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| 1 | Role of surgical resection for multiple hepatocellular carcinomas显示文摘AIM:To clarify the role of surgical resection for multiple hepatocellular carcinomas(HCCs)compared to transarterial chemoembolization(TACE)and liver transplantation(LT). METHODS:Among the HCC patients who were managed at Yonsei University Health System between January 2003 and December 2008,160 patients who met the following criteria were retrospectively enrolled:(1) two or three radiologically diagnosed HCCs;(2)no radiologic vascular invasion;(3)Child-Pugh class A;(4) main tumor smaller than 5 cm in diameter;and(5) platelet count greater than 50 000/mm3.Long-term outcomes were compared among the following three treatment modalities:surgical resection or combined radiofrequency ablation(RFA)(n=36),TACE(n=107), and LT(n=17).The survival curves were computed using the Kaplan-Meier method and compared with a log-rank test.To identify the patients who gained a survival benefit from surgical resection,we also investigated prognostic factors for survival following surgical resection.Multivariate analyses of the prognostic factors for survival were performed using the Cox proportional hazard model. RESULTS:The overall survival(OS)rate was significantly higher in the surgical resection group than in the TACE group(48.1%vs 28.9%at 5 years,P<0.005). LT had the best OS rate,which was better than that of the surgical resection group,although the difference was not statistically significant(80.2%vs 48.1%at 5 years,P=0.447).The disease-free survival rates were also significantly higher in the LT group than in the surgical resection group(88.2%vs 11.2%at 5 years, P<0.001).Liver cirrhosis was the only significant prognostic factor for poor OS after surgical resection. Clinical liver cirrhosis rates were 55.6%(20/36)in the resection group and 93.5%(100/107)in the TACE group.There were 19 major and 17 minor resections. En bloc resection was performed in 23 patients,multisite resection was performed in 5 patients,and combined resection with RFA was performed in 8 patients. In the TACE group,only 34 patients(31.8%)were recorded as having complete remission after primary TACE.Seventy-two patients(67.3%)were retreated with repeated TACE combined with other therapies. In patients who underwent surgical resection,the 16 patients who did not have cirrhosis had higher 5-year OS and disease-free survival rates than the 20 patients who had cirrhosis(80.8%vs 25.5%5-year OS rate, P=0.006;22.2%vs 0%5-year disease-free survival rate,P=0.048).Surgical resection in the 20 patients who had cirrhosis did not provide any survival benefit when compared with TACE(25.5%vs 24.7%5-year OS rate,P=0.225).Twenty-nine of the 36 patients who underwent surgical resection experienced recur-rence.Of the patients with cirrhosis,80%(16/20) were within the Milan criteria at the time of recurrence CONCLUSION:Among patients with two or three HCCs, no radiologic vascular invasion,and tumor diameters≤ 5 cm,surgical resection is recommended only in those without cirrhosis. | Sung Hoon Choi Gi Hong Choi Seung Up Kim Jun Yong Park Dong Jin Joo Man Ki Ju Myoung Soo Kim Jin Sub Choi Kwang Hyub Han Soon Il Kim | 2013 | World Journal of Gastroenterology2013，19，3： | 12 |
| 2 | High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy显示文摘AIM: To evaluate the prevalence and predictive factors of osteoporosis in patients with gastric adenocarcinoma after gastrectomy. METHODS: The study included 133 patients diagnosed with gastric adenocarcinoma but who did not undergo prior diagnostic work-up for osteoporosis. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) and vertebral deformity was assessed by plain X-rays. We evaluated the effects of age, sex, body mass index (BMI), anemia, back pain, vertebral deformity, tumor staging, reconstruction type, and past medical history to determine predictive factors of osteoporosis in these patients. RESULTS: The prevalence of osteoporosis in the lumbar spine was 38.3% (male, 28.9%; female, 54.0%), and 15.0% in the femoral neck (male, 10.8%; female, 22.0%). The vertebral deformity rate was 46.6% (male, 43.4%; female, 52.0%). Age, BMI and hemoglobin correlated with BMD (P < 0.01). In males, anemia and age > 64 years were independent predictive factors of osteoporosis in multivariate analysis. In females, back pain was an independent factor for osteoporosis. CONCLUSION: The results of this study revealed that prevalence of osteoporosis and vertebral bone deformity rate were high in gastric cancer patients, regardless of post-gastrectomy duration and operation type. Early diagnosis and a proper management plan must be established in these patients. | Jung Sub Lim Sang Bum Kim Ho-Yoon Bang Gi Jeong Cheon Jong-Inn Lee | 2007 | World Journal of Gastroenterology2007，13，48： | 3 |
| 3 | The Use of Adjusted Preoperative CA 19-9 to Predict the Recurrence of Resectable Pancreatic Cancer显示文摘 | Chang Moo Kang Jun Young Kim Gi Hong Choi Kyung Sik Kim Jin Sub Choi Woo Jung Lee Byong Ro Kim | 2007 | Journal of Surgical Research2007，，： | 3 |
| 4 | Outcome after curative resection for a huge (≥10 cm) hepatocellular carcinoma and prognostic significance of gross tumor classification显示文摘 | Gi Hong Choi Dai Hoon Han Dong Hyun Kim Sae Byeol Choi Chang Moo Kang Kyung Sik Kim Jin Sub Choi Young Nyun Park Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Woo Jung Lee | 2009 | The American Journal of Surgery2009，，5： | 2 |
| 5 | Human hepatocellular carcinomas with “Stemness”‐related marker expression: keratin 19 expression and a poor prognosis显示文摘 | Haeryoung Kim Gi Hong Choi Deuk Chae Na Ei Young Ahn Gwang Il Kim Jae Eun Lee Jai Young Cho Jeong Eun Yoo Jin Sub Choi Young Nyun Park | 2011 | Hepatology2011，，5： | 2 |
| 6 | Liver Resection for Bismuth Type I and Type II Hilar Cholangiocarcinoma显示文摘 | Jin Hong Lim Gi Hong Choi Sung Hoon Choi Kyung Sik Kim Jin Sub Choi Woo Jung Lee | 2013 | World Journal of Surgery2013，，4： | 1 |
| 7 | Association between cerebrospinal fluid SI00B protein and neuronal damage in patients with central nervous system infections 显示文摘 | Park JW Sub GI Shin HE | 2013 | Yonsei Med J2013，54，3： | 1 |
| 8 | Prognostic significance of the worst grade in hepatocellular carcinoma with heterogeneous histologic grades of differentiation显示文摘 | Dai Hoon Han Gi Hong Choi Kyung Sik Kim Jin Sub Choi Young Nyun Park Seung Up Kim Jun Yong Park Sang Hoon Ahn Kwang‐Hyub Han | 2013 | J Gastroenterol Hepatol2013，，8： | 1 |
| 9 | A Case of Robot-assisted Excision of Choledochal Cyst, Hepaticojejunostomy, and Extracorporeal Roux-en-y Anastomosis Using the da Vinci Surgical System显示文摘 | Chang Moo Kang Hoon Sang Chi Jun Young Kim Gi Hong Choi Kyung Sik Kim Jin Sub Choi Woo Jung Lee Byong Ro Kim | 2007 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2007，，6： | 1 |
| 10 | A practical approach to solving a newspaper logistics problem using a digital map显示文摘 | Sung Hun Song Kwan Suk Lee Gi Sub Kim | | 0，，： | 1 |
| 11 | Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials显示文摘Dear Editor Hepatocellular carcinoma(HCC)is among the most com-mon cancers worldwide,causing about 600,000 deaths annully[1].In HCC,stem cell-like characteristics,which drive early recurrence and therapy resistance,are major contributors to poor prognosis[2].In this current study,we integrated and analyzed gene expression data from human fetal liver cells and primary HCC tumors(n=1231)and.uncovered two clinically and biologically distinct hepatic stem cell(HS)subtypes,potential biomarkers associated with these subtypes,and a potential new therapeutic inter-vention for these subtypes. | Sung Hwan Lee Yun Seong Jeong Sunyoung Lee Bo Hwa Sohn Ho Kyoung Hwang Gi Hong Choi Chang Moo Kang Jin Sub Choi Woo Jung Lee Jae-Ho Cheong Hee Jin Jang Ahmed Kaseb Lewis Roberts Sun Young Yim Yun Shin Chun Ju-Seog Lee | 2022 | Cancer Communications2022，42，2： | 0 |
| 12 | Transanal excision of a malignant fibrous histiocytoma of anal canal:A case report and literature review显示文摘Malignant fibrous histiocytoma, which is composed of spindle-shaped cells arranged in a pleomorphic and storiform pattern, is rarely found in the colorectum. Although complete surgical excision remains the main stem of therapy, an optimal treatment strategy according to the stage has not been elucidated. We report a case of a 63-year-old woman with an ulcerative lesion in the anorectal junction and a final diagnosis of malignant fibrous histiocytoma. We introduced an access for transanal local excision and adjuvant radiotherapy because the patient refused abdominoperineal resection. No local recurrences or distant metastases were observed 15 mo after the operation. To our knowledge, this is the first case reported in the English literature of a malignant fibrous histiocytoma treated with the transana local excision and adjuvant radiotherapy. This report showed that this approach is selectively reserved for early-stage malignant fibrous histiocytoma and for those patients who refuse radical surgery because of the risk in a permanent colostomy. | Beom Gyu Kim In Taik Chang Jun Seok Park Yoo Shin Choi Gi Hyeon Kim Eon Sub Park Chang Hwan Choi | 2008 | World Journal of Gastroenterology2008，14，9： | 0 |
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