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| 1 | H pylori and host interactions that influence pathogenesis显示文摘H pylori is probably the most prevalent human patho- gen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I car- cinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduo- denal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory re- sponse that becomes chronic, along with a detectable adaptive immune response, these responses are ineffec- tive in clearing the infection. H pylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they inter- act with the host epithelium to influence pathogenesis. | Ellen J Beswick Giovanni Suarez Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，35： | 20 |
| 2 | 非运动症状负担、情绪和步态障碍是导致帕金森病非痴呆患者生活质量下降的最重要因素显示文摘帕金森病存在多种运动和非运动症状表现,其中非运动症状对于帕金森病患者生活质量的影响更为严重。改善帕金森病非运动症状,有助于提高患者的生活质量。既往帕金森病非运动症状研究多为单中心小样本研究,所涉及的非运动症状类型较为局限,无法全面反映非运动症状对帕金森病患者生活质量的影响。为此,该研究通过分析COPPADIS-2015研究队列来关注帕金森病患者非运动症状对其生活质量的影响。该队列是西班牙全国范围内为期5年的多中心综合观察性随访队列研究。 | 张煜(编译) Santos Garcia D de Deus Fonticoba T Suarez Castro E | 2020 | 中华医学杂志2020，100，27： | 3 |
| 3 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 4 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 5 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 6 | Novel pharmacological therapy in type 2 diabetes mellitus with established cardiovascular disease: Current evidence显示文摘Cardiovascular diseases(CVDs) remain the leading cause of death in the world and in most developed countries. Patients with type 2 diabetes mellitus(T2DM)suffer from both microvascular and macrovascular diseases and therefore have higher rates of morbidity and mortality compared to those without T2DM. If current trends continue, the Center for Disease Control and Prevention estimates that 1 in 3 Americans will have T2DM by year 2050. As a consequence of the controversy surrounding rosiglitazone and the increasing prevalence of diabetes and CVDs, in 2008 the Food and Drug Administration(FDA) established new expectations for the evaluation of new antidiabetic agents, advising for pre and,in some cases, post-marketing data on major cardiovascular events. As a direct consequence, there has been a paradigm shift in new antidiabetic agents that has given birth to the recently published American Diabetes Association/European Association for the Study of Diabetes consensus statement recommending sodium-glucose cotransporter-2 inhibitors(SGLT2i) and glucagon like peptide-1 receptor agonists(GLP-1RA) in patients with T2DM and established CVD. As a result of over a decade of randomized placebo controlled cardiovascular outcome trials, the aforementioned drugs have received FDA approval for risk reduction of cardiovascular(CV) events in patients with T2DM and established CV disease.SGLT2i have been shown to have a stronger benefit in patients with congestiveheart failure and diabetic kidney disease when compared to their GLP-1RA counterparts. These benefits are not withstanding additional considerations such as cost and the multiple FDA Black Box warnings. This topic is currently an emerging research area and this mini-review paper examines the role of these two novel classes of drugs in patients with T2DM with both confirmed, and at risk for, CVD. | Leonardo Pozo Fatimah Bello Andres Suarez Francisco E Ochoa-Martinez Yamely Mendez Chelsea H Chang Salim Surani | 2019 | World Journal of Diabetes2019，10，5： | 2 |
| 7 | Ni- tric oxide synthase inhibition and food intake effects on motivation to eat and in female mice 显示文摘 | MORLEY J E FARR S A SUAREZ M D | 1995 | Pharma- cology Biochemistry and Behavior1995，50，3： | 1 |
| 8 | Effect of age of feed restriction and microelement supplementa- tion to control ascites on production and carcass charac- teristics of broilers 显示文摘 | Camacho M A Suarez M E Herrera J G | 2004 | Poultry Science2004，，83： | 1 |
| 9 | Catalytic aerobic oxidation of Alco- hols by Fe (NO3) 3-FeBr3 显示文摘 | Martin S E Suarez D E | 2002 | Tetrahedron Lett2002，43，25： | 1 |
| 10 | Selective catalytic hydrodimerization of 1, 3-butadiene by palladium compounds dissolved in ionic liquids 显示文摘 | Dullius J E L Suarez P A Z Einloft S | 1998 | Organometalllcs1998，17，5： | 1 |
| 11 | Ultrasonic endoscope显示文摘 | DiMagno E P Buxton J L Regan P T Hattery R R Wilson D A Suarez J R | 1980 | Lancet1980，1，： | 1 |
| 12 | Competi-tive enzymelinked immunosorbent assay based on a rhoptry-associated protein 1epitope specifically identifies Babesia bo-vis-infected cattle显示文摘 | GOFF W L MCELWAIN T F SUAREZ C E | 2003 | Clin Diagn Lab Immunol2003，10，1： | 1 |
| 13 | Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the timing based on platelet function strategy to reduce clopidogrel- associated bleeding related to CABG (TARGET-CABG) study 显示文摘 | Mahla E Suarez TA Bliden KP | 2012 | Circ Cardiovase Interv2012，5，2： | 1 |
| 14 | The Babesia borismerozoite surface antigen 2 locus contains four tandemly ar- ranged and expressed genes encoding immunologically distinct proteins显示文摘 | FLORIN C M SUAREZ C E HINES S A | 2002 | Infect Immun2002，70，7： | 1 |
| 15 | Plasminogen activator inhibitor-1 :physiological role, regulation, and the influence of common pharmacologic agents 显示文摘 | TSIKOURIS J P SUAREZ J A MEYERROSE G E | 2002 | J Clin Pharmacol2002，42，11： | 1 |
| 16 | Petiveria alliacea: 2 Further flavonoids and triterpenes 显示文摘 | Delle M F Menichini F Suarez L E C | 1996 | Gaz Chim ltal1996，126，5： | 1 |
| 17 | C-reactive protein is associated with psychologcal risk factor of cardiovascular disease in apparently healthy adults 显示文摘 | SUAREZ E C | 2004 | Psychosom Med2004，66，5： | 1 |
| 18 | Application of wavelet trans-forms to damage detection in frame structures显示文摘 | Ovanesova A V Suarez L E | 2004 | Engineer-ing Structures2004，，： | 1 |
| 19 | Corona loss characteristics of contaminated conductors in fair weather显示文摘 | Membello E E Ratta G Suarez H D | 2001 | Electric Power Systems Research2001，59，1： | 1 |
| 20 | The use of new ionic liquids in two-phase catalytic hydrogenation reaction by rhodium complexes显示文摘 | SUAREZ P A Z DULLIUS J E L EINLOFT S | 1996 | Polyhedron1996，15，： | 1 |
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