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	题名	作者	年代	出处	被引量
1	Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin显示文摘The aim of this study was to develop a formulation to improve the oral absorption of baicalin(BA)by combining a phospholipid complex(PC)and self-emulsifying microemulsion drug delivery system(SMEDDS),termed BA–PC–SMEDDS.BA–PC was prepared by a solvent evaporation method and evaluated by complexation percentage(CP).The physicochemical properties of BA–PC were determined.The synergistic effect of PC and SMEDDS on permeation of BA was studied in vitro with Caco-2 cells and in situ with a single pass intestinal perfusion model.The improved bioavailability of BA in BA–PC–SMEDDS was confirmed in an in vivo rat model.The CP of BA–PC reached 100%when the molar ratio of drug to phospholipid(PP)was Z1:1.The solubility of BA–PC increased in both water and octanol,and the log P o/w of BA–PC was increased significantly.BA–PC–SMEDDS could be dispersed more evenly in water,compared to BA and BA–PC.Both the Caco-2 cell uptake and single-pass intestinal perfusion models illustrated that transport of BA in BA–PC was lower than that of free BA,while improved significantly in BA–PC–SMEDDS.The relative bioavailability of BA–PC(1:2)–SMEDDS was 220.37%.The combination system of PC and SMEDDS had a synergistic effect on improving the oral absorption of BA.	Huiyi Wu Xiaoying Long Fei Yuan Li Chen Sujing Pan Yunjun Liu Yoshiko Stowell Xiaoling Li	2014	Acta Pharmaceutica Sinica B2014，4，3：	14
2	Full-wave simulation of electromagnetic coupling effects in RF and mixed-signal IC's using a time-domain finite-element method显示文摘	WHITE D A STOWELL M	2004	IEEE Trans MTT2004，52，5：	1
3	Modeling and monitoring of polymorphic transformations during the drying phase of wet granulation显示文摘	DAVIS TD PECK GE STOWELL JG	2004	Pharm Res2004，21，5：	1
4	Progress in the development of RBC substitutes显示文摘	Stowell CP Levin J Spiess BD	2001	Transfusion2001，41，2：	1
5	Xylo-oligosaccharides enhance the growth of bifidobacteria and Bifidobacterium lactis in a simulated colon model显示文摘	H. M?kel?inen S. Forssten M. Saarinen J. Stowell N. Rautonen A. C. Ouwehand	2009	Beneficial Microbes2009，，1：	1
6	Rapid and simple protein-sta- bility screens: application to membrane proteins显示文摘	Yeh AP McMillan A Stowell MH	2006	Aeta Crystallogr D Biol Crystallogr2006，62，4：	1
7	Cavity coalescence in superplastic deformation显示文摘	STOWELL M J LIVESEY D W RIDLEY N	1984	Acta Metallurgica1984，32，：	1
8	Superplastic forming of structural alloys显示文摘	Stowell M J Hamilton N E		TMS0，，：	1
9	Two-dimensional computational fluid dynamics(CFD) modeling of air velocity and ammonia distribution in a High-Rise Hog Building显示文摘	Sun H Stowell R R Keener H M	2002	Transactions of the ASAE2002，45，2：	1
10	Simultaneous open and closed dislocations adjacent metacarpophalangeal joints:a case re- port显示文摘	STOWELL JF RENNIE WP	2002	J Emerg Med2002，23，4：	1
11	Stress and strain concentration at a circular hole inan infinite plate 显示文摘	Stowell E Z	1950	NationalAdvisory Committee for Aeronautics1950，19，9：	1
12	The measurement of strain-rate sensitivity in superplastic alloys显示文摘	J. Hedworth M. J. Stowell	1971	Journal of Materials Science1971，，8：	1
13	Pneumatic Hammer in a Gas Lubricated Externally Pressurized Annular Thrust Bearing显示文摘	STOWELL T B	1971	Journal of Lubrication Technology1971，93，3：	1
14	2-Imino-2-methoxyethyl 1-thioglycosides:new reagents for attaching sugar to proteins显示文摘	Lee YC Stowell C Krantz MJ	1976	Biochemistry1976，15，18：	1
15	Regulation of protein O-glycosylation by the endoplasmie reticulum-localized molceular chaperone Cosmc 显示文摘	Ju T Aryal RP Stowell CJ	2008	J Cell Bioi2008，182，3：	1
16	The Tense of Infinitives显示文摘	Stowell T	1982	Linguistic Inquiry1982，，13：	1
17	Rapid and simple protein-stability screens:application to membrane proteins显示文摘	Andrew P Yeh Andy McMillan Michael H B Stowell	2006	Acta Cryst2006，62，：	1
18	Mechanical properties of Al- 8 wt% Fe-based alloys prepared by rapid quenching from the liquid state显示文摘	THURSFIELD G STOWELL M J	1974	Journal of Material Science1974，9，10：	1
19	2-Imino-2-methoxyethyl 1-thioglycosides: New reagents for attaching sugars to proteins 显示文摘	LEE Y C STOWELL C P KRANTZ M J	1976	Biochemistry1976，15，18：	1
20	Investigations of the electronic properties of doped Ba1-xSrxTiO3 phase shifting materials显示文摘	Sengupta L C Ngo E Stowell S	1994	Ferroelectrics1994，153，：	1

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