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| 1 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 2 | 叶酸与甲酰四氢叶酸用于减少甲氨蝶呤治疗副作用(摘要)显示文摘1 背景 甲氨蝶呤用于治疗许多风湿病,其短期疗效已被证实。但毒性使不少患者不能从中受益,其中叶酸缺乏可增加其毒性。类风湿关节炎患者常有叶酸缺乏,经甲氨蝶呤治疗后叶酸储备就进一步减少。甲氨蝶呤的胃肠道和血液学副作用都与叶酸缺乏有关,可以预见,叶酸补充疗法将有助改善低剂量甲氨蝶呤治疗的副作用。对此,已有不少试验开展,并提出不同的副作用减少率。 | Ortiz Z SheaB Suarez Almazor M Moher D Wells G Tugwell P 姚如愚 | 2001 | 循证医学2001，1，1： | 4 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | Comparative FT-IR study of the removal of octahedral cations and structural modifications during acid treatment of several silicates显示文摘 | VICENTE-RODRIGUEZ M A SUAREZ M BANARESMUNOZ M A | 1996 | Spectrochimica Acta Part A1996，52，： | 2 |
| 5 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 6 | Structural features of the avian influenza virus hemagglutinin that influence virulence 显示文摘 | Perdue M L Suarez D L | 2000 | Veterinary' Microbiology2000，74，： | 1 |
| 7 | Ni- tric oxide synthase inhibition and food intake effects on motivation to eat and in female mice 显示文摘 | MORLEY J E FARR S A SUAREZ M D | 1995 | Pharma- cology Biochemistry and Behavior1995，50，3： | 1 |
| 8 | Effect of age of feed restriction and microelement supplementa- tion to control ascites on production and carcass charac- teristics of broilers 显示文摘 | Camacho M A Suarez M E Herrera J G | 2004 | Poultry Science2004，，83： | 1 |
| 9 | A simple framework for examing the interannual variability of land surface moisture flux-es显示文摘 | Koster R D Suarez M J | | 0，，12： | 1 |
| 10 | Structural features of the avian influenza virus hemagglutinin that influence virulence 显示文摘 | Perdue M L Suarez D L | 2000 | Vet Mieobiol2000，74，12： | 1 |
| 11 | Isolation and characterization of PRA1,a trypsin -like protease from the biocontrol agent Trichoderma har-zianum CECT 2413 displaying nematicidal activity显示文摘 | SUAREZ B REY M CASTILLO P | 2004 | Appl Microbiol Bio-technol2004，，： | 1 |
| 12 | Design and Performance Analysis of a Massively Parallel Atmospheric General Circulation Model显示文摘 | Schaffer D S Suarez M J | 2000 | Scientific Programming2000，8，1： | 1 |
| 13 | Comparative FT-IR study of the removal of octahedral cations and structural modigications during acid treatment of several silicates显示文摘 | Vicente-Rodríguez M A Suarez M Banares-Munoz M A | 1996 | Spectrochimica Acta Part A1996，，52： | 1 |
| 14 | Value of the ankle-brachial index in cardiovascular risk stratification of patients without known atherotrom-hotic disease显示文摘 | MANZANO L MOSTAZA J M SUAREZ C | 2007 | Med Clin (Barc)2007，128，： | 1 |
| 15 | An effcient thermal infrared radiation parameterization for use in general circulation models 显示文摘 | Chou M D Suarez M J | 1994 | NASA Tech Memo 1046061994，3，： | 1 |
| 16 | Immediate andfollow-up findings after stentt treatment for severe eoareta- tion of aorta显示文摘 | Suarez de Lezo J Pan M Romero M | 1999 | Am J Cardiol1999，83，： | 1 |
| 17 | Balloon-expandable stent repair of severe coarctation of aorta显示文摘 | Suarez de Lezo J Pan M Romero M | 1995 | Am Heart J1995，129，： | 1 |
| 18 | Mannan-binding lectin pathway deficiencies and invasive fungal infections following allogeneie stem cell transplantation显示文摘 | Granell M Urbano-Ispizua A Suarez B | 2006 | Exp Hematol2006，34，10： | 1 |
| 19 | Dominant designs and the survival of firms显示文摘 | SUAREZ F F UTTERBACK J M | 1995 | Strategic Management Journal1995，16，6： | 1 |
| 20 | Evaluation of BTEX remediation by natural attenuation at a coastal facility 显示文摘 | Suarez M P Rifai H S | 2002 | Ground Water Monitoring Remediation2002，，22： | 1 |
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