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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Improved scoring system for the electrocardiographic diagnosis of left ventricular hypertrophy显示文摘BACKGROUND Left ventricular hypertrophy(LVH) is a common manifestation of cardiovascular disease and a risk factor for cardiovascular morbidity and mortality, but available methods for its electrocardiographic(ECG) diagnosis have limited accuracy.AIM To investigate findings associated with LVH on ECG and developed an improved system for the diagnosis of LVH.METHODS A cohort study comparing ECG data acquired within 30 days of transthoracic echocardiography(TTE) was performed. Multivariate regression analysis identified ECG findings associated with increased LV mass and mass index. A scoring system was derived and performance compared to established criteria for LVH.RESULTS Data from 5486 outpatients with TTEs and corresponding ECGs were included in the derivation cohort, 333(6.1%) of whom had LVH by TTE. In the primary regression analysis, findings associated with LVH were amplitudes of Q in V3, R in V6, S in V3, T in V6, P' in V1, P in V6, as well as R and T-axis discordance, R peak time in V6, QRS duration, weight, height, sex, and age. From this we derived a score consisting of 5 criteria, and validated it in an independent cohort of 910 patients. With a threshold of 1.5 points, sensitivity and specificity were67.9% and 81.4%, and 62.5% and 83.2% in the derivation and validation cohorts,respectively. With a threshold of 2 points, sensitivity and specificity were 42.3% and 93.0%, and 37.5% and 93.4% in these cohorts.CONCLUSIONS This score had superior sensitivity for detection of LVH by ECG while making a modest sacrifice in specificity compared to conventional criteria. | Eric D Braunstein Lori B Croft Jonathan L Halperin Steve L Liao | 2019 | World Journal of Cardiology2019，11，3： | 2 |
| 3 | Analysis of wax hydrocarbons in petroleum source rocks from the Damintun depression, eastern China,using high temperature gas chromatography 显示文摘 | Huang H P Steve R L Gordon D L | 2003 | Organic Geochemistry2003，34，： | 1 |
| 4 | Slezak, An equilibrium model of incentive contracts in the presence of information manipulation显示文摘 | Goldman Eitan and Steve L | 2006 | Journal of Finaneial Economies2006，，80： | 1 |
| 5 | The classical risk model with a constant dividend Barrier: analysis of the Gerber-Shiu penalty function显示文摘 | Sheldon L X Gordon E W Steve D | 2003 | Insurance : Mathematics and Economics2003，33，3： | 1 |
| 6 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 7 | Enterocins in food preservation显示文摘 | HAIDER K STEVE F PAK L Y | 2010 | International Journal of Food Microbiology2010，141，12： | 1 |
| 8 | Food allergen labeling in the USA and Enrope显示文摘 | Taylor Steve L Hefle | | 0，，03： | 1 |
| 9 | Regional geology and geophysics of the eastern Gulf of Guinea (Niger Delta to Rio Muni)显示文摘 | Steve R L Munday S Bray R | 2002 | The Leading Edge2002，10，： | 1 |
| 10 | Microwave Digestion Procedures for Environmental Matrices显示文摘 | Kathryn J L Steve J H | | 0，，07： | 1 |
| 11 | Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice显示文摘 | Ronaldo A Ribeiro Mariana L Vale Sara M Thomazzi Adriana B.P Paschoalato Steve Poole Sergio H Ferreira Fernando Q Cunha | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 12 | Phthalates:toxicogenomics and inferred human diseases显示文摘 | SHER S STEVE S L | 2011 | Genom2011，97，3： | 1 |
| 13 | Characterization of nanocellulose-reinforced shape memory polyurethanes显示文摘 | Auad M L Contos V S Nutt Steve | 2008 | Poly Int2008，57，： | 1 |
| 14 | Reactive evaporation of low-defect density hafnia显示文摘 | Robert C Steve F Gary E L | 1993 | Applied Optics1993，32，28： | 1 |
| 15 | LADAR measurements of the international space station 显示文摘 | Colin L Smithpeter Robert 0 Nellums Steve M Lebien | 2001 | SPIE2001，4377，： | 1 |
| 16 | Youth risk behavior surveillanc - e United States显示文摘 | Laura K Steve K Shari L | 2013 | MMWR2013，63，4： | 1 |
| 17 | Fusarium solani fungal infection of the lateral line canal system in captive scalloped hammerhead sharks (Sphyrna lewini) in Hawaii显示文摘 | Gerald L James A Brock Steve Kaiser | 1995 | Journal of wildlife diseases1995，31，4： | 1 |
| 18 | Optoelectronic microwave oscilla- tor显示文摘 | Steve Yao X Maleki L | 1996 | Journal of Optical Society of America B1996，13，8： | 1 |
| 19 | Seabed properties and sediment erodibility along the western Adriatic margin, Italy显示文摘 | Steves A W Wheatcroft R A Wiberg P L | 2007 | Continental Shelf Research2007，27，34： | 1 |
| 20 | Broadband MIMO-OFDM wireless communications 显示文摘 | Gordon L Sttibcr John R Barry Steve W Mclaughlin | 2004 | Proceedings of the IEEE (S0018-9219)2004，92，2： | 1 |
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