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| 1 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 2 | miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis显示文摘Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment. | Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 3 | Lung funetion after deep hypothrmic cardiopulmonary bypass in infants显示文摘 | Su Zhaokang Sun Yong Yanmin | 2003 | Asian Cardivasc Thorae Ann2003，11，4： | 1 |
| 4 | Study on Mathematical Model and Lyapunov-Based Control for Three-Level NPC Voltage-Source Rectifier显示文摘 | Meng Yongqing Liu Zheng Su Yanmin ect | 2005 | Proceedings of the IEEE International Symposium on Industrial Electronics p 669-674 vol 22005，2005，： | 1 |
| 5 | Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia显示文摘Background Depressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focusing on the prediction of leptin in diagnosis and evaluation of depressive symptoms in schizophrenia.ObjectiveAims To assess the plasma leptin level in patients with schizophrenia and its relationships with depressive symptoms.Methods Cross-sectional studies were applied to(1) compare the levels of plasma leptin between schizophrenia(n=74) and healthy controls(n=50); and(2)investigate the relationship between plasma leptin levels and depressive subscores.Results(1) Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls.(2) Correlation analysis revealed a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale(PANSS).(3) Stepwise multiple regression analyses identified leptin as an influencing factor for depressed factor score on PANSS.Conclusion Leptin may serve as a predictor for the depressive symptoms of chronic schizophrenia. | Jinjie Xu Yumei Jiao Mengjuan Xing Yezhe Lin Yousong Su Wenhua Ding Cuizhen Zhu Yanmin Peng Dake Qi Donghong Cui | 2018 | General Psychiatry2018，31，6： | 1 |
| 6 | Lung function after deep hypothermic cardiopulmonary bypass in infants 显示文摘 | Su Zhaokang Sun Yong Yang Yanmin | 2003 | Asian Cardlovasc Thorac Ann2003，11，4： | 1 |
| 7 | Optical thermometry based on the upconversion fluorescence from Yb 3+ /Er 3+ codoped La 2 O 2 S phosphor显示文摘 | Yanmin Yang Chao Mi Fang Yu Xianyuan Su Chongfeng Guo Gang Li Jiao Zhang Linlin Liu Yanzhou Liu Xiaodong Li | 2014 | Ceramics International2014，，： | 1 |
| 8 | Better Protection of Pulmonary Surfactant Integrity With Deep Hypothermia and Circulatory Arrest显示文摘 | Yanmin Yang Jiming Cai Shunming Wang Haibo Zhang Jinfen Liu Zhiwei Xu Zhaokang Su | 2006 | The Annals of Thoracic Surgery2006，，1： | 1 |
| 9 | Lung function after deep hypothermic cardiopulmonary bypass in infants显示文摘 | Su Zhaokang Sun Yong Yang Yanmin | 2003 | Asian Cardivasc Thorae Ann2003，11，4： | 1 |
| 10 | Sponta- neous liquid-gas imbibition for characterization of carbon molecular sieves显示文摘 | SU Yanmin XU Shaoping WANG Jifeng | 2012 | Journal of Colloid and Interface Sci ence2012，377，1： | 1 |
| 11 | DSP-based indirect rotor field ori- ented control for 15-phase induction machines 显示文摘 | Hou Lijun Su Yanmin | 2006 | Pro- ceedings of IEEE2006，8，2： | 1 |
| 12 | Lung function after deep hypothermic cardiopulmonary bypass in infants显示文摘 | Sun Yong Yang Yanmin | 2003 | Asian cardiovasc thorac ann2003，11，4： | 1 |
| 13 | Cationic telluroviologen derivatives as type-I photosensitizers for tumor photodynamic theranostics显示文摘The hypoxia of the tumor microenvironment(TME)seriously restricts the photodynamic therapy(PDT)effect of conventional type-II photosensitizers,which are highly dependent on O_(2).In this work,a new type-I photosensitizer(TPE-TeVPPh3)consisting of a tetraphenylethylene group(TPE)as a bioimaging moiety,triphenyl-phosphine(PPh3)as a mitochondria-targeting group,and telluroviologen(TeV2+)as a reactive oxygen species(O_(2)•−,•OH)generating moiety is developed.The luminescence intensity of TPE-TeV-PPh3 increased significantly after specific oxidation by excess H2O2 in the TME without responding to normal tissues via the formation of Te═O bond,which can be used for monitoring abnormal H2O2,positioning,and imaging of tumors.TPE-TeV-PPh3 with highly reactive radicals generation and stronger hypoxia tolerance realizes efficient cancer cell killing under hypoxic conditions,achieving 88%tumor growth inhibition.Therefore,TPE-TeV-PPh3 with low phototoxicity in normal tissue achieves tumor imaging and effective PDT toward solid tumors in response to high concentrations of H_(2)O_(2)in the TME,which provides a new strategy for the development of type-I photosensitizers. | Qi Sun Qi Su Yujing Gao Kun Zhou Weijie Song Penghe Quan Xiaojian Yang Zhishen Ge Yanmin Zhang Gang He | 2023 | Aggregate2023，4，3： | 0 |
| 14 | Syntheses of Lactam Derivatives of Chenodeoxycholic Acid and in vitro Antiproliferative Activity显示文摘 | HUANG Yanmin YAO Qiucui CUI Jianguo GAN Chunfang HUANG Qianyang SU Bing ZHOU Aimin | 2014 | Chemical Research in Chinese Universities2014，30，4： | 0 |
| 15 | Leakage of nuclear material powder from pressure container through a small orifice显示文摘Because of the radioactivity and toxic nature of nuclear materials,their containment within oxide matrices,encased in sealed containers,has been proposed as a suitable means for storage and transportation.However,container failures because of cracks or small orifices present a major leakage risk for nuclear materials,consequently posing a significant hazard to the environment and human beings.In this study,terbium oxide powder was used as a nuclear material representative to examine the leakage of nuclear material powder through orifices located at the base of a pressure container.The dependence of the orifice diameter,the powder layer thickness,and the internal pressure of the container on the leakage mechanism and amount was examined.A simplified model correlating the dependence of the above-mentioned parameters to determine the utmost leakage amount was also developed based on the present results.The leakage of the nuclear material powder was assessed by measuring its concentration using an optical particle counter.The diameter of the orifice determined the powder leakage mechanism,which in turn influenced the amount of leakage produced.Comparison studies showed that unlike the changes in the differential pressure,the volume of the container has little effect on the leakage amount.Under sufficiently high internal pressures,the oxide powder can be released as a fine aerosol.The work is not only crucial from the nuclear safety aspect,but is also beneficial for the safe application of powder and nanoparticles. | Longbo Liu Yanmin Wu Yongyang Su Hanbing Tang Zhihong Zhang Ping Huang Lili Zhang Lixing Zhang | 2014 | Particuology2014，12，3： | 0 |
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