA remained positive 24 weeks after α-interferon therapy, which was associated with mutations of nt1896, nt1814, nt1762 and nt1764. In the patients, that HBV DNA levels decreased or were undetectable, but rebounded later after antiviral therapy by lamivudine was associated with mutations of aa528 and(or) aa552(i.e.YMDD mutation), which resulted in lamivudine-resistance. YMDD mutation was prone to occur 52 weeks after lamivudine therapy in some chronic hepatitis B patients (26.4%). Nt1896 mutation was common in most chronic hepatitis B patients (68.5%). Chronic severe hepatitis, cirrhosis, and primary liver carcinoma were related to the mutations of nt1896, nt1762 and nt1764. CONCLUSIONS:HBV gene mutations could aggravate patient’s condition and affect the efficacy of antiviral therapy. The regular detection of HBV gene mutation is helpful for identification of disease prognosis and adjustment of therapeutic strategy. | Shenzhen Eastlake Hospital, Shenzhen 518020, China (Chen JY) and National Key Laboratory of Virology (Wuhan University) Department of Infectious Diseases, Renmin Hospital, Wuhan University, Wuhan 430060, China(Wang LW, Sun XM and Gong ZJ) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 8 |
| 4 | 相关性和一致性:这对相仿概念和测量方法的回顾与阐明(英文)显示文摘一致性(agreement)和相关性(correlation)是两个广泛使用的概念,用来评估变量之间的关联。虽然二者相似且相关,但是它们代表关联完全不同的概念。评估变量之间的一致性假设变量测量的是相同的结构,而在变量测量完全不同的结构时也可以评估它们之间的相关性。这种概念上的差异就要求使用不同的统计方法,并且当评估一致性或相关性时,统计方法根据数据的分布和研究者的兴趣可能会有所不同。例如,Pearson相关性,作为评估连续变量之间相关性的一种普遍测量方法,只有用于符合线性关系的变量时才能提供有用的信息;当用于不符合线性关系的变量时就无法提供准确信息甚至会产生误导。同样地,内部相关性,作为一种评估连续变量之间一致性的常用方法,如果一致性不好的实质正好是研究兴趣所在,那么该测量就不能为研究者提供充分的信息。本报告回顾了一致性和相关性的概念,并讨论了几种常用方法在应用中的差异。 | Liu JY Tang W Chen GQ Lu Y Feng CY Tu XM | 2016 | 上海精神医学2016，28，2： | 6 |
| 5 | Comparison of gene expression between normalcolon mucosa and colon carcinoma by means of messenger RNA differential display显示文摘 | Wang L Lu W Chen YG Zhou XM Gu JR | 1999 | World Journal of Gastroenterology1999，5，6： | 4 |
| 6 | Enhancement of riboflavin production by overexpression of acetolactate synthase in a pta mutant of Bacillus subtilis显示文摘 | Zhu, YB Chen, X Chen, T Zhao, XM | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 7 | Human intestinal and biliary cryptosporidiosis显示文摘 | Chen XM LaRusso NF | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 8 | Transvaginal, ultrasoundguided ovarian, interstitial laser treatment in anovnlatory women with clomephene-resistant polycystic ovary syndrome显示文摘 | Zhu WJ Li XM Chen XM | 2006 | BJOG2006，113，7： | 1 |
| 9 | High-yield production of lutein by the green microalga Chlorella protothecoides in heterotrophic fed-batch culture显示文摘 | SHI XM JIANG Y CHEN F | 2002 | Biotecbnology Progress2002，18，4： | 1 |
| 10 | Tachyplesin activates the classic complement pathway to kill tumor cells显示文摘 | Chen J Xu XM Underhill CB | 2005 | Cancer Res2005，65，11： | 1 |
| 11 | Fuzzy- based methodology for performance assessment of emergency planning and its applicafion显示文摘 | Chen GH Zhang XM | 2009 | Journal of Loss Prevention in the Process Industries2009，22，2： | 1 |
| 12 | Key enzymes of triterpenoid saponin biosynthesis and the induction of their activities and gene expressions in plants显示文摘 | Zhao CL Cui XM Chen YP | 2010 | Nat Prod Commun2010，5，7： | 1 |
| 13 | Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung显示文摘 | Chen YH Wang PP Wang XM | 2011 | Cytokine2011，53，3： | 1 |
| 14 | Ethanol extract from Epimedium brevicornum attenuates left ventricular dysfunction and cardiac remodeling through down-regulating matrix metalloproteinase-2 and -9 activity and myocardial apoptosis显示文摘 | Song YH Li BS Chen XM | 2008 | International Journal of Molecular Medicine2008，21，1： | 1 |
| 15 | Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968DI in patients with advanced malignancies 显示文摘 | Li J Zhao XM Chen L | 2010 | BMC Cancer2010，10，5： | 1 |
| 16 | CTGF and chronic kidney fibrosis显示文摘 | Chen XM Qi W Pollock CA | 2009 | Front Biosci( Schol Ed)2009，1，： | 1 |
| 17 | Methylprednisolone administration improves axonal regeneration into schwann cell grafts in transected adult rat thoracic spinal cord 显示文摘 | Chen A Xu XM Kleitman N | 1996 | Exp Neurol1996，138，： | 1 |
| 18 | The generation and inactivation mechanism of oxidation-reduction potential of electrolyzed oxidizing water显示文摘 | Liao LB Chen WM Xiao XM | 2007 | Journal of Food Engineering2007，78，： | 1 |
| 19 | Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults:the HUNT study显示文摘 | Mai XM Chen Y Camargo CA | 2012 | Am J Epidemiol2012，175，10： | 1 |
| 20 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development 显示文摘 | Chen XM 2004 | 2004 | Science2004，303，： | 1 |
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